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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Hypolipidemic and antioxidant effects of hydroxycinnamic acids,quercetin,and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study)显示文摘 | DUCHNOWICZ P BRONCEL M PODS?DEK A | 2012 | European Journal of Nutrition2012，51，4： | 1 |
| 3 | A Markov chain model for subsurface characterization: Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001，33，5： | 1 |
| 4 | Insight into the cir-cadian clock within rat colonic epithelial cells显示文摘 | Sládek M Rybová M Jindráková Z | | 0，，04： | 1 |
| 5 | On the behaviour of the penetration twin abundance on {100{ diamond facets显示文摘 | Knuyt G Nesla'dek M Quaeyhaegens C | 1998 | Diamond and Related Materials1998，7，8： | 1 |
| 6 | A Markov Chain Model for subsurface characterization theory and applications 显示文摘 | Elfeki A Dekking M | | Mathematical Geology0，33，5： | 1 |
| 7 | Matrix effects on the stability and antioxidant activity of red cabbage anthocyanins under simulated gastrointestinal digestion显示文摘 | Podsdek A Redzynia M Klewicka E | 2014 | Bio Med Research International2014，，： | 1 |
| 8 | Executive functions processed in the frontal and lateral temporal cortices:intracerebral study显示文摘 | Bocková M Chládek J Jurák P | 2007 | Clin Neurophysiol2007，118，： | 1 |
| 9 | A Markov chain model for subsurface characterization :Theory and applications 显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001，33，5： | 1 |
| 10 | Effect of 1,25-dihydroxy vitaminD 3 on induction of chondrocyte maturation in culture:extracellular matrix gene expression and morphology显示文摘 | Gerstenfeld LC Kelly CM Dek M | 1990 | Endocrinology1990，126，： | 1 |
| 11 | A Markov chain model for subsurface characterization: theory and application显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001，33，5： | 1 |
| 12 | Femoroacetabular impingement syndrome-efficacy of surgical treatment with regards to age and basic diagnosis显示文摘 | Chládek P Musálek M Tr T | 2015 | Int Orthop2015，39，3： | 1 |
| 13 | Whether to target single or multiple CDKs for therapy That is the question显示文摘 | W?sierska-G?dek J Maurer M Zulehner N | | 0，，02： | 1 |
| 14 | A Markov Chain model for subsur- face characterization: Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathe- matical Geology2001，33，5： | 1 |
| 15 | A Markov chain model for subsurface characterization:Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001，33，5： | 1 |
| 16 | A Markov chain model for subsurface char- acterization: theory and applications 显示文摘 | Elfeki A Dekking M | 2001 | Math Geol2001，33，5： | 1 |
| 17 | Promotion of apoptosis in cancer cells by selective purine derived pharmacological CDK inhibitors: one outcome, many mechanisms 显示文摘 | W sierska-G dek J Maurer M | 2011 | Curr Pharm Des2011，17，3： | 1 |
| 18 | Photosystem II-based bio-sensors for the detection of pollutants显示文摘 | GIARDI M T KOBLíZEK M MASOJíDEK J | 2001 | Biosens Bioeletron2001，16，912： | 1 |
| 19 | Promotion of apoptosis in cancer ceils by selective purine-derived pharmacological CDK inhibitors: one outcome, many mechanisms显示文摘 | W? sierska G? dek J Maurer M | 2011 | Curr Pharm Des2011，17，3： | 1 |
| 20 | On the behaviour of the penetration twin abundance on { 100 } diamond facets显示文摘 | Knuyt G Nesla'dek M Quaeyhaegens C Stals L M | 1998 | Diamond and Related Materials1998，7，： | 1 |
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