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| 1 | EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer 显示文摘 | Haslehurst AM Koti M Dharsee M | 2012 | BMC Cancer2012，12，： | 1 |
| 2 | EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer显示文摘 | Haslehurst AM Koti M Dharsee M | 2012 | BMC Cancer2012，12，： | 1 |
| 3 | EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer显示文摘 | Haslehurst AM Koti M Dharsee M | 2012 | BMC Cancer2012，12，1： | 1 |
| 4 | EMT transcription fac- tors snail and slug directly contribute to cisplatin resistance in ovari- an cancer显示文摘 | Haslehurst AM Koti M Dharsee M | 2012 | BMC Cancer2012，12，： | 1 |
| 5 | EMT transcription fac- tors snail and slug directly contribute to cisplatin resistance in ovari- an cancer显示文摘 | Haslehurst AM Koti M Dharsee M | 2012 | BMC Cancer2012，12，： | 1 |
| 6 | EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer显示文摘 | Haslehurst AM Koti M Dharsee M | | 0，，01： | 1 |
| 7 | EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer显示文摘 | Haslehurst AM Koti M Dharsee M | | 0，，01： | 1 |
| 8 | EMT tran- scription factors snail and slug directly contribute to cis- platin resistance in ovarian cancer 显示文摘 | Haslehurst AM Koti M Dharsee M | 2012 | BMC Cancer2012，12，： | 1 |
| 9 | Increasing Deaths Due to Malignancy in HIV+ Patients is Associated with Integrase Inhibitor Therapy显示文摘Despite reductions in AIDS-related deaths, registries show HIV+ patients are still dying at a younger age than HIV-peers. Although overall mortality has declined in this population, a growing percent of deaths are due to malignancy. Since the data demonstrating the growing percentage of deaths due to malignancy in the HIV+ population is derived from registries, the study explores whether the subset dying from malignancy has particular characteristics that can be seen in a well-characterized cohort. In the well-characterized HIV+ cohort, the percentage of deaths due to cancer was seen to increase over four years (2010-2013) from 21% to 24% to 38% to 40%. The mean CD4-count of those who died from malignancy was 252+/-42 and 333+/-36 in patients with death from other causes. The viral load was not suppressed in 26% of patients dying from malignancy. Of patients on integrase inhibitor therapy, 48% of deaths were due to malignancy while in patients not on this therapy, 10% of deaths were due to malignancy (relative risk = 4.8). In HIV+ patients, a low CD4-count, failure to achieve viral suppression, and use of integrase inhibitors were associated with malignancy as the cause of death. The association of a specific therapy, integrase inhibition, with malignancy is seen in the study. | Daniel O. Griffin Arif Dharsee Juan Carlos Rico Joseph McGowan | 2014 | Journal of Health Science2014，2，5： | 0 |
| 10 | HLA-G and single nucleotide polymorphism(SNP)associations with cancer in African populations:Implications in personal medicine显示文摘The immune system plays an important role in protecting the body against malignancy.During cancer immunoediting,the immune system can recognize and keep checking the tumor cells by down-expression of some self-molecules or by increasing expression of some novel molecules.However,the microenvironment created in the course of cancer development hampers the immune ability to recognize and destroy the transforming cells.Human Leukocyