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| 1 | Human papillomavirus does not have a causal role in colorectal carcinogenesis显示文摘AIM: To investigate the presence of human papillomavirus(HPV) DNA along with the integration,the quantification and the expression of the HPV16 in colorectal cancers.METHODS: A prospective series of colorectal tumors were genotyped for HPV DNA.The clinical and pathological variables of the HPV-positive tumors were compared to those of HPV-negative samples.The integration status of HPV16 was evaluated by calculating E2/E6 ng ratios.HPV16-positive tumors were also evaluated for(1) E2,E4,E5,E6 and E7 viral gene ng quantification;(2) relative quantification compared to W12 cells; and(3) viral E2,E4,E5,E6 and E7 mR NA transcripts by real-time polymerase chain reaction.RESULTS: HPV infection was detected in 16.9% of all tumors examined,and HPV16 was the most frequent type detected(63.6% of positive tissues).Notably,the clinical and pathological features of HPV-positive colorectal cancers were not significantly different than those of HPV-negative cancers(χ2 and t-test for all clinical and pathological features of HPV-positive vs HPV-negative colorectal cancers: p ns).HPV16 DNA was present exclusively in episomal form,and the HPV16 E2,E4,E5,E6 and E7 genes were detected in tracenanogram quantities.Furthermore,the HPV16 genes ranged from 10-3 to 10-9 compared to W12 cells at an episomal stage.Although the extractions were validated by housekeeping gene expression,all the HPV16 positive tissues were transcriptionally inactive for the E2,E4,E5,E6 and E7 mR NAs.CONCLUSION: Based on our results,HPV is unlikely involved in colorectal carcinogenesis. | Laura Lorenzon Francesca Mazzetta Emanuela Pilozzi Giordana Uggeri Maria Rosaria Torrisi Mario Ferri Vincenzo Ziparo Deborah French | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 2 | Platelet glycoproteinⅡb/Ⅲareceptors and Glanzmann’s thrombasthenia显示文摘 | Deborah L French Uri Seligsohn | 2000 | Thromb VasculBiol2000，20，3： | 1 |
| 3 | HPV infection and microsatellite instability in squamous lesions of the uterine cervix显示文摘 | Chiara Cermele Andrea Vecchione | 2000 | Anticancer Research2000，20，5： | 1 |
| 4 | Development and application of damage assessment modeling: example assessment for the North Cape oil spill显示文摘 | Deborah French McCay | 2003 | Marine Pollution Bulletin2003，，9： | 1 |
| 5 | Simulation modelling of the effects of oil spills on population dynamics of Northern fur seals显示文摘 | Reed M Deborah P French John Calambokidis | 1989 | Ecological Modelling1989，49，12： | 1 |
| 6 | Overview of a natural resource damage assessment model system for coastal and marine environments显示文摘 | Mark Reed Deborah French Thomas Grigalunas | 1989 | Oil and Chemical Pollution1989，5，： | 1 |
| 7 | Spill hazard evaluation for chemicals shipped in bulk using modeling显示文摘 | DEBORAH P FRENCH MCCAY NICOLE WHITTIER MATTHEW WARD | 2006 | Environmental Modelling & Software2006，21，2： | 1 |
| 8 | Evaluation of the consequences of chemical spills using modeling: chemicals used in deepwater oil and gas operations显示文摘 | DEBORAH P FRENCH MCCAY TATSUSABURO ISAJI | 2004 | Environmental Modelling & Software2004，19，78： | 1 |
| 9 | Development and application of damage assessment modeling:Example assessment for the North Cape oil spill显示文摘 | McCay Deborah French | | 0，，： | 1 |
| 10 | Oil Spill Impact Modeling:Development and Validation显示文摘 | McCay Deborah French | | 0，，10： | 1 |
| 11 | Estimation of potential impacts and natural resource damages of oil 显示文摘 | Deborah French McCay | 2004 | Journal of Hazardous Materials2004，，： | 1 |
| 12 | HPV infection and microsatellite instability in squamous lesions of the uterine cervix显示文摘 | Deborah French Chiara Cermele Andrea Vecchione | 2000 | Anticaneer Research2000，20，： | 1 |
| 13 | Development and Application of an Oil Toxicity and Exposure Model,OILTOXEX显示文摘 | McCay Deborah French | | 0，，10： | 1 |
| 14 | Estimation of potential impacts and natural resource damages of oil显示文摘 | Deborah French McCay Jill Jennings Rowe Nicole Whittier Sankar Sankaranarayanan Dagmar Schmidt Etkin | 2003 | Journal of Hazardous Materials2003，，1： | 1 |
| 15 | Spill hazard evaluation for chemicals shipped in bulk using modeling显示文摘 | DEBORAH P FRENCH MCCAY NICOLE WHITTIER MATFHEW WARD | 2006 | Environmental Modelling & Software2006，21，2： | 1 |
| 16 | Loft的复古装扮 | Deborah French Dana Meijilson Yiorgos Skordakis 肖俊 | 2012 | 现代装饰(家居)2012，0，7： | 0 |
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