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| 1 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 2 | Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology显示文摘 | Dewar R Fadare O Gilmore H | 2011 | Arch Pathoi Lab Med2011，135，4： | 1 |
| 3 | The Correspondence Between the Resonance and Molecular Orbital Theory 显示文摘 | Dewar M J S Longuet-Higgins H C | 1952 | Proc Roy Soc1952，214，： | 1 |
| 4 | Cisplatin neuropathy withLhermitte's sign显示文摘 | Dewar J Lunt H Abernethy DA | 1986 | J Neurol Neurosurg Psychiatry1986，49，1： | 1 |
| 5 | Bortezomib treatment causes remission in a Ph+ALL patient and re-veals FoxO as a theranostic marker 显示文摘 | Dewar R Chen ST Yeckes-Rodin H | 2011 | Cancer Biol Ther2011，11，6： | 1 |
| 6 | Anastomotic aneurysms: facts and fancy显示文摘 | Gaylis H Dewar G | 1990 | Surg Annu1990，22，： | 1 |
| 7 | Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia显示文摘 | Imai H Masayasu H Dewar D | 2001 | Stroke2001，32，： | 1 |
| 8 | Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia显示文摘 | Imai H Masayasu H Dewar D | 2001 | Stroke2001，32，9： | 1 |
| 9 | Aspects of shark swimming performance determined using a large water tunnel显示文摘 | Graham J B Dewar H Lai N C | 2004 | J Exp Biol2004，151，： | 1 |
| 10 | Migratory movements,depth preferences,and thermal biology of Atlantic blufin tuna显示文摘 | Block B A Dewar H Blackwell S B | | 0，，293： | 1 |
| 11 | Epithelial tumour cells in the lungs of sheep with pulmonary adenomatosis are major sites of replication for Jaagsiekte retrovirus 显示文摘 | Palmarini M Dewar P Marcelo L H | 1995 | J Gen Virol1995，76，11： | 1 |
| 12 | Vertical ionization potentials of radicals by the MINDo/3 method 显示文摘 | DEWAR M J S KOLLMAR H W | 1975 | Theoret China Acta1975，36，： | 1 |
| 13 | Aspects of shark swimming performance determined using a large water tunnel 显示文摘 | Graham J B Dewar H Lai N C | 1990 | J Exp Biol1990，151，： | 1 |
| 14 | Best practices in diagnostic immunohistochemistry:myoepithelial markers in breast pathology 显示文摘 | Dewar R Fadare O Gilmore H | 2011 | Arch Pathol Lab Med2011，135，4： | 1 |
| 15 | Annual migrations, diving behavior, and thermal biology of Atlantic bluefin tuna, Thunnus thynnus, on their Gulf of Mexico breeding grounds显示文摘 | Teo S L H Boustany A Dewar H | 2007 | Marine Biology2007，151，1： | 1 |
| 16 | Comparisons of granular pesticides for the control of soil-inhabiting arthropod pests of sugar beet显示文摘 | WINDER G H DEWAR A M DUNNING R A | 1993 | Crop Protection1993，12，2： | 1 |
| 17 | A new satellite technology for tracking the movements of Atlantic bluefin tuna显示文摘 | Block B A Dewar H Farwell C | | 0，，： | 1 |
| 18 | Depth and muscle temperature of Pacific bluefin tuna examined with acoustic and pop-up satellite archival tags显示文摘 | Marcinek D J Blackwell S B Dewar H | | 0，，04： | 1 |
| 19 | Basic concepts relevant to heat transfer in fishes,and their use in measuring the physiological thermoregulatory abilities of tunas显示文摘 | Brill R W Dewar H Graham J B | 1994 | Envir Biol Fish1994，40，： | 1 |
| 20 | Cireumstanees attending 100sudden cardiac deaths from coronary artery disease Witllcoroner’Snecmpies显示文摘 | Myers A Dewar H L A | 1975 | British Heart Journal1975，，57： | 1 |
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