|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 2 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 3 | Hurricane disturbances, tree diversity, and succession in North Carolina Piedmont forests, USA显示文摘Windthrow plays a critical role in maintaining species diversity in temperate forests. Do large-scale strong wind events(i.e., tropical cyclones, including hurricanes,typhoons and severe cyclonic storms) increase tree diversity in severely damaged forest areas? Do hurricanes(tropical cyclones that occurs in the Atlantic Ocean and northeastern Pacific Ocean) lead to altered relative abundance of shade-tolerant and shade-intolerant species? Did historic hurricanes alter the succession trajectory of the damaged forests? We used nearly 70-year tree demographic data to assess the effects of two major hurricanes on woody species diversity in Piedmont forests, North Carolina, USA. Species richness(S) and Shannon–Wiener's diversity index(H') were used to evaluate the changes in tree diversity. The changes in composition were assessed with Nonmetric Multidimensional Scaling. The pre-hurricane successional phase can strongly influence both the damage severity and subsequent responses. Although there is often an immediate drop in diversity following a hurricane, understory tree diversity quickly increases to levels that exceed those prior to the disturbance. This leads to an increase in diversity in stands that were substantially damaged. Hurricanes significantly decrease the dominance of shade-intolerant canopy species while increasing preestablished, more shade-tolerant species. We conclude that large, and infrequent hurricanes help to maintain local tree diversity, but also accelerate the increase in dominance of understory species such as red maple and beech. | Weimin Xi Robert K.Peet Michael T.Lee Dean L.Urban | 2019 | Journal of Forestry Research2019，30，1： | 4 |
| 4 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 5 | ABC Transporters, Drug Resistance, and Cancer Stem Cells显示文摘 | Michael Dean | 2009 | Journal of Mammary Gland Biology and Neoplasia2009，，1： | 2 |
| 6 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 7 | Radiofrequency ablation for treatment of medically inoperable stage I non–small cell lung cancer显示文摘 | Michael Lanuti Amita Sharma Subba R. Digumarthy Cameron D. Wright Dean M. Donahue John C. Wain Douglas J. Mathisen Jo-Anne O. Shepard | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，1： | 2 |
| 8 | Fluocinolone Acetonide Intravitreal Implant for Diabetic Macular Edema: A 3-Year Multicenter, Randomized, Controlled Clinical Trial显示文摘 | P. Andrew Pearson Timothy L. Comstock Michael Ip David Callanan Lawrence S. Morse Paul Ashton Brian Levy Eric S. Mann Dean Eliott | 2011 | Ophthalmology2011，，8： | 2 |
| 9 | International evidence-based recommendations for point-of-care lung ultrasound显示文摘 | Giovanni Volpicelli Mahmoud Elbarbary Michael Blaivas Daniel A. Lichtenstein Gebhard Mathis Andrew W. Kirkpatrick Lawrence Melniker Luna Gargani Vicki E. Noble Gabriele Via Anthony Dean James W. Tsung Gino Soldati Roberto Copetti Belaid Bouhemad Angelika | 2012 | Intensive Care Medicine2012，，4： | 2 |
| 10 | Effect of Computerized Tomography on Classification and Treatment Plan for Patellar Fractures显示文摘 | Lionel E. Lazaro David S. Wellman Nadine C. Pardee Michael J. Gardner Jose B. Toro Neil R. MacIntyre David L. Helfet Dean G. Lorich | 2013 | Journal of Orthopaedic Trauma2013，，6： | 2 |
| 11 | Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: Effects on protein- l -isoaspartyl methyltransferase activity显示文摘 | Kusum K. Kharbanda Mark E. Mailliard Cheryl R. Baldwin Michael F. Sorrell Dean J. Tuma | 2007 | Journal of Hepatology2007，，6： | 2 |
| 12 | Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway显示文摘 | Kusum K. Kharbanda Mark E. Mailliard Cheryl R. Baldwin Harriet C. Beckenhauer Michael F. Sorrell Dean J. Tuma | 2006 | Journal of Hepatology2006，，2： | 2 |
| 13 | Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: Protection by betaine显示文摘 | Kusum K. Kharbanda David D. Rogers Mark E. Mailliard Gerri L. Siford Anthony J. Barak Harriet C. Beckenhauer Michael F. Sorrell Dean J. Tuma | 2005 | Biochemical Pharmacology2005，，12： | 2 |
| 14 | New Era of Liver Transplantation for Hepatitis B: A 17-Year Single-Center Experience显示文摘 | Dean M. Anselmo Rafik M. Ghobrial Lee Chan Jung Michael Weaver Carlos Cao Sammy Saab Greg Kunder Pauline W. Chen Douglas G. Farmer Hasan Yersiz Angeles Baquerizo Sunil Geevarghese Steven H. Han Leonard Goldstein Curtis D. Holt Jeffrey A. Gornbein Ronald W | 2002 | Annals of Surgery2002，，5： | 1 |
| 15 | Anderson Photoeatalytic oxidation of acetone vapor on TiO2/ZrO2 thin films显示文摘 | Zorn Michael E Tompkins Dean T Zeltner Walter A | 1999 | Applied Cat ''dysis B: Environmental1999，23，1： | 1 |
| 16 | Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia显示文摘 | Adam M. Deane Nam Q. Nguyen Julie E. Stevens Robert J. L. Fraser Richard H. Holloway Laura K. Besanko Carly Burgstad Karen L. Jones Marianne J. Chapman Chris K. Rayner Michael Horowitz | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，1： | 1 |
| 17 | The Effect of Progressive, Reinforcing Telephone Education and Counseling Versus Brief Educational Intervention on Knowledge, Self-Care Behaviors and Heart Failure Symptoms显示文摘 | David W. Baker Darren A. DeWalt Dean Schillinger Victoria Hawk Bernice Ruo Kirsten Bibbins-Domingo Morris Weinberger Aurelia Macabasco-O’Connell Kathy L. Grady George M. Holmes Brian Erman Kimberly A. Broucksou Michael Pignone | 2011 | Journal of Cardiac Failure2011，，10： | 1 |
| 18 | Indirect Medial Reduction and Strut Support of Proximal Humerus Fractures Using an Endosteal Implant显示文摘 | Michael J Gardner Sreevathsa Boraiah David L Helfet Dean G Lorich | 2008 | Journal of Orthopaedic Trauma2008，，3： | 1 |
| 19 | The Hyperplantarflexion Ankle Fracture Variant显示文摘 | Michael J. Gardner Sreevathsa Boraiah Keith D. Hentel David L. Helfet Dean G. Lorich | 2007 | The Journal of Foot and Ankle Surgery2007，，4： | 1 |
| 20 | Caspases and upstream mechanisms in central nervous system ischemic injury显示文摘 | Michael A Moskowitz Dean A Le Michael J Whalen | 2003 | International Congress Series2003，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员