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| 1 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 2 | 汽车电子技术的发展趋势显示文摘电子技术在汽车工业中占有非常重要的地位。它可满足现代化车辆在燃油经济性 ,排放 ,安全性 ,舒适性和动态驾驶等方面的要求。但是对车辆制造商而言 ,在诸如 42 V车载电源 ,独立系统和多媒体技术的集成及软件的开发和使用等方面具有很大的挑战。同时为适应“新经济”的步伐 ,“经典的汽车工业”必须熟悉其游戏规则以及面对来自计算机和通讯工业新的竞争。 | Wolfgang Runge Harald Deiss Josef Schwarz Hubert Remmlinger | 2003 | 传动技术2003，17，2： | 2 |
| 3 | Retroinfusion of NF-кB decoy oligonueleotide extends eardioproteetion achieved by CD18 inhibition in a preelinical study of myocardial ischemia and retroinfusianin pigs 显示文摘 | Kupatt C Wichels R Deiss M | 2002 | Gene Ther2002，9，2： | 1 |
| 4 | Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Rafl to G protein-coupled receptor kinase (GRK) 2 显示文摘 | Deiss K Kisker C Lohse M J | 2012 | J Biol Chem2012，287，23： | 1 |
| 5 | Average voltage, energy density, and specific energy of lithium-ion batteries: calculation based on first principles 显示文摘 | Deiss E Wokaun A Barras J L | 1997 | J Electrochem Soc1997，144，11： | 1 |
| 6 | Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf-1 to G protein-coupled receptor kinase (GRK) 2显示文摘 | Deiss K Kisker C Lohse MJ | 2012 | J Biol Chem2012，287，23： | 1 |
| 7 | Identification of Anovel Serine/threonine Kinase and a Novel 15-kD Protein as Potential Mediators of the γinterferoninduced Cell Death显示文摘 | Deiss L P Feinstein E Berissa H | 1995 | Genes Devel1995，9，： | 1 |
| 8 | Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the γ interferon-induced dell death显示文摘 | Deiss L P Feinstein E Berissi H | 1995 | Genes Dev1995，9，： | 1 |
| 9 | An identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death显示文摘 | Deiss LP Feinstein E Berissi H | 1995 | Genes Dev1995，9，1： | 1 |
| 10 | Spurious chemical diffusion coefficients of Li^+ in electrode materials evaluated with GITT 显示文摘 | DEISS E | 2005 | Electrochimica Acta2005，50，14： | 1 |
| 11 | Natural course of autoimmune thyroiditis in type 1 diabetes, association with gender, age, diabetes duration, and puberty显示文摘 | Kordonouri O Hartmann R Deiss D | 2005 | Arch Dis Child2005，90，4： | 1 |
| 12 | Seroprevalence and Seroincidence of Herpes Simplex Virus(2006-2010),Syphilis(2006-2010),and Vaccine-Preventable Human Papillomavirus Subtypes(2000-2010) Among US Military Personnel显示文摘 | Masel J Deiss RG Wang X | 2015 | Sex Transm Dis2015，42，5： | 1 |
| 13 | Modeling of the chargedischarge dynamics of lithium manganese oxide electrodes for lithium-ion batteries显示文摘 | HARINGER D NOVAK P | 2001 | Electrochimica Acta2001，46，2627： | 1 |
| 14 | Epitaxial growth of GaN thin films on sapphire ( 0001 ) by pulsed laser deposition : influence of surface prepara- tion and nitridation 显示文摘 | DEISS J L HIRLIMANN C H LOISON J L | 2001 | Materials Science and Engneering: B2001，82，12： | 1 |
| 15 | Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes, duration and puberty显示文摘 | Kordonouri O Hartmann R Deiss D | 2005 | Arch Dis Child2005，90，： | 1 |
| 16 | Successful treatment with liraglutide in type 1 diabetes and MODY显示文摘 | Deiss D Diederich S Kordonouri O | | 0，，： | 1 |
| 17 | Improved glycemic control in poorly controlled patients with type 1 diabetes using real-time continuous glucose monitoring显示文摘 | Deiss D Bolinder J Rivelinc JP | 2006 | Diabetes Care2006，29，12： | 1 |
| 18 | Retroinfusion of NFkappaB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs显示文摘 | Kupatt C Wichels R Deiss M Molnar A | 2002 | Gene Ther2002，9，8： | 1 |
| 19 | Maternalandperinataloutcomesduringexpectantmanagementof239sevelpre-eclampticwomenbetween24and33weeks gestation显示文摘 | HaddadB DeisS GoffinetF eta1 | 2004 | AmJObstetGynecol2004，190，6： | 1 |
| 20 | Raf kinase inhibitor protein ( RKIP) dimer formation controls its target switch from Rafl to G protein -coupled receptor kinase (GRK) 2 显示文摘 | Deiss K Kisker C Lohse MJ | 2012 | J Bioi Chern2012，287，23： | 1 |
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