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26篇 您的检索式:作者名="Debbie T"
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1Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown.Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross 2013World Journal of Gastroenterology2013,19,48:8
2Functional polymers from novel carboxyl-terminated trithiocarbonates as highly efficient RAI agents 显示文摘John T L Debby F Rouald S 2002Macromolecules2002,35,:1
3查看详情显示文摘Elaine M T Donald J L J John H.L Debbie A M Peter B F Karen B 0,,:1
4Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A 2014Plant Biotechnol J2014,12,:1
5GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primate 显示文摘Peter T Eric J Debbie T 2010PLoS One2010,5,6:1
6Rapid mobilization decrea- ses length-of-stay in joint replacement patients显示文摘Gregory T Debbie N James S 2013Bulletin of the Hospital for Joint Diseases2013,71,3:1
7Functional polymers from novel carboxyl- terminated trithiocarbonates as highly efficient RAFT agents 显示文摘John T L Debby F Ronald S 2002Macromolecules2002,35,18:1
8Functional polymers from novel carboxyl-terminated trithiocarbonates as highly efficient RAFT agents显示文摘LAO John T FILLA Debby SHEA Ronald 2002Macromolecules2002,35,18:1
9The APN' S guide to pediatric constipation management 显示文摘Debby M Nan T Marlene 1 2004Nurse Pecliatr2004,,:1
10Functional polymers from novelcarboxyl-terminated trithiocarbonates as highly efficient RAFT agents显示文摘John T Lai Debby Filla Ronald Shea 2002Macromolecules2002,35,:1
11Functional polymers from novel carboxyl-terminated trithiocarbonates as highly efficient RAFT agents 显示文摘JOHN T L DEBBY F RONALD S 2002Macromolecules2002,35,18:1
12GM-CSF increases mueosai and systemic immunogenicity of an H1N1 influenza DNA vaccine ad- ministered into the epidermis of non-human primates 显示文摘Peter T Eric J Debbie T 2010PLoS One2010,5,11:1
13Functional polymers from novel carboxyl-terminated trithiocarbonates as highly efficient RAFT agents 显示文摘JOHN T L DEBBY F RONALD S 2002Macromolecules2002,35,18:1
14Cognitive behavioral therapy for sehizophrenia: An overview of treatment显示文摘Debbie M W Aaron T B 2003Cognitive and Behav- ioral Practice2003,10,:1
15Cytotoxic T cell polyepitope vaccines delivered by ISCOMs 显示文摘Thuy T T L Debbie D Jim M 2001Vaccine2001,19,:1
16Functional polymers fromnovel carboxyl-terminated trithiocarbonates as highly efficientRAFT agents显示文摘John T Lai Debby Filla Ronald Shea 2002Macromolecules2002,35,:1
17Codon optimization for high level expression of human bone morphogenetic protein-2 in Escherichia coli 显示文摘Debbie S R Pramesti H T Santika P Y Valerius O Asjarie S S 2012Protein Expression and Purification2012,84,:1
18Is Total Reward Dead? 显示文摘Debbie Lovewell T 2014Employee Benefits2014,,9:1
19Functional polymers from novelcarboxyl-terminated trithiocarbonates as highly efficient RAFT agents 显示文摘John T L Debby F Ronald S 2002Macromolecule2002,35,18:1
20Functional polymers from novelearboxyl-terminated trithiocarbon- ates as highly efficient RAFT agents 显示文摘JOHN T LAI DEBBY FILLA RONALD SHEA 2002Macromolecules2002,35,:1
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