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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review显示文摘AIM To summarise the literature data on hepatitis C virus(HCV)-infected patients concerning the prevalence of glucose abnormalities and associated risk.METHODS We conducted a PubM ed search and selected all studies found with the key words 'HCV' or 'hepatitis C virus' and 'diabetes' or 'insulin resistance'. We included only comparative studies written in English or in French, published from January 2000 to April 2015. We collected the literature data on HCV-infected patients concerning the prevalence of glucose abnormalities [diabetes mellitus (DM) and insulin resistance (IR)] and associated risk [i.e., severe liver fibrosis, response to antivirals, and the occurrence of hepatocellular carcinoma(HCC)]. RESULTS HCV infection is significantly associated with DM/IR compared with healthy volunteers and patients with hepatitis B virus infection. Glucose abnormalities were associated with advanced liver fibrosis, lack of sustained virologic response to interferon alfa-based treatment and with a higher risk of HCC development. As new antiviral therapies may offer a cure for HCV infection, such data should be taken into account, from a therapeutic and preventive point of view, for liver and non-liver consequences of HCV disease. The efficacy of antidiabetic treatment in improving the response toantiviral treatment and in decreasing the risk of HCC has been reported by some studies but not by others. Thus, the effects of glucose abnormalities correction in reducing liver events need further studies.CONCLUSION Glucose abnormalities are strongly associated with HCV infection and show a negative impact on the main liver related outcomes. | Anne-Claire Desbois Patrice Cacoub | 2017 | World Journal of Gastroenterology2017，23，9： | 14 |
| 3 | Antibacterial free fatty acids:activities, mechanisms of action and biotechnological potential 显示文摘 | Desbois A P Smith V J | 2010 | Applied Microbiol and Biotechnology2010，85，6： | 1 |
| 4 | Antibacterial Free Fatty Acids : activities, Mechanisms of Action and Biotechnological显示文摘 | ANDREW P DESBOIS V J | 2010 | Application Microbiology and Biotechnology2010，85，6： | 1 |
| 5 | Long-term outcome of idiopathic pulmonary hemosiderosis in children 显示文摘 | Le Clainche L Le Bourgeois M Fauroux B Forenza N Dommergues JP Desbois JC | 2000 | Medicine(Baltimore)2000，79，5： | 1 |
| 6 | Neuropilin-1is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo显示文摘 | JIANG SX SHELDRICK M DESBOIS A | 2007 | Mol Cell Biol2007，27，5： | 1 |
| 7 | Increased bone formation in osteocal- cin - deficient mice 显示文摘 | Ducy P Desbois C Boyce B | 1996 | Nature1996，382，6590： | 1 |
| 8 | teocalcin cluster: implications for functional studies 显示文摘 | Desbois C Karsenty G | 1995 | J Cell Biochem1995，57，3： | 1 |
| 9 | Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation显示文摘 | Zappulla JP Dubreuil P Desbois S | 2005 | J Exp Med2005，202，12： | 1 |
| 10 | The CCKB/gastrin receptor is coupled to the regulation of enzyme secretion,protein synthesis and p70 S6 kinase activity in acinar ceils from ElasCCKB transgenic mice 显示文摘 | Desbois C Huerou-Luron I L Dufresne M | 1999 | Eur J Biochem1999，266，3： | 1 |
| 11 | Antibacterial Free Fatty Acids:activities,Mechanisms of Action and Biotechnological Potential显示文摘 | DESBOIS A P SMITH V J | 2010 | Applied Microbiology and Biotechnology2010，85，6： | 1 |
| 12 | Conventional and unconventional antimicro-bials from fish, marine invertebrates and microalgae 显示文摘 | Smith V J Desbois A P Dyrynda E A | 2010 | Marine Drugs2010，8，4： | 1 |
| 13 | Inhibition of p 38 MAPK by glucocorticoids via induction of MAPK phosphatase - 1 enhances nontypeable Haemophilus inlluenzae - induced expression of toll - like receptor 2 显示文摘 | Imasato A Desbois - Mouthon C Han J | 2002 | J Biol Chem2002，277，49： | 1 |
| 14 | Increased bone forma- tion in osteocalcin-deficient mice 显示文摘 | Ducy P Desbois C Boyce B | 1996 | Nature1996，382，： | 1 |
| 15 | Usefulness of specific lgG avid-ity for diagnosis of hepatitis A infection显示文摘 | Desbois D Grangeot-Keros L Roquebert B | 2005 | Gastroenterol Clin Biol2005，29，： | 1 |
| 16 | Transparent mixtures of styrene-butadiene block copolymers 显示文摘 | Desbois P Riddy C Knoll K | 1993 | Modern Plastic1993，28，4： | 1 |
| 17 | Satellite Detection of Saharan Dust:Optimized Imaging During Nighttime显示文摘 | Legrand M Desbois M Vovor K | 1988 | Journal of Climate1988，1，3： | 1 |
| 18 | Anaerobic disgestion of municipal solid organic waste: Valorgafull-scale plant in Tilburg, the Netherlands 显示文摘 | Laclos H F Desbois S Saint Joly C | 1997 | Water Science and Technology1997，36，6： | 1 |
| 19 | BIB-SEM study of the pore space morphology in early mature Posidonia Shale from the Hils area,Germany显示文摘 | Klaver J Desbois G Urai J L | 2012 | International Journal of Coal Geology2012，103，： | 1 |
| 20 | Determinant impact of waste collection and composition on anaerobic digestion performance:industrial results显示文摘 | Saint-Joly C Desbois S Lotti J P | 2000 | Water Sci Tech2000，41，3： | 1 |
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