|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?显示文摘Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality,and are disproportionately affected by cardiovascular disease.Most of this excess risk is it associated with an augmented prevalence of well-known risk factors such as hypertension,dyslipidaemia and obesity in these patients.However the improved cardiovascular disease in type 2 diabetes mellitus patients can not be attributed solely to the higher prevalence of traditional risk factors.Therefore other non-traditional risk factors may be important in people with type 2 diabetes mellitus.Cardiovascular disease is increased in type 2 diabetes mellitus subjects due to a complex combination of various traditional and non-traditional risk factors that have an important role to play in the beginning and the evolution of atherosclerosis over its long natural history from endothelial function to clinical events.Many of these risk factors could be common history for both di-abetes mellitus and cardiovascular disease,reinforcing the postulate that both disorders come independently from'common soil'.The objective of this review is to highlight the weight of traditional and non-traditional risk factors for cardiovascular disease in the setting of type 2 diabetes mellitus and discuss their position in the pathogenesis of the excess cardiovascular disease mortality and morbidity in these patients. | Iciar Martín-Timón Cristina Sevillano-Collantes Amparo Segura-Galindo Francisco Javier del Caizo-Gómez | 2014 | World Journal of Diabetes2014，5，4： | 32 |
| 2 | Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics显示文摘Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented. | Antonio Garcia-Gomez Fermin Sanchez-Guijo M Consuelo del Caizo Jesus F San Miguel Mercedes Garayoa | 2014 | World Journal of Stem Cells2014，6，3： | 5 |
| 3 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 4 | Short-term effects of temperature and COD in a microbial fuel cell显示文摘 | A. Gonzalez del Campo J. Lobato P. Ca?izares M.A. Rodrigo F.J. Fernandez Morales | 2013 | Applied Energy2013，，： | 1 |
| 5 | Stabilization of all-trans-lycopene from tomato by encapsulationusing cyclodextrins显示文摘 | Gracia Patricia Blanch a Mar?' a Luisa Ruiz del Castillo a Mar?' a del Mar Ca | 2007 | Food Chemistry2007，，105： | 1 |
| 6 | Persistent sodium current, membrane properties and bursting behavior of pre-botzinger complex inspiratory neurons in vitro显示文摘 | Del Negro CA Koshiya N Butera ILl | 2002 | Journal of Neurophysiology2002，88，5： | 1 |
| 7 | Transcatheter aortic valve implantation显示文摘 | Del Valle-Fernández R Martinez CA Ruiz CE | 2010 | Cardiol Clin2010，28，1： | 1 |
| 8 | Characterization oF HLA class I altered phenotypes in a panel o{ human mela- noma cell lines显示文摘 | Mendez R Rodriguez T Del CA | 2008 | Cancer Immunol Immunother2008，57，5： | 1 |
| 9 | The viable but nonculturable state and starvation are different stress responses of Enterococcusfaecalis as determined by proteome analysis 显示文摘 | Heim S Maria Del Mar Lleo Barbara Bonato Guzman CA Canepari P | 2002 | Bacteriology2002，184，23： | 1 |
| 10 | Antioxidant defences under hyperoxygenic and hyperosmotic conditions in leaves of two lines of maize with differential sensitivity to drought显示文摘 | Del Logo OT Gonzalez CA Pastori GM | 1993 | Plant cell Physiol1993，34，： | 1 |
| 11 | Role of endothelin in the pathogenesis of hypertension显示文摘 | Perez del Villar C Garcia Alonso CJ Feldstein CA | 2005 | Mayo Clin Proc2005，80，1： | 1 |
| 12 | Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: Involvement of perisinusoidal stellate cells显示文摘AIM: To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis.METHODS: Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S, respectively), we analyzed the liver's capability of recovery after the treatment with a normal-lipidic diet (5% fat as olive oil or sunflower oil, NL-O and NL-S, respectively) by immunocytochemical and Western blot analysis of glial fibrillary acidic protein (GFAP) expression in PSCs, collagen quantification and serum aminotransferase determination.RESULTS: The fatty infiltration in the steatotic livers decreased after the treatment with both NL diets, indicating liver recovery. This decrease was accompanied with a lower collagen deposition and aminotransferase level as well as changes in the PSC population that increased the GFAP expression. The above-mentioned effects were more pronounced in animals fed on NL-O based diet. CONCLUSION: Treatment with a balanced dietenriched in olive oil contributes to the liver recovery from a stea totic process. The PSC phenotype is a marker of this hepatic-recovery model. | Raquel Hernández Esther Martínez-Lara Ana Cauelo Ma Luisa del Moral Santos Blanco Eva Siles Ana Jiménez Juan ngel Pedrosa Ma ngeles Peinado | 2005 | World Journal of Gastroenterology2005，11，47： | 1 |
| 13 | 纳多洛尔治疗婴幼儿血管瘤显示文摘该文作者报道了采用口服纳多洛尔代替普萘洛尔治疗3例婴幼儿血管瘤的经验。婴幼儿血管瘤是一种先天性良性血管性肿瘤,新生儿发病率可高达10%,未能完全消退的血管瘤常常遗留局部色素沉着、瘢痕、畸形,位于关键部位的血管瘤还能引起更为严重的并发症,甚至危及生命。 | Villalba-Moreno AM Cotrina-Luque J Del Vayo-Benito CA | 2015 | 中国口腔颌面外科杂志2015，13，1： | 1 |
| 14 | Methodological evaluation to analyze functional recovery after sciatic nerve injury显示文摘 | Schiaveto de Souza A da Silva CA Del Bel EA | 2004 | J Neurotrauma2004，21，5： | 1 |
| 15 | Identification of amino acid residues in the Ah receptor involved in ligand binding 显示文摘 | Goryo K Suzuki A Del Carpio CA | 2007 | Biochem Biophys Res Commun2007，354，： | 1 |
| 16 | Laparoscopic cholecystectomy : relationship of pathology and operative time 显示文摘 | Del Pin CA Arthur KS Honiq C | 2002 | JSLS2002，6，2： | 1 |
| 17 | Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice 显示文摘 | Rao G Pedone CA Del Valle L | 2004 | Oncogene2004，23，36： | 1 |
| 18 | Carboxy-terminal telopeptide ( CTX ) and amino-terminal propeptide ( PINP ) of type I collagen as markers of bone metastases in patients with non-small cell lung cancer 显示文摘 | Lumachi F Santeufemia DA Del CA | 2013 | Anticancer Res2013，33，6： | 1 |
| 19 | In vitro growth in acute myeloblastic leukemia:clinico-biological correlations显示文摘 | del Ca(n)izo C Galende J Almeida J | 1999 | Leuk Lymphoma1999，36，12： | 1 |
| 20 | Short-term effects of temperature and COD in a microbial fuel cell显示文摘 | GONZALEZ DEL CAMPO A LOBATO J CAIZARESB P RODRIGO M A FERNANDEZ MORALESA F J | 2013 | Appl Energy2013，101，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员