|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Decline in intra- cellular free MgZ+is associated with irreversible tissue in- jury after brain trauma 显示文摘 | Vink R Mcintosh T K Demediuk | 1988 | Journal of Biological Chemis- try1988，263，2： | 1 |
| 3 | The role of excitatory amino acids and NMDA receptors in traumatic brain injury 显示文摘 | Faden AI Demediuk P Panter SS Vink R | 1989 | Science1989，244，4906： | 1 |
| 4 | Lipid hydrolysis and peroxidation in injured spinal cord:partial protection with methylprednisolone or vitamin E and selenium显示文摘 | Anderson DK Saunders RD Demediuk P | 1985 | Cent Nerv Syst Trauma1985，2，4： | 1 |
| 5 | The role of excitatory amino acids and NMDA recept'ors in traumatic head injury显示文摘 | Faden AI Demediuk P Panter SS | 1989 | Science1989，244，： | 1 |
| 6 | Decline in intracellular free Mg^2+ is associated with irreversidle tissue injury after brain trauma 显示文摘 | Vink R Mclntosh TK Demediuk P | 2008 | JBiolChem2008，263，： | 1 |
| 7 | Traumatic spinal cord injury in rabbits decreases intracellular free magnesium concentration as measured by 31p MRS显示文摘 | Vink R Yum SW Demediuk P | | 0，，01： | 1 |
| 8 | Effects of methl-prednisolone and the combination of alpha-tocopherol and se-lenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue显示文摘 | Saunders RD Dugan LL Demediuk P | 1987 | J Neurochem1987，49，1： | 1 |
| 9 | Decline in intracellular fee Mg^2+ is associated with irreversible tissue injury after brain traum显示文摘 | Vink R McIntosh TK Demediuk P | 1988 | Bid Chem1988，263，2： | 1 |
| 10 | Decline in intracellular free Mg^2+ is associated with irreversible tissue injury after brain trauma 显示文摘 | Vink R McIntosh TK Demediuk P | 1988 | J Biol Chem1988，263，： | 1 |
| 11 | The role of ecitatory amino acids and NMDA receotors in traumatic head injury显示文摘 | Demediuk P Panter SS | 1989 | Science1989，244，： | 1 |
| 12 | Effects of methylprednisolone and the combination of alpha-gocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue显示文摘 | Sauaders RD Dugan LL Demediuk P | 1987 | J Neurochem1987，49，： | 1 |
| 13 | Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue 显示文摘 | Saunders RD Dugan LL Demediuk P | 1987 | J Neurochem1987，49，1： | 1 |
| 14 | Study of magnesium oxy-sul- phates 显示文摘 | Demediuk T Cole W F A | 1957 | Australian J Chem1957，10，2： | 1 |
| 15 | Lipid hydrolysis and peroxidation in injured spinal cord:partial protection with methylprednisolone or vitamin E and slenium 显示文摘 | Anderson DK Saunders RD Demediuk P | 1985 | Cent Nerv Syst Trauma1985，2，4： | 1 |
| 16 | A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter显示文摘 | Merchant JL Demediuk B Brand SJ | 1991 | Mol Cell Biol1991，11，： | 1 |
| 17 | Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue显示文摘 | Saunders RD Dugan LL Demediuk P | 1987 | J Neurochem1987，49，1： | 1 |
| 18 | Studies on magnesium and calcium oxychlorides显示文摘 | Demediuk T Cole W Hueber H | 1955 | Australian Journal of Chemistry1955，8，2： | 1 |
| 19 | Decrease in total and free magnesium concentration following traumatic brain injury in rats显示文摘 | Vink R Mclntosh JK Demediuk P | 1987 | Biochem Biophys Res Commun1987，149，： | 1 |
| 20 | A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter显示文摘 | Demediuk B Brand SJ | 1991 | Mol Cell Biol1991，1，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员