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| 1 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 2 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 3 | Biomarkers in schizophrenia:A focus on blood based diagnostics and theranostics显示文摘Identifying biomarkers that can be used as diagnostics or predictors of treatment response(theranostics) in people with schizophrenia(Sz) will be an important step towards being able to provide personalized treatment. Findings from the studies in brain tissue have not yet been translated into biomarkers that are practical in clinical use because brain biopsies are not acceptable and neuroimaging techniques are expensive and the results are inconclusive. Thus, in recent years, there has been search for blood-based biomarkers for Sz as a valid alternative. Although there are some encouraging preliminary data to support the notion of peripheral biomarkers for Sz, it must be acknowledged that Sz is a complex and heterogeneous disorder which needs to be further dissected into subtype using biological based and clinical markers. The scope of this review is to critically examine published blood-based biomarker of Sz, focusing on possible uses for diagnosis, treatment response, or their relationship with schizophreniaassociated phenotype. We sorted the studies into six categories which include:(1) brain-derived neurotrophic factor;(2) inflammation and immune function;(3) neurochemistry;(4) oxidative stress response and metabolism;(5) epigenetics and micro RNA; and(6) transcriptome and proteome studies. This review also summarized the molecules which have been conclusively reported as potential blood-based biomarkers for Sz in different blood cell types. Finally, we further discusses the pitfall of current blood-based studies and suggest that a prediction model-based, Sz specific, bloodoriented study design as well as standardize blood collection conditions would be useful for Sz biomarker development. | Chi-Yu Lai Elizabeth Scarr Madhara Udawela Ian Everall Wei J Chen Brian Dean | 2016 | World Journal of Psychiatry2016，6，1： | 6 |
| 4 | Effect of focal adhesion kinase on cytoskeletal arrangement of HepG2 cells induced by hypoxia显示文摘对在 hypoxic HepG2 房间和 HepG2 房间的细胞骨架安排上的 FAK siRNA 的效果的焦点的粘附 kinase (FAK ) 表示由组织缺氧导致了的学习客观。方法 HepG2 房间在 21% O 2 和 1% O 2 是有教养的。词法变化在组织缺氧处理以后被观察。西方的污点被用来测量 FAK 表示。指向 FAK 和向量 pGensil-2 的 mRNA 的 siRNA 表示向量 pshRNA-FAK (作为控制) 被构造,然后 transfected 进 HepG2 房间。西方的污点被用来检测 FAK。有组织缺氧导致的 pshRNA-FAK 的 HepG2 房间 transfected 的细胞骨架安排被 phalloidin 分析。有组织缺氧导致的 pshRNA-FAK 的 HepG2 房间 transfected 的迁移的能力被房间迁居试金分析。结果对待组织缺氧的房间与房间分开的大度显示了更多的伸长的形状。FAK 表示在 hypoxic HepG2 房间增加了。FAK 蛋白质水平被 75.64% ±减少 3.12%(P <
0.01 ) 在 pshRNA-FAK transfection 以后。组织缺氧导致了 HepG2 房间的细胞骨架安排。然而,有组织缺氧导致的 pshRNA-FAK 的 HepG2 房间 transfected 的细胞骨架安排在 1% O 2 被禁止。当房间移植试金出现了,有 pshRNA-FAK 的 HepG 房间 transfected 的移居的数字比控制的显著地低(P <
0.05 ) 。在 hypoxic HCC 的 FAK 的表示可能有一种靠近的关系到 HepG2 房间的细胞骨架安排的结论由组织缺氧导致了。FAK 表示的起来规定可以是细胞骨架安排的机制和组织缺氧导致的 hepatocellular 癌的侵略之一。 | Wei Yan Yu Fu Jiazhi Liao Limin Xia Min Luo Qian Zhu Dean Tian | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 4 |
| 5 | Detection of Hypermethylated Vimentin in Urine of Patients with Colorectal Cancer显示文摘 | Benjamin P. Song Surbhi Jain Selena Y. Lin Quan Chen Timothy M. Block Wei Song Dean E. Brenner Ying-Hsiu Su | 2012 | The Journal of Molecular Diagnostics2012，，2： | 2 |
| 6 | Determination of welding deformation in fillet-welded joint by means of numerical simulation and comparison with experimental measurements显示文摘 | Dean Deng Wei Liang Hidekazu Murakawa | 2006 | Journal of Materials Processing Tech2006，，2： | 2 |
