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| 1 | The emergence of pandemic influenza viruses显示文摘Pandemic influenza has posed an increasing threat to public health worldwide in the last decade.In the 20th century,three human pandemic influenza outbreaks occurred in 1918,1957 and 1968,causing significant mortality.A number of hypotheses have been proposed for the emergence and development of pandemic viruses,including direct introduction into humans from an avian origin and reassortment between avian and previously circulating human viruses,either directly in humans or via an intermediate mammalian host.However,the evolutionary history of the pandemic viruses has been controversial,largely due to the lack of background genetic information and rigorous phylogenetic analyses.The pandemic that emerged in early April 2009 in North America provides a unique opportunity to investigate its emergence and development both in human and animal aspects.Recent genetic analyses of data accumulated through long-term influenza surveillance provided insights into the emergence of this novel pandemic virus.In this review,we summarise the recent literature that describes the evolutionary pathway of the pandemic viruses.We also discuss the implications of these findings on the early detection and control of future pandemics. | Yi Guan Dhanasekaran Vijaykrishna Justin Bahl Huachen Zhu Jia Wang Gavin J.D.Smith | 2010 | Protein & Cell2010，1，1： | 16 |
| 2 | Nonsaturation Throughput Enhancement of IEEE 802.11b Distributed Coordination Function for Heterogeneous Traffic under Noisy Environment显示文摘In this paper, we propose a mechanism named modified backoff (MB) mechanism to decrease the channel idle time in IEEE 802.11 distributed coordination function (DCF). In the noisy channel, when signal-to-noise ratio (SNR) is low, applying this mechanism in DCF greatly improves the throughput and lowers the channel idle time. This paper presents an analytical model for the performance study of IEEE 802.11 MB-DCF for nonsaturated heterogeneous traffic in the presence of transmission errors. First, we introduce the MB-DCF and compare its performance to IEEE 802.11 DCF with binary exponential backoff(BEB). The IEEE 802.11 DCF with BEB mechanism suffers from more channel idle time under low SNR. The MB-DCF ensures high throughput and low packet delay by reducing the channel idle time under the low traffic in the network. However, to the best of the authors knowledge, there are no previous works that enhance the performance of the DCF under imperfect wireless channel. We show through analysis that the proposed mechanism greatly outperforms the original IEEE 802.11 DCF in the imperfect channel condition. The effectiveness of physical and link layer parameters on throughput performance is explored. We also present a throughput investigation of the heterogeneous traffic for different radio conditions. | Dhanasekaran Senthilkumar A. Krishnan | 2010 | International Journal of Automation and computing2010，7，1： | 5 |
| 3 | Phylogenetic analysis and protective effects of thymol and its chromatographic fractions from a novel wild mushroom in combating oxidative stress显示文摘Mushrooms are good sources of phytochemicals that have antioxidant and anti-proliferative effects.This study identifi ed a unique isoform of 18S rRNA gene(864 bp)from a novel wild mushroom(SMK-1)(GenBank accession number:SUB3267363).Thin layer chromatographic(TLC)profiling of the methanolic extract of the dried mushroom fruiting bodies of SMK-1 revealed the presence of phenolic and fl avonoid fractions with retention factor(Rf)values of 0.955 and 0.927 respectively.The GC/MS chromatograms of the SMK-1 methanolic extract identifi ed the main bioactive compound was phenol,5-methyl-2-(1-methylethyl)(74.00%)(thymol).The radical scavenging activity for the fl avonoid fraction was greater than the phenolic fractions(Rf–phenolics fractions>Rf–fl avonoid fractions)with the antioxidant activity more than that of standard ascorbic acid.Also,the phenolic and flavonoid fractions of SMK-1 expressed cytotoxic effects in HeLa cells with IC50 values ranging from 5μg/mL to 80μg/mL in a dose-dependent manner.This present research highlights the presence of high thymol concentration in a novel wild mushroom that has antioxidant and anti-poliferative potential with therapeutic benefi ts.The application of thymol natural products from novel mushroom SMK-1 as nutrition supplements could inhibit oxidative stress triggered by numerous pathologies that may pave the way to develop a new therapeutic natural drug. | M.Subbulakshmi Sugapriya Dhanasekaran S.Abirami M.Kannan R.Palaniappan Divya Venugopal | 2021 | Food Science and Human Wellness2021，10，4： | 2 |
| 4 | Delineation of prognostic biomarkers in prostate cancer显示文摘 | Dhanasekaran SM Barrrette TR Ghosh D | | 0，，： | 2 |
