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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | From engineering design research to engineering pedagogy : Bringing research results directly to the students 显示文摘 | Borgford - Parnell J Deibel K Atman C J | 2010 | International Journal of Engineering Education2010，26，4： | 1 |
| 3 | Seasonal and development variation in the fatty acid composition of Mysis mixta (Mysidacea) and Acanthostepheia malmgreni(Amphipoda) from the hyperbenthos of a cold-ocean environment (Conception Bay,Newfoundland)显示文摘 | Richoux N B Deibel D Thompson R J | | 0，，： | 1 |
| 4 | Destruction of chloropigments in copepod guts显示文摘 | Bochdansky A B Deibel D | 1997 | Mar Ecol Prog Ser1997，147，： | 1 |
| 5 | Crystal structure of type Ⅱ peptide deformylase from Staphylococcus aureus显示文摘 | Baldwin ET Harris MS Deibel MR | 2002 | J Biol Chemi2002，277，34： | 1 |
| 6 | Synthesis of the SedNet Work Package 4 Outcomes显示文摘 | Bortone G Arevalo E Deibel I | 2004 | Sediment and Dredged Material Treatment2004，4，4： | 1 |
| 7 | Photoconductive Terahertz antenna with radial symmetry显示文摘 | Deibel J A Escarra M D Mittleman D M | 2005 | Quantum Electronics and Laser Science2005，41，5： | 1 |
| 8 | Intracoronary eptifibatide bolus administration during percutaneous coronary re- vascularization for acute coronary syndromes with evaluation of platelet glycoprotein Ⅱb/Ⅲa receptor occupancy and platelet function :the intracoronary eptifibatide (ICE) trial 显示文摘 | DEIBELE AJ JENNINGS KL TCHENG JE | 2010 | Circula- tion2010，121，6： | 1 |
| 9 | Physiological and tran- scriptional response of Lactobacillus casei ATCC 334 to acid stress 显示文摘 | Broadbent J R Larsen R L Deibel V | 2011 | Journal of Bacteriology2011，192，9： | 1 |
| 10 | Attenuation compensation in distributed amplifier design显示文摘 | S Deibele J B Beyer | 1989 | IEEE Trans Microwave Theory Tech1989，37，9： | 1 |
| 11 | EspE,a novel secreted protein of attaching and effacing bacteria,is directly translocated into infected host cells,where it appears as a tyrosine-phosphorylated 90 KDa protein显示文摘 | Deibel C Krmer S Chakeaborty T | 1998 | Mol Microbiol1998，28，3： | 1 |
| 12 | Organic solar cell efficiencies under the aspect of reduced surface recombination velocities显示文摘 | WAGENPFAHL A DEIBEL C DYAKONOV V | 2010 | IEEE Journal of Selected Topics in Quantum Electronics2010，16，6： | 1 |
| 13 | Intracoronary eptifi-batide bolus administration during percutaneous coronary revascu-larization for acute coronary syndromes with evaluation of plateletglycoprotein IIb/IIIa receptor occupancy and platelet function:theIntracoronary Eptifibatide(ICE)Trial显示文摘 | Deibele A J Jennings L K Tcheng J E | 2010 | Circulation2010，121，6： | 1 |
| 14 | Intracoronary eptifi- batide bolus administration during percutaneous coronary revascu- larization for acute coronary syndromes with evaluation of platelet glycoprotein Ⅱ b /Ⅲ a receptor occupancy and platelet function The Intracorona/y Eptifibatide ( ICE ) Trim 显示文摘 | Deibele A J Jennings LK Tcheng JE | 2010 | Circulation2010，121，6： | 1 |
| 15 | Investigation of electronic trap states in organic photovoltaic materials by current-based deep level transient spectroscopy显示文摘 | NEUGEBAUER S RAUH J DEIBEL C | 2012 | Applied Physics Letters2012，100，26： | 1 |
| 16 | Consequences of model specification for the determination of gut evacuation rates: redefining the linear model显示文摘 | Bochdansky A B Deibel D | 2001 | Can J Fish Aquat Sci2001，58，5： | 1 |
| 17 | Polymer-fullerene bulkheterojunction solar cells 显示文摘 | Deibel C Dyakonov V | 2010 | Rep Prog Phys2010，73，： | 1 |
| 18 | Intracoronary bolus administration of eptifibatide during percutaneous coronary stenting for non ST elevation myocardial infarction and unstable angina显示文摘 | Deibele AJ Kirtane AJ Pinto DS | 2006 | J Thromb Thrombolysis2006，22，1： | 1 |
| 19 | Attenuation compensation in distributed amplifier design显示文摘 | Deibele S Beyer J B | 1989 | IEEE Trans Microwave Theory Tech1989，37，9： | 1 |
| 20 | Fluoroscopic study of tumor motion due to breathing: Facilitating precise radiationtherapy for lung cancer patients 显示文摘 | Chen Q S Weinhous M S Deibel F C | 2001 | Medical Physics2001，28，9： | 1 |
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