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| 1 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 2 | Use of clopidogrel with or without aspirin in patients taking oral an- ticoagulant therapy and undergoing percutaneous coronary in- tervention: an open label, randomized, controlled trial 显示文摘 | Dewilde W J M Oirbans T Verheugt F W A | 2013 | Lancet2013，381，9872： | 1 |
| 3 | Use of clopidogrel with or without aspirin in pa- tients taking oral anticoagulant therapy and undergo- ing percutaneous coronary intervention: an open:la- bel, randomised, controlled trial显示文摘 | DEWILDE W J OIRBANS T VERHEUGT F W | 2013 | Lancet2013，381，： | 1 |
| 4 | Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding 显示文摘 | Uzan J Dewilde S Burmester T | 2004 | Biophys2004，87，2： | 1 |
| 5 | Impact of omalizumab on quality-of-life outcomes in patients with moderate to severe allergic asthma 显示文摘 | Niebauer K Dewilde S Fox-Rushby J | 2006 | Ann Allergy Asthma Immunol2006，96，6： | 1 |
| 6 | The Challenging World of Biofilm Physiology显示文摘 | Donné J Dewilde S | 2015 | Adv Microb Physiol2015，67，： | 1 |
| 7 | Subspace model identification part Ⅰ:the output-error state-space model identification class of algorithms显示文摘 | Verhaegen M Dewilde J | 1992 | International Journal of Control1992，56，5： | 1 |
| 8 | Neuroglobin in the rat brain (Ⅱ):co-localisation with neurotransmitters显示文摘 | Hundahl CA Kelsen J Dewilde S | | 0，，： | 1 |
| 9 | Use of clopi- dogrel with or without aspirin in patients taking oral anticoag- ulant therapy and undergoing percutaneous coronary inter- vention: an open-label, randomised, controlled trial 显示文摘 | Dewilde W J Oirbans T Verheugt F W | 2013 | Lancet2013，381，9872： | 1 |
| 10 | Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention:an open-label,randomized,controlled trial显示文摘 | DEWILDE W J OIRBANS T VERHEUGT F WOEST study investigators | 2013 | Lancet2013，381，： | 1 |
| 11 | Planning for resilience:modehng change in human-fire interactions in the Alaskan boreal forest显示文摘 | Chapin FS Rupp TS Starfield AM DeWilde LO Zaveleta ES Fresco N Henkelman J McGuire AD | | 0，，： | 1 |
| 12 | Use of elopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention : an open-label, randomised, controlled trial 显示文摘 | Dewilde W J M Oirbans T Verheugt F W A etal | 2013 | Lancet2013，381，9872： | 1 |
| 13 | ALD barrier deposition on porous Iow-k dielectric materials for interconnects 显示文摘 | ELSHOCHT S V DELABIE A DEWILDE S MEERSSCHAUT J SWERTS J TIELENS H VERDONCK R WITTERS T VANCOILLE E | 2011 | ECS Transactions2011，41，2： | 1 |
| 14 | Opening wedge distal femoral varus osteotomy using the Puddu plate and calcium phosphate bone cement显示文摘 | Dewilde TR Dauw J Vandenneucker H | 2013 | Knee Surg Sports Traumatol Arthrosc2013，21，1： | 1 |
| 15 | Opening wedge distal femoral vm'us osteotomy using the Puddu plate and calcium phos- phate bone cement 显示文摘 | Dewilde TR Dauw J Vnndenneueker H | 2013 | Knee Surg Sports Traumatol Arthrosc2013，21，1： | 1 |
| 16 | Understanding and correcting for carbon nanotube interferences with a commercial LDH cyiotoxic- ity assay显示文摘 | WANG G ZYIANG J P DEWILDE A H | 2012 | Toxicology2012，299，23： | 1 |
| 17 | Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention:an open-label,randomised,controlled trial显示文摘 | Dewilde W J M Oirbans T Verheugt F W A | 2013 | Lancet2013，381，9872： | 1 |
| 18 | Neuroglobin and Other Hexacoordinated Hemoglobins Show a Weak Temperature Dependence of Oxygen Binding 显示文摘 | Uzan J Dewilde S Burmester T | 2004 | Biophys J2004，87，2： | 1 |
| 19 | Cephalic subcutaneous metastases from a urinary bladder carcinoma显示文摘 | Wyndaele J J Dewilde T | 1997 | Acta Urol Belg1997，65，4： | 1 |
| 20 | Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention:an open-label,randomised,controlled trial显示文摘 | Dewilde W J Oirbans T Verheugt FW | | 0，，9872： | 1 |
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