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| 1 | CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia显示文摘AIM:To compare the sensitivity and specificity of CDX2 and alcian blue(AB) p H 2.5 staining in identifying esophageal intestinal metaplasia.METHODS:One hundred and ninty-nine biopsies from 186 patients were retrospectively reviewed and categorized as Barrett's esophagus(BE)(n =108); non-Barrett's esophagus(NBE)(n =48); columnar blue cells(CB) and esophageal glands(EG)(n =43).The biopsies were stained with AB and immunostained for CDX2 using a mouse monoclonal antibody from Biogenex(clone CDX2-88) and the Ventana Discovery X automated immunostainer.The positive and negative predictive value of each group was used to determine the predictive power of CDX2 and AB in diagnosing intestinal metaplasia.RESULTS:All of the 108 BE biopsies(100%) were positive for AB and 102 of them(94.4%) were positive for CDX2.The six BE patients(5.6%) who failed to stain with CDX2 were found to have lost the focus of intestinal metaplasia upon deeper sectioning for immunostaining.Both AB and CDX2 were negative in 43 out of 48(89.6%) NBE cases.Five NBE patients(10.4%) were falsely positive for AB due to the presence of EG and CB in these biopsies.These cases were all CDX2 negative.In addition,5 AB negative NBE were found to be CDX2 positive.Based on these results the CDX2 immunostain had similar sensitivity but higher specificity(100% vs about 91%) than AB in detecting intestinal type metaplasia in these samples.Our data shows that CDX2 has a better PPV in detecting intestinal metaplasia as compared to AB(95.6% vs 71.5%,respectively).CONCLUSION:CDX2 has a better positive predictive value than AB in detecting intestinal metaplasia.CDX2may be useful when challenged by gastro-esophageal biopsies containing mimikers of BE. | Dennis R Johnson Maisoun Abdelbaqui Maryam Tahmasbi Zoltan Mayer Hung-Wei Lee Mokenge P Malafa Domenico Coppola | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | Ketamine use disorder:preclinical,clinical,and neuroimaging evidence to support proposed mechanisms of actions显示文摘Ketamine,a noncompetitive N-methyl-D-aspartate(NMDA)receptor antagonist,has been exclusively used as an anesthetic in medicine and has led to new insights into the pathophysiology of neuropsychiatric disorders.Clinical studies have shown that low subanesthetic doses of ketamine produce antidepressant effects for individuals with depression.However,its use as a treatment for psychiatric disorders has been limited due to its reinforcing effects and high potential for diversion and misuse.Preclinical studies have focused on understanding the molecular mechanisms underlying ketamine’s antidepressant effects,but a precise mechanism had yet to be elucidated.Here we review different hypotheses for ketamine’s mechanism of action including the direct inhibition and disinhibition of NMDA receptors,aminomethylphosphonic acid receptors(AMPAR)activation,and heightened activation of monoaminergic systems.The proposed mechanisms are not mutually exclusive,and their combined influence may exert the observed structural and functional neural impairments.Long term use of ketamine induces brain structural,functional impairments,and neurodevelopmental effects in both rodents and humans.Its misuse has increased rapidly in the past 20 years and is one of the most common addictive drugs used in Asia.The proposed mechanisms of action and supporting neuroimaging data allow for the development of tools to identify‘biotypes’of ketamine use disorder(KUD)using machine learning approaches,which could inform intervention and treatment. | Leah Vines Diana Sotelo Allison Johnson Evan Dennis Peter Manza Nora D.Volkow Gene-Jack Wang | 2022 | Intelligent Medicine2022，2，2： | 2 |
| 3 | The relative importance of graft surveillance and warfarin therapy in infrainguinal prosthetic bypass failure显示文摘 | Robert Scott Brumberg Martin R. Back Paul A. Armstrong David Cuthbertson Murray L. Shames Brad L. Johnson Dennis F. Bandyk | 2007 | Journal of Vascular Surgery2007，，： | 2 |
