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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis. | Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar | 2008 | World Journal of Gastroenterology2008，14，17： | 11 |
| 3 | Effects of propafenone on calcium current in guinea -pig ventricular myocytes显示文摘 | Delgado C Tamau-go J Henzel D | 1993 | Br J Pharmacol1993，108，3： | 1 |
| 4 | Anti inflammatory neuropeptides: a new class of endogenous immunoregulatory agents显示文摘 | Delgado M Ganea D | 2008 | Brain Behav Immun2008，22，8： | 1 |
| 5 | Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit expression of Fas ligand in activated T lymphocytes by regulating c-Myc,NF-kappa B,NF-AT,and early growth factors 2/3显示文摘 | Delgado M Ganea D | 2001 | J Immunol2001，166，2： | 1 |
| 6 | Immunobiology of vasoactive intestinal peptide (VIP) 显示文摘 | Pozo D Delgado M Martinez M | 2000 | Immunol Today2000，21，1： | 1 |
| 7 | PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimization of coupling techniques 显示文摘 | Francis C E Fisher D Delgado C | 1998 | Int J Hematol1998，68，3： | 1 |
| 8 | Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) as modulators of both the innate and adaptive immunity显示文摘 | Ganea D Delgado M | 2002 | Crit Rev Oral Biol Med2002，13，3： | 1 |
| 9 | U- niportal video-assisted thoracoscopic lobeaolny 显示文摘 | GONZALEZ-RIVAS D FIEIRA E DELGADO M | 2013 | J Thoracic Dis2013，5，3： | 1 |
| 10 | Vasoactive intestinal polypeptide induces regulatory dendritic cells that pre vent acute graft versus host disease and leukemia relapse after bone marrow transplantation显示文摘 | Delgado M Chorny A Ganea D | 2006 | Ann N Y Acad Sci2006，1070，： | 1 |
| 11 | Bacteriocin production by Lactobacillus pentosus B96 can be expressed as a function of temperature and NaC1 concentration显示文摘 | DELGADO A BRITO D PERES C | 2005 | Food Microbiology2005，22，6： | 1 |
| 12 | Emergence of imipenem resistance in clinical Escherichia coli during therapy显示文摘 | Oteo J Delgado·lribarren A Vega D | 2008 | Int J Antimicrob Agents2008，32，6： | 1 |
| 13 | VIP and PACAP inhibit activation induced apoptosis in T lymphocytes显示文摘 | Delgado M Ganea D | 2000 | Ann N Y Acad Sci2000，921，1： | 1 |
| 14 | Double sleeve uniportal video-assisted thoracoscopic lobectomy for non-small cell lung cancer 显示文摘 | GONZALEZ'-RIVAS D DELGADO M FIEIRA E | 2014 | Ann Car- diothorac Surg2014，3，2： | 1 |
| 15 | Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance显示文摘 | Rocío García Garza Pablo Sarobe Juana Merino Juan J. Lasarte Delia D’Avola Virginia Belsue José A. Delgado Leyre Silva Mercedes I?arrairaegui Bruno Sangro Jesus J. Sola Fernando Pardo Jorge Quiroga J. Ignacio Herrero | 2013 | Liver Transpl2013，，9： | 1 |
| 16 | Long term 15N studies in a catena of the shortgrass steppe显示文摘 | Delgado J A Mosier A R Valentine D W Schimel D S Parton W J | 1996 | Biogeochemistry1996，32，： | 1 |
| 17 | Cognitive deficiency in mild hypothyroidism显示文摘 | Quijano T D S Delgado C Espinosa S M | 2000 | Neurologia2000，15，5： | 1 |
| 18 | Influence of body mass index on outcome of pediatric chronic hepatitis Cvirus infection显示文摘 | Delgado -Borrego A Healey D Negre B | 2010 | J Pediatr Gastroenterol Nutr2010，51，2： | 1 |
| 19 | Understanding the mechanism of protamine in solid lipidnanoparticle-based lipofection: the importance of the entrypathway显示文摘 | Delgado D del Pozo-Rodríguez A Solinís Má | 2011 | Eur J Pharm Biopharm2011，79，3： | 1 |
| 20 | Vasoactive intestinal peptide: the dendritic cell --> regulatory T cell axis显示文摘 | Delgado M Gonzalez-Rey E Ganea D | 2006 | Ann N Y Acad Sci2006，1070，： | 1 |
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