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| 1 | Comparative effectiveness of traditional chemoembolization with or without sorafenib for hepatocellular carcinoma显示文摘AIM: To compare the overall survival (OS) and progression-free survival (PFS) with associated adverse events (AE) in patients with unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) + sorafenib vs TACE alone. METHODS: In this retrospective cohort study we collected data on all consecutive patients with a diagnosis of unresectable HCC between 2007 and 2011 who had been treated with TACE + sorafenib or TACE alone. We hypothesized that the combination therapy is superior to TACE alone in improving the survival in these patients. Data extracted included patient's demographics, etiology of liver disease, histology of HCC, stage of liver disease with respect to model of end stage liverdisease score and Child-Turcotte-Pugh (CTP) classification and Barcelona Clinic Liver Cancer (BCLC) staging for HCC. Computed tomography scan findings, alpha fetoprotein levels, number of treatments and related AE were also recorded and analyzed. RESULTS: Of the 43 patients who met inclusion criteria, 13 were treated with TACE + sorafenib and 30 with TACE alone. There was no significant difference in median survival: 20.6 mo (95%CI: 13.4-38.4) for the TACE + sorafenib and 18.3 mo (95%CI: 11.8-32.9) for the TACE alone (P = 0.72). There were also no statistically significant differences between groups in OS (HR = 0.82, 95%CI: 0.38-1.77; P = 0.61), PFS (HR = 0.93, 95%CI: 0.45-1.89; P = 0.83), and treatment-related toxicities (P = 0.554). CTP classification and BCLC staging for HCC were statistically significant (P = 0.001, P = 0.04 respectively) in predicting the survival in patients with HCC. The common AE observed were abdominal pain, nausea, vomiting and mild elevation of liver enzymes. CONCLUSION: Combination therapy with TACE + sorafenib is safe and equally effective as TACE alone in patients with unresectable HCC. CTP classification and BCLC staging were the significant predictors of survival. Future trials with large number of patients are needed to further validate this observation. | Adnan Muhammad Manish Dhamija Gitanjali Vidyarthi Donald Amodeo William Boyd Branko Miladinovic Ambuj Kumar | 2013 | World Journal of Hepatology2013，5，7： | 16 |
| 2 | Role of contrast enhanced ultrasound in hepatic imaging 显示文摘 | Dhamija E Paul SB | 2014 | Trop Gastroenterol2014，35，3： | 1 |
| 3 | Novel de novo SPOCK1 mutation in a proband with developmental delay, microcephaly and agenesis of corpus callosum 显示文摘 | Dhamija R Graham JM Smaoui N | 2014 | Eur J Med Genet2014，57，4： | 1 |
| 4 | Homocysteine and lipoprotein (a) correlation in ischemic stroke patients显示文摘 | DHAMIJA R K GABA P ARORA S | 2009 | J Neurol Sci2009，281，12： | 1 |
| 5 | Can eytomorphology of granulomas distinguish sarcoidosis from tuberculosis retrospective study of endobronchial ultrasound guided transbronehial needle aspirate of 49 granulomatous lymph ndes显示文摘 | Kaur G Dhamija A Augustine J | 2013 | Cytojournal2013，10，： | 1 |
| 6 | Homocysteine and lipopro- tein(a) correlation in ischemic stroke patients 显示文摘 | Dhamija RK Gaba P Arora S | 2009 | J Neurol Sci2009，281，12： | 1 |
| 7 | Incidence and risk factors of hepatocellular carcinoma in patients with hepatic venous outflow tract obstruction显示文摘 | S. B. Paul Shalimar V. Sreenivas S. R. Gamanagatti H. Sharma E. Dhamija S. K. Acharya | 2015 | Aliment Pharmacol Ther2015，，10： | 1 |
| 8 | Homocysteine and lipoprotein (a) correlation in ischemic stroke patients 显示文摘 | Dhamija RK Gaba P Arora S | 2009 | J Neurol Sci2009，281，12： | 1 |
| 9 | Role of Cbfal in ameloblastin gene transcription 显示文摘 | Dhamija S Krebsbach PH | 2001 | J Biol Chem2001，276，35： | 1 |
| 10 | Metformin : Midiife maturity, maiden charm显示文摘 | Kalra S Dhamija P Das AK | 2012 | Indian J Endocrinol Metab2012，16，6： | 1 |
| 11 | Auditory evoked response in patients of diabetes mellitus 显示文摘 | MUKHOPADHYAY S DHAMIJA R M SELVAMURTHY W | 1992 | Indian J Med Res1992，14，4： | 1 |
| 12 | Epilepsy in children: when should we think neurometabolic disease? 显示文摘 | Dhamija R Patterson MC Wirrell EC | 2012 | J Child Neurol2012，27，5： | 1 |
| 13 | Characterisation of the specific p-nitrophenylphosphatase gene and protein of Schizosaccharomyces pombe显示文摘 | Yang J W Dhamija S S Schweingruber M E | 1991 | Eur J Biochem1991，198，2： | 1 |
| 14 | Ethnicity and body mass index are associated with hepatitis C presentation and progression显示文摘 | Kallwitz ER Layden-Almer J Dhamija M | 2010 | Clin Gastroenterol Hepatol2010，8，1： | 1 |
| 15 | Moxifloxacin induced fatal hepato- toxicity in a 72 - year - old man: a case report 显示文摘 | Verma R Dhamija R Batts DH | 2009 | Cases J2009，2，： | 1 |
| 16 | Role of Cbfal in ameloblastin gene transcription显示文摘 | Dhamija S Krebsbach PH | 2001 | J Biol Chem2001，276，35： | 1 |
| 17 | A user study using images for authentication显示文摘 | Rachna Dhamija rachna Adrian Perrig Déjà Vu | 2005 | Proceedings of the 9th USENIX Security Symposium2005，9，2： | 1 |
| 18 | Cloning and characterization of the murine ameloblastin promoter显示文摘 | DHAMIJA S LIU Y YAMADA Y | 1999 | Biolchemistry1999，274，20： | 1 |
| 19 | Role of Cbfal in amelo- blastin gene transcription 显示文摘 | DHAMIJA S REBSBACH PH | 2001 | Biochemistry2001，276，35： | 1 |
| 20 | Historic,clinical,and prognostic features of epileptic encephalopathies caused by cdkl5 mutations显示文摘 | Moseley BD Dhamija R Wirrell EC | | 0，，02： | 1 |
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