| 5 | Larvicidal,ovicidal and pupicidal activities of Gliricidia sepium(Jacq.)(Leguminosae) against the malarial vector,Anopheles stephensi Liston(Culicidae:Diptera)显示文摘Objective:To investigate the potentiality of mosquitocidal activity of Gliricidia sepium(C.sepium) (Jacq.)(Leguminosae).Methods:Twenty five early third instar larvae of Anopheles stephensi (An.stephensi) were exposed to various concentrations(50-250 ppm) and the 24 h LC50 values of the G.sepium extract was determined by probit analysis.The ovicidal activity was determined against An.stephensi to various concentrations ranging from 25-100 ppm under laboratory conditions.The eggs hatchabilily was assessed 48 h post treatment.The pupicidal activity was determined against An.stephensi to various concentrations ranging from 25-100 ppm.Mortality of each pupa was recorded after 24 h of exposure to the extract.Results:Results pertaining to the experiment clearly revealed that ethanol extract showed significant larvicidal,ovicidal and pupicidal activity against the An.stephensi.Larvicidal activity of ethanol extracts of G.sepium showed maximum mortality in 250 ppm concentration(96.0±2.4)%.Furthermore,the LC50 was found to be 121.79 and the LC50 value was recorded to be 231.98 ppm.Ovicidal activity of ethanol extract was assessed by assessing the egg hatchabilily.Highest concentration of both solvent extracts exhibited 100%ovicidal activity.Similarly,pupae exposed to different concentratioiLs of ethanol extract were found dead with 58.10%adult emergence when it was treated with 25 ppm concentration.Similarly,18.36(n=30;61.20%);21.28(70.93) and 27.33(91.10) pupal mortality was recorded from the experimental pupae treated with 50,75 and 100 ppm concentration of extracts. Three fractions have been tested for their larvicidal activity of which the Fraction 3 showed the LC50 and LC90 values of 23.23 and 40.39 ppm.With regard to the ovicidal effect fraction 3 showed highest ovicidal activities than the other two fractions.Furthermore,there were no hatchabilily was recorded above 50 ppm(100%egg mortality) in the experimental group.Statistically significant pupicidal activity was recorded from 75 ppm concentration.Conclusions:From the results it can be concluded the crude extract of G.sepium is an excellent potential for controlling An.stephensi mosquito.It is apparent that,iraction 3 possess a novel and active principle which could be responsible for those biological activities. | Kaliyamoorthy Krishnappa Shanmugam Dhanasekaran Kuppusamy Elumalai | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 2 |
| 6 | Experimental investigation and ANN modeling on improved performance of an innovative method of using heave response of a non-floating object for ocean wave energy conversion显示文摘 | Srinivasan CHANDRASEKARAN Arunachalam AMARKARTHIK Karuppan SIVAKUMAR Dhanasekaran SELVAMUTHUKUMARAN Shaji SIDNEY | 2013 | Frontiers in Energy2013，7，3： | 2 |
| 7 | Amyloidbeta peptides and glutamatergic synaptic dysregulation显示文摘 | Parameshwaran K Dhanasekaran M Suppiramaniam V | 2008 | ExpNeurol2008，210，1： | 1 |
| 8 | Hepatocellular carcinoma: Current trends in worldwide epidemiology,risk factors, diagnosis, and therapeutics显示文摘 | Dhanasekaran R Limaye A Cabrera R | 2012 | Hepat Med2012，4，： | 1 |
| 9 | Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics显示文摘 | DHANASEKARAN R LIMAYE A CABRERA R | 2012 | Hepat Med2012，4，： | 1 |
| 10 | Treatment outcomes and prognostic factors of intrahepatic cholang- iocarcinoma 显示文摘 | Dhanasekaran R Hemming AW Zendejas I | 2013 | Oncol Rep2013，29，4： | 1 |
| 11 | FIZZ1 stimulation of myofibroblast differentiation显示文摘 | LIU T DHANASEKARAN S M JIN H | 2004 | Am J Pathol2004，164，4： | 1 |
| 12 | Lipid binding induced conformational change in human apolipopotein E:evidence for tow lipid-bound sates on spherical particles显示文摘 | Saito H Dhanasekaran P Baldwin F | 2001 | J Biol Chem2001，276，40： | 1 |
| 13 | Delineation of prognostic biomarkers in prostate cancer显示文摘 | Dhanasekaran SM Barrette TR Ghosh D | | 0，，6849： | 1 |
| 14 | Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation显示文摘The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells(ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as 'guardians', controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation. | Siddharth Narayanan Gopalakrishnan Loganathan Maheswaran Dhanasekaran William Tucker Ankit Patel Venugopal Subhashree SriPrakash Mokshagundam Michael G Hughes Stuart K Williams Appakalai N Balamurugan | 2017 | World Journal of Transplantation2017，7，2： | 1 |
| 15 | The polycomb group protein EZH2 is involved in progression of prostate cancer显示文摘 | Varambally S Dhanasekaran SM Zhou M | 2002 | Nature2002，419，6907： | 1 |
| 16 | Multifunc- tional human transcriptional coactivato-r protein PC4 is a substrate of Aurora kinases and activates the Aurora en- zymes显示文摘 | Dhanasekaran K Kumari S Boopathi R | 2016 | FEBS J2016，283，6： | 1 |
| 17 | Acute respiratory and systemic toxicity of pulmo nary exposure to rutile Fe-doped TiO2 nanorods显示文摘 | Nemmar A Melghit K AI-Salam S Zia S Dhanasekaran S At toub S et aI | 2011 | Toxicolo gy2011，279，13： | 1 |
| 18 | Neuroprotective effects of theantiParkinson drug Mucuna pruriens显示文摘 | Manyam BV Dhanasekaran M Hare TA | 2004 | Phytother Res2004，18，： | 1 |
| 19 | The polycomb group protein EZH2 is involved in progression of prostate cancer 显示文摘 | Varambally S Dhanasekaran SM Zhou M | 2002 | Nature2002，419，6907： | 1 |
| 20 | JNK signaling in apoptosis 显示文摘 | Dhanasekaran DN Reddy EP | 2008 | Oncogene2008，27，： | 1 |
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