| 7 | Recent advances in alkaline hydrogen oxidation reaction显示文摘The development of highly efficient electrocatalysts toward hydrogen oxidation reaction(HOR)under alkaline media is essential for the commercialization of alkaline exchange membrane fuel cells(AEMFCs).However,the HOR kinetics in alkaline is two to three orders of magnitude slower than that in acid.More critically,fundamental understanding of the sluggish kinetics derived from the p H effect is still debatable.In this review,the recent development of understanding HOR mechanism and rational design of advanced HOR electrocatalysts are summarized.First,recent advances in the theories focusing on fundamental understandings of HOR under alkaline electrolyte are comprehensively discussed.Then,from the aspect of intermediates binding energy,optimizing hydrogen binding energy(HBE)and increasing hydroxyl binding energy(OHBE),the strategies for designing efficient alkaline HOR catalysts are summarized.At last,perspectives for the future research on alkaline HOR are pointed out. | Lixin Su Dan Gong Yiming Jin Dean Wu Wei Luo | 2022 | Journal of Energy Chemistry2022，31，3： | 2 |
| 8 | Design and control of an apple harvesting robot 显示文摘 | Zhao Dean Lu Jidong Ji Wei | 2011 | Biosystems Enginee- ring2011，110，2： | 1 |
| 9 | An investigation on the dispersion of montmorillonite(MMT) primary particles in PP matrix显示文摘 | Dean S Wei Yu Robert K | 2007 | European Polymer Journal2007，43，8： | 1 |
| 10 | Determination of welding deformation in fillet-welded joint by means of numerical simulation and comparison with experimental measurements显示文摘 | Dean Deng Wei Liang Hidekazu Murakawa | 2007 | Journal of Materials Processing Technology2007，23，3： | 1 |
| 11 | Numerical simulation of welding distortion in large structures显示文摘 | Dean Deng Hidekazu Murakawa Wei Liang | 2007 | Computer Methods in Applied Mechanics and Engineering2007，，5： | 1 |
| 12 | Measurement of in-herent deformation in typical weld joints using inverse analysis(part 2)显示文摘 | Wei Liang Dean Deng Hidekazu Murakawa | 2005 | Transactions of JWRI2005，34，1： | 1 |
| 13 | Numerical and experimental investigations on welding residual stress in multi-pass butt-welded austenitic stainless steel pipe 显示文摘 | Dean Deng Hidekaze Murakawa Wei Liang | 2007 | Computational materials science2007，42，2： | 1 |
| 14 | Stability of carbon nanotubes under electric field studied by scanning electron microscopy显示文摘 | Wei Y Xie C Dean K A | 2001 | Appl Phys Lett2001，79，： | 1 |
| 15 | Numerical simulation of temperature field and residual stress in multi-pass welds in stainless steel pipe and comparison with experimental measurements 显示文摘 | DENG Dean MURAKAWA Hidekazu LIANG Wei | 2006 | Com- putational Materials Science2006，37，3： | 1 |
| 16 | Design and control of an apple harvesting robot显示文摘 | Zhao Dean Lti Jidong Ji Wei | 2011 | Biosystems Engineering2011，110，2： | 1 |
| 17 | Time-course analyses of abscisic acid level and the expression of genes involved in abscisic acid biosynthesis in the leaves of Betula platyphylla显示文摘 | Rongshu Zhang Chuanping Yang Chao Wang Zhigang Wei Dean Xia Yuefeng Wang Guifeng Liu Yucheng Wang | 2012 | Molecular Biology Reports2012，，3： | 1 |
| 18 | Determination of welding deformation in fillet-welded joint by means of numerical simulation and comparison with experimental measurements显示文摘 | Dean Deng Wei liang Hidekazu M | 2007 | Journnal of Material Processing Technology2007，183，： | 1 |
| 19 | Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies: The RESPOND Study显示文摘 | Paul A. Gurbel Kevin P. Bliden Kathleen Butler Mark J. Antonino Cheryl Wei Renli Teng Lars Rasmussen Robert F. Storey Tonny Nielsen John W. Eikelboom Georges Sabe-Affaki Steen Husted Dean J. Kereiakes David Henderson Dharmendra V. Patel Udaya S. Tantry | 2010 | Circulation2010，，10： | 1 |
| 20 | Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease: The ONSET/OFFSET Study显示文摘 | Paul A. Gurbel Kevin P. Bliden Kathleen Butler Udaya S. Tantry Tania Gesheff Cheryl Wei Renli Teng Mark J. Antonino Shankar B. Patil Arun Karunakaran Dean J. Kereiakes Cordel Parris Drew Purdy Vance Wilson Gary S. Ledley Robert F. Storey | 2009 | Circulation2009，，25： | 1 |
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