| 4 | Deposition and redistribution of fungicides applied by air and chemigation for control of late blight in commercial potato显示文摘 | BRAD GEARY PHILIP B HAMM DENNIS A JOHNSON | 2008 | Americal Journal of Patato to Research2008，81，5： | 1 |
| 5 | Transferring personal and social responsibility of underserved youth to the classroom显示文摘 | Tammy Schilling Dennis Johnson | 2002 | The Urban Review2002，33，1： | 1 |
| 6 | Extracardiac findings on coronary CT angiograms:limited versus complete image review显示文摘 | Johnson KM Dennis JM Dowe DA | 2010 | Am J Roentgen2010，195，1： | 1 |
| 7 | Controlled expression and functional analysis of iron- sulfur cluster biosynthetic components with Azotobacter vinelandii显示文摘 | Deborah C Johnson Mihaela-Carmen Unciuleac Dennis R Dean | 2006 | Journal of Bacteriology2006，，： | 1 |
| 8 | Long-term survival after vascular surgery: Specific influence of cardiac factors and implications for preoperative evaluation显示文摘 | Martin R. Back Fabian Leo David Cuthbertson Brad L. Johnson Murray L. ShamesMD Dennis F. Bandyk | 2004 | Journal of Vascular Surgery2004，，4： | 1 |
| 9 | Electrocatalysis of anodic oxygen - transfer reactions:oxidation of Cr( Ⅲ) to Cr ( Ⅵ ) at Bi ( Ⅴ ) - doped PbO2 - film electrodes显示文摘 | Kim L Pamplin Dennis C Johnson | 1996 | Electrochemical Society1996，143，7： | 1 |
| 10 | Nitrogen and potassium fertility afects jala peno pepper plant growth, pod yield and pungenoy显示文摘 | Charles D Johnson Dennis R Deeoteall | 1996 | Hortseienee1996，31，7： | 1 |
| 11 | The john insall award: control - matched evaluation of painful patellar crepitus after total knee arthroplasty显示文摘 | Dennis DA Kim RH Johnson DR | 2011 | Clin Orthop2011，1，： | 1 |
| 12 | Magnetic resonance imaging characteristics of suspected vertebral instability associated with fracture or subluxation in eleven dogs显示文摘 | Johnson P Beltran E Dennis R | | 0，，05： | 1 |
| 13 | Rupestris Stem Pitting Associated Virus-1 is Consistently Detected in Grapevines that are Infected with Rupestris Stem Pitting显示文摘 | Baozhong Meng Ray Johnson Silvano Peressini Philip L. Forsline Dennis Gonsalves | 1999 | European Journal of Plant Pathology1999，，2： | 1 |
| 14 | Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis显示文摘 | Y. M. Dennis Lo Mark S.C. Tein Tze K. Lau Christopher J. Haines Tse N. Leung Priscilla M.K. Poon James S. Wainscoat Philip J. Johnson Allan M.Z. Chang N. Magnus Hjelm | 1998 | The American Journal of Human Genetics1998，，4： | 1 |
| 15 | Critical Analysis of Outcome Determinants Affecting Repair of Intact Aneurysms Involving the Visceral Aorta显示文摘 | Martin R. Back MD Matthew Bandyk Michael Bradner BS David Cuthbertson MS Brad L. Johnson MD Murray L. Shames MD Dennis F. Bandyk MD | 2005 | Annals of Vascular Surgery2005，，5： | 1 |
| 16 | Dioctyl sulfosuccinate analysis in near-shore Gulf of Mexico water by direct-injection liquid chromatography–tandem mass spectrometry显示文摘 | Johnson Mathew David L. Schroeder Lawrence B. Zintek Caitlin R. Schupp Michael G. Kosempa Adam M. Zachary George C. Schupp Dennis J. Wesolowski | 2012 | Journal of Chromatography A2012，，： | 1 |
| 17 | The importance of anodic discharge of H2O in anodic oxygen-transfer reactions显示文摘 | Dennis C Johnson | 1992 | J Electrochem Soc1992，，139： | 1 |
| 18 | Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis显示文摘 | Y. M. Dennis Lo Mark S.C. Tein Tze K. Lau Christopher J. Haines Tse N. Leung Priscilla M.K. Poon James S. Wainscoat Philip J. Johnson Allan M.Z. Chang N. Magnus Hjelm | 1998 | The American Journal of Human Genetics1998，，4： | 1 |
| 19 | Phase-locked interferometry显示文摘 | Johnson G Lin W Dennis C Leinor Dancan T Mane | 1977 | SPIE Proc1977，126，： | 1 |
| 20 | Electrofusion of a Weakly Immunogenic Neuroblastoma with Dendritic Cells Produces a Tumor Vaccine显示文摘 | Rimas J. Orentas Dennis Schauer Qian Bin Bryon D. Johnson | 2001 | Cellular Immunology2001，，： | 1 |
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