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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Detection of cytokines in human sural nerve biopsies:an immunohistochemical and molecular study显示文摘 | Lubke U Verlaet M | 2001 | Acta Neuropathol2001，101，4： | 1 |
| 3 | Spiral CT cholangiography of choledochocele显示文摘 | Galeon M Deprez P Wan-Beers B E | 1996 | J-Comput-Assist-Tomogr1996，20，5： | 1 |
| 4 | Trends in PACS architecture显示文摘 | Bellon E Feron M Deprez T | 2011 | Eur J Radiol2011，78，： | 1 |
| 5 | Comparative study of commercially available anti-alpha-synuclein antibodies显示文摘 | Croisier E MRes D E Deprez M | 2006 | Neuropathol Appl Neurobiol2006，32，： | 1 |
| 6 | Physio- logical and proteomic responses to single and repeated hypoxia in juvenile Eurasian perch under domestica- tion-clues to physiological acclimation and humoral immune modulations显示文摘 | Douxfils J Deprez M Mandiki S N M | 2012 | Fish and Shellfish Immunol- ogy2012，33，5： | 1 |
| 7 | Sensitivity and accuracy of quantitative realtime polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions 显示文摘 | LEKANNE DEPREZ R H FIJNVANDRAAT A C RUI JTER J M | 2002 | Analytical Biochemistry2002，307，： | 1 |
| 8 | The veno- occlusive disease of the liver显示文摘 | Deprez M Beguin Y | 1997 | Haematologica1997，82，6： | 1 |
| 9 | The veno-occlusive disease of the liver显示文摘 | Baron F Deprez M Beguin Y | 1997 | Haematologica1997，82，6： | 1 |
| 10 | Cholestatic syndrome due to preservation injury after liver transplantation显示文摘 | Adler M Deprez C Rickaert F | 1988 | Transplant Proc1988，20，4： | 1 |
| 11 | Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy 显示文摘 | Zattoni M Mura ML Deprez F | 2011 | Neu- rosci2011，31，11： | 1 |
| 12 | The apoptosis of osteoblasts and osteocytes in femoral head osteonecrosis :its specificity and its distribution 显示文摘 | Mutijima E De Maertelaer V Deprez M | 2014 | Clin Rheumatol2014，33，12： | 1 |
| 13 | Assumption-free analysis of quantitative real-time polymerase chain reac-tion(PCR)data显示文摘 | Ramakers C Ruijter J M Deprez R H | | Neurosci Lett0，339，1： | 1 |
| 14 | Absence of hypo- gonadism in a male patient with a giant prolactinoma: a clinical paradox 显示文摘 | Tamagno G Daly AF Deprez M | 2008 | Ann Endocrinol (Paris)2008，69，7： | 1 |
| 15 | Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro显示文摘 | DEPREZ E BARBE S KOLASKI M | 2004 | Mol Pharmacol2004，65，1： | 1 |
| 16 | Cholestatic syndrome due to preservation injury after liver transplantation显示文摘 | Adler M Deprez C Richaert | 1988 | Transplant Prec1988，20，： | 1 |
| 17 | The veno-occlusive disease of the liver 显示文摘 | Baron F Deprez M Beguin Y | 1997 | Haematologica1997，826，： | 1 |
| 18 | Cholestatic syndrome due to preservation injury after liver transpantation显示文摘 | Deprez C Rickaert F | 1988 | Transplant Proc1988，20，4： | 1 |
| 19 | Trends in PACS architecture显示文摘 | Bellon E Feron M Deprez T | 2011 | Eur J Radiol2011，78，2： | 1 |
| 20 | Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data显示文摘 | Ramakers C Ruijter J M Deprez R H | 2003 | Neurosci Lett2003，339，1： | 1 |
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