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| 1 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | Differentiation of malignant and benign proximal bile duct strictures: The diagnostic dilemma显示文摘AIM: To identify the criteria for the differentiation of hilar cholangiocarcinoma (HCCA) from benign strictures. METHODS: A total of 68 patients underwent resection of lesions suspicious for HCCA between 1998 and 2006. The results of laboratory investigations, imaging studies and brush cytology were collected. These fi ndings were analyzed to obtain the fi nal diagnosis. RESULTS: Histological examination of the resected specimens confirmed HCCA in 58 patients (85%, group Ⅰ) whereas 10 patients (15%, groupⅡ) were diagnosed to have benign strictures. The most common presenting symptom was obstructive jaundice in 77% patients (79% group Ⅰvs 60% group Ⅱ P = 0.23). Laboratory findings showed greater elevation of transaminase levels in group Ⅰcompared to group Ⅱ The various imaging modalities showed vascular involvement exclusively in the malignant group (36%,P < 0.05). Brush cytology was positive for malignant cells in only 50% patients in group Ⅰ whereas none in group Ⅱ showed malignant cells. CONCLUSION: Despite improvements in imaging techniques, 10 patients (15%) with a presumptive diagnosis of HCCA were ultimately found to have benign strictures. Except for vascular involvement which was associated significantly with malignancy, there were no conclusive features of malignancy on regular imaging modalities. This uncertainty should be taken into account when patients with a suspicious lesion at the liver hilum are considered for resection. | Jaap Jacob Kloek Otto Marinus van Delden Deha Erdogan Fibo Jan ten Kate Erik Anthoni Rauws Olivier Robert Busch Dirk Joan Gouma Thomas Mathijs van Gulik | 2008 | World Journal of Gastroenterology2008，14，32： | 2 |
| 4 | Selective Transcatheter Arterial Embolization for Treatment of Bleeding Complications or Reduction of Tumor Mass of Hepatocellular Adenomas显示文摘 | Deha Erdogan Otto M. Delden Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2007 | CardioVascular and Interventional Radiology2007，，6： | 2 |
| 5 | Performance analysis of an irreversible cascaded heat-transformer 显示文摘 | Goktun S Deha Er I | 2002 | Applied Energy2002，72，2： | 1 |
| 6 | Application of fuzzy extended AHP methodology on shipping registry selection:The case of Turkish maritime industry显示文摘 | Metin Celik Deha Er A.Fahri Ozok | | 0，，01： | 1 |
| 7 | Cerebral Oxygen metabolism inneonatal hypoxic ischemic encephalopathy during and after therapeutichypothermia显示文摘 | Dehaes M Aggarwal A Lin PY | 2014 | J Cereb Blood Flow Metab2014，34，1： | 1 |
| 8 | Nitrogen pollution in the European Union origins and proposed solutions 显示文摘 | VanderVoet E Kleijn R DeHaes H A U | 1996 | Environment Conservation1996，23，2： | 1 |
| 9 | Optimum performance of irreversible cascaded and double effect absorption refrigerators显示文摘 | Selahattin GoEktun Deha Er | 2000 | Applied Energy2000，67，3： | 1 |
| 10 | Biological treatment of acid dyeing wastewater using a sequential anaerobic/ aerobic reactor system显示文摘 | Isik Mustafa Sponza Deha Teresa | 2006 | Enzyme and Microbial Tech- nology2006，38，7： | 1 |
| 11 | Structuring Fuzzy Integrated Multi-stages Evaluation Model on Academicpersonnel Recruitment in MET Institutions显示文摘 | Metin Celika Ahmet Kandakoglu I Deha Er | 2009 | Expert Systems with Appli- cations2009，，36： | 1 |
| 12 | Ecological compensation in dutch highway planning 显示文摘 | Cuperus R Bakermans M M Dehaes H A | 2001 | Journal of Environmental Management2001，27，1： | 1 |
| 13 | Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia 显示文摘 | Dehaes M Aggal~'al A Lin PY el al | 2014 | J Cereb Blood Flow Metab2014，34，1： | 1 |
| 14 | Ecological Compensation in Dutch Highway Planning显示文摘 | Cuperus R Bakermans M M Dehaes H A | 2001 | Journal of Environmental Management2001，27，1： | 1 |
| 15 | Compensation of thermal deformations in machine tools with neural nets显示文摘 | P. Vanherck J. Dehaes M. Nuttin | 1997 | Computers in Industry1997，，1： | 1 |
| 16 | SWOT analysis for safer carriage of bulk liquid chemicals in tankers显示文摘 | OZCAN ARSLAN ISMAIL DEHA ER | 2008 | Journal of Hazardous Materials2008，，154： | 1 |
| 17 | Bin d ing an dgermination of Aspergillus fumigatus conidia on cultured A549pneumocytes显示文摘 | DeHa r t DJ Agwu DE Ju l i an NC e t a l | 1997 | J Infect Dis1997，175，1： | 1 |
| 18 | Eicosapentaenoic acid,a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha,IL-6 and PGE2 expression in UVB-irradiated human keratinocytes显示文摘 | Pupe A Moison R DeHaes P | 2002 | J Invest Dermatol2002，118，： | 1 |
| 19 | Ship security system requirements for ship management companies 显示文摘 | DEHA E I | 2004 | Brodogradnja2004，52，2： | 1 |
| 20 | Cerebral oxygen metabolismin neonatal hypoxic ischemic encephalopathy during and after therapeutichypothermia显示文摘 | Dehaes M Aggarwal A Lin PY | 2014 | J Cereb Blood FlowMetab2014，34，1： | 1 |
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