|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lack of hepcidin expression attenuates steatosis and causesfibrosis in the liver显示文摘AIM: To investigate the role of key iron-regulatory protein, hepcidin in non-alcoholic fatty liver disease(NAFLD). METHODS: Hepcidin(Hamp1) knockout and floxed control mice were administered a high fat and high sucrose(HFS) or a regular control diet for 3 or 7 mo. Steatosis, triglycerides, fibrosis, protein and gene expression in mice livers were determined by histological and biochemical techniques, western blotting and realtime polymerase chain reaction. RESULTS: Knockout mice exhibited hepatic iron accumulation. Despite similar weight gains, HFS feeding induced hepatomegaly in floxed, but not knockout, mice. The livers of floxed mice exhibited higher levels of steatosis, triglycerides and c-Jun N-terminal kinase(JNK) phosphorylation than knockout mice. In contrast, a significant increase in fibrosis was observed in knockout mice livers within 3 mo of HFS administration. The hepatic gene expression levels of sterol regulatoryelement-binding protein-1c and fat-specific protein-27, but not peroxisome proliferator-activated receptoralpha or microsomal triglyceride transfer protein, were attenuated in HFS-fed knockout mice. Knockout mice fed with regular diet displayed increased carnitine palmitoyltransferase-1a and phosphoenolpyruvate carboxykinase-1 but decreased glucose-6-phosphatase expression in the liver. In summary, attenuated steatosis correlated with decreased expression of lipogenic and lipid storage genes, and JNK phosphorylation. Deletion of Hamp1 alleles per se modulated hepatic expression of beta-oxidation and gluconeogenic genes. CONCLUSION: Lack of hepcidin expression inhibits hepatic lipid accumulation and induces early development of fibrosis following high fat intake. Hepcidin and iron may play a role in the regulation of metabolic pathways in the liver, which has implications for NAFLD pathogenesis. | Sizhao Lu Robert G Bennett Kusum K Kharbanda Duygu Dee Harrison-Findik | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 2 | The use of sulfated polyanions to prevent cell aggregation and enhance recombinant protein production显示文摘 | Dee K U Shuler M L Wood H A Inducing singlecell suspension ofBTI-TN5B1-4insect cells:I | 1997 | Biotechnol Bioeng1997，54，3： | 1 |
| 3 | Slope-dependent friction in a barotropic model显示文摘 | Dees K Nycander J Sigry P | 2004 | J Geophys Res2004，109，01： | 1 |
| 4 | Transmission of PRRS virus from persistently infected sows to contact controls显示文摘 | Bierk M D Dee S A Rossow K D | 2001 | Can J Vet Res2001，65，4： | 1 |
| 5 | The primate ovary contains a population of catecholaminergic neuron-like cells expressing nerve growth factor receptors 显示文摘 | Dees W L Hiney J K Schuhea T D | 1995 | Endocrinology1995，136，： | 1 |
| 6 | Identification of genetically diverse sequences (ORF 5) of porcine reproductive and respiratory syndrome virus in a swine herd显示文摘 | Dee S A Torremorell M Rossow K | 2001 | Can J Vet Res2001，65，4： | 1 |
| 7 | Distinct size of endogeneous siRNAs in maize: Evidence Psequencing in the mopl-lmutant 显示文摘 | Nobuta K distribution from dee Proceedings USA 2008 Lu C Shrivastava R | 2008 | of the National Academy of Sciences of the2008，105，14： | 1 |
| 8 | A fast and elitist multi-objective genetic algorithm:NSGA-Ⅱ显示文摘 | DEE K PRATAP A AGARWAL S | | 0，，02： | 1 |
| 9 | Functional recovery of the developing rat ovary after transplantation:Contribution of the extrinsic innervations显示文摘 | Lara HE Dees WL Green K | 1991 | Endocrinology1991，129，： | 1 |
| 10 | Development of a high-power lithium-ion battery显示文摘 | JANSEN A N KAHAIAN A J KEPLER K D NELSON P A AMINE K DEES D W VISSERS D R THACKERAY M M | 1999 | Journal of Power Sources1999，8182，： | 1 |
| 11 | Activation of canonical Wnt signalling is required for TGF-13-mediatcd fibro- sis显示文摘 | AKHMETSHINA A PALUMBO K DEES C | 2012 | Nat Commun2012，3，： | 1 |
| 12 | Indirect fluorescent IgM anti body response of pigs infected with porcine reproductive and re spiratory syndrome virus显示文摘 | Joo H S Park B K Dee S A | 1997 | Vet Microbiol1997，55，14： | 1 |
| 13 | Functional recovery of the developing rat overy after transplantation: Contribution of the extrinsic iunervation显示文摘 | Lara HE Dees WI Geen K | 1991 | Endocrinology1991，129，： | 1 |
| 14 | Manga- nese induces IGF-1 and cyclooxygenase-2 gene ex- pressionsin the basal hypothalamus during prepubertal- female development 显示文摘 | HINEY J K SRIVASTAVA V K DEES W L | 2011 | Toxicological Science2011，121，2： | 1 |
| 15 | Early life manganese exposure upregulatestumor-associated genes in the hypothalamus of female rats:relationship to manganese-induced precocious puberty 显示文摘 | SRIVASTAVA V K HINEY J K DEES W L | 2013 | Toxico- logical Science2013，136，2： | 1 |
| 16 | Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein显示文摘 | Spencer K A Dee M Britton P | 2008 | Virology2008，370，2： | 1 |
| 17 | Morphogenesis of avian infectious bronchitis virus and a related human virus (strain 229E)显示文摘 | Becker W B Mcintosh K Dees J H | 1967 | J Virol1967，1，： | 1 |
| 18 | Development of a high-power lithium-ion battery显示文摘 | JANSEN A N KAHAIAN A J KEPLER K D NELSON P A AMINE K DEES D W VISSERS D R THACKERAY M M | 1999 | Journal of Power Sources1999，8182，： | 1 |
| 19 | An improvement in hearing sensitivity following hearing-aid fitting in child with an apparent sensorineural hearing impairment显示文摘 | Munro K J Dees D C | 1996 | J Lary Otol1996，110，4： | 1 |
| 20 | Functional recovery of the developing ratovaryafter transplantation:Contributionof the extrinsic innervations显示文摘 | Lara HE Dees WL Green K | 1991 | Endocrinology1991，129，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员