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		题名	作者	年代	出处	被引量
	1	ERK1/mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis显示文摘	Agrawal A Dillon S Denning T L Pulendran B		0，，：	1
	2	Comparison between two different concepts of lumbar posterior osteosynthesis implants A finite-element analysis显示文摘	Templier A Denninger L Mazel C	1998	Eur J Orthop Surg Traumatol1998，8，1：	1
	3	Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma显示文摘	Nickoloff BJ Qin JZ Chaturvedi V Denning MF Bonish B Miele L		0，，：	1
	4	Aetiological factors of Budd-Chiari syndrome in Algeria显示文摘AIM: To study the clinical presentation of Budd-Chiari syndrome(BCS) and identify the aetiologies of this disease in Algeria. METHODS: Patients with BCS, hospitalised in our unit from January 2004 until June 2010 were included and the aetiological factors were assessed. Patients presenting a BCS in the setting of advanced-stage cirrhosis or a liver transplantation were excluded from the study. The diagnosis was established when an obstruction of hepatic venous outflow(thrombosis, stenosis or compression) was demonstrated. We diagnosed myeloproliferative disease(MPD) by bone marrow biopsy and V617 F JAK2 mutation. Anti-phospholipid syndrome(APLS) was detected by the presence of anticardiolipin antibodies, anti-β2 glycoprotein antibodies and Lupus anticoagulant. We also detected paroxysmal nocturnal haemoglobinuria(PNH) by flow cytometry. Celiac disease and Behcet disease were systematically investigated in our patients. Hereditary anticoagulant protein deficiencies were also assessed. We tested our patients for the G20210 A mutation at Beaujon Hospital. Imaging procedures were performed to determine a local cause of BCS, such as a hydatid cyst or a liver tumour.RESULTS: One hundred and fifteen patients were included. Mean follow up: 32.12 mo. Mean age: 34.41 years, M/F = 0.64. Chronic presentation was frequent:63.5%. The revealing symptoms for the BCS were ascites(74.8%) and abdominal pain(42.6%). The most common site of thrombosis was the hepatic veins(72.2%). Involvement of the inferior vena cava alone was observed in 3 patients. According to the radiological investigations, BCS was primary in 94.7% of the cases(n = 109) and secondary in 5.2%(n = 6). An aetiology was identified in 77.4% of the patients(n = 89); it was multifactorial in 27%(n = 31). The predominant aetiology of BCS in our patients was a myeloproliferative disease, observed in 34.6% of cases. APLS was found in 21.7% and celiac disease in 11.4%. Other acquired conditions were: PNH(n = 4), systemic disease(n = 6) and inflammatory bowel disease(n = 5). Anticoagulant protein deficiency was diagnosed in 28% of the patients(n = 18), dominated by protein C deficiency(n = 13). Secondary BCS was caused by a compressing hydatic cyst(n = 5) and hepatocellular carcinoma(n = 1). CONCLUSION: The main aetiologic factor of BCS in Algeria is MPD. The frequency of celiac disease justifies its consideration when BCS is diagnosed in our region.	Nawel Afredj Nawal Guessab Abdelbasset Nani Sid Ahmed Faraoun Ibtissem Ouled Cheikh Rafik Kerbouche Djouhar Hannoun Zine Charef Amir Hayet Ait Kaci Kamel Bentabak Aurélie Plessier Dominique-Charles Valla Valerie Cazals-Hatem Marie-Hélène Denninger Tadjeddine Boucekkine Nabil Debzi	2015	World Journal of Hepatology2015，7，6：	1
	5	M-olecular mecha nisms of primary resistance to flucyto sine in candida albicans显示文摘	HOPE W W TABERNERO L DENNING D W		0，，11：	1
	6	Bleeding in patients with Budd-Chiari syndrome显示文摘	Rautou PE Douarin L Denninger MH		Journal of Hepatology0，，：	1
	7	Lactobacillus rhamnosus(LGG)regulates IL-10 signaling in the developing murine colon throughupregulation of the IL-10R2 receptor subunit显示文摘	Mirpuri J Sotnikov I Myers L Denning	2012	PLoS ONE2012，7，：	1
	8	Bleeding in patients with Budd-Chiari syndrome 显示文摘	Rautou PE Douarin L Denninger MH	2011	J Hepatol2011，54，1：	1
	9	Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells显示文摘	Denning T L Takaishi H Crowe S E		0，，12：	1

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