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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Prospect of preim- plantation genetic diagnosis for heritable mitoehondrial DNA diseases显示文摘 | Dean NL Battersby BJ Ao A | 2003 | Mol Ham Rep2003，9，10： | 1 |
| 3 | Laparoscopic hepaticoduodenostomy versus open hepaticoduodenostomy for reconstruction after resection of choledochal cyst显示文摘 | Santore MT Deans KJ Behar BJ | 2011 | J Laparoendosc Adv Surg Tech A2011，21，4： | 1 |
| 4 | Activities of carbapenem and cornparator agents against contemporary US Pseudomonas aeruginosa isolates from the CAPITAL surveillance program显示文摘 | Morrow BJ Pillar CM Deane J | 2013 | Diagn Microbiol Infect Dis2013，75，4： | 1 |
| 5 | Definition of the ovalbumin gene promoter by transfer of an ovalglobin fusion gene into cultured cells 显示文摘 | Knoll BJ Zarucki-Schulz T Dean D C | 1983 | Nucleic Acids Res1983，11，21： | 1 |
| 6 | 苯、甲苯、二甲苯和酚类的遗传毒理学显示文摘 | Dean BJ 陈自强 | 1980 | 国外医学(卫生学分册)1980，，01： | 1 |
| 7 | Prospect of preimplamadon genetic diagnosis for heritable mitochondrial DNA diseases 显示文摘 | Dean NL Battersby BJ Ao A | 2003 | Mol Hum Reprod2003，9，： | 1 |
| 8 | Activities of carbap- enem and comparator agents against contemporary US Pseudomonas aeruginosa isolates from the CAPITAL surveillance program显示文摘 | Morrow BJ Pillar CM Deane J | 2013 | Diagn Microbiol Infect Dis2013，75，4： | 1 |
| 9 | The management of solita ry tumours of Hoffa/s fat pad显示文摘 | Dean BJ Reed DW Matthews JJ | 2010 | Knee2010，24，3： | 1 |
| 10 | Prospect of preimplantation genetic diagnosis for heritable mitochondrial DNA diseases显示文摘 | Battersby BJ Ao A | 2003 | Mol Hum Reprod2003，9，10： | 1 |
| 11 | Activities of carbapenem and comparator agents against contemporary US Pseudomonas aerug- inosa isolates from the CAPITAL surveillance program 显示文摘 | Morrow BJ Pillar CM Deane J | 2013 | Diagn Microbiol Infect Dis2013，75，： | 1 |
| 12 | Human liver carboxylesterase hCE- 1 : binding specificity for cocaine, heroin and their metabo-lites and analogs显示文摘 | Brzeinski MR Spink BJ Dean RA | 1997 | Drug Metab Dispos1997，25，： | 1 |
| 13 | Activities of earbapenem and comparator agents against contemporary US Pseudomonas aerug- inosa isolates from the CAPITAL surveillance program 显示文摘 | Morrow BJ Pillar CM Deane J | 2013 | Diag Microbiol Infect Dis2013，75，： | 1 |
| 14 | Brain penetration of aprepitant,a substance P receptor antagonist,in ferrets显示文摘 | Huskey SE Dean BJ Bakhtiar R | 2003 | Drug Metab Dis-pos2003，31，6： | 1 |
| 15 | Mesenchymal stem cells:biology and potential clinical uses显示文摘 | Deans BJ Moseley AB | 2000 | Exp Hematol2000，28，8： | 1 |
| 16 | The management of solitarytumours of Hoffa' s fat pad 显示文摘 | Dean BJ Matthews RJ Pandit H | | Knee0，18，2： | 1 |
| 17 | Empiric antibiotic selection and risk prediction of drug-resistant pathogens in community-onset pneumonia显示文摘 | Webb BJ Jones B Dean NC | 2016 | Curr Opin Infect Dis2016，29，2： | 1 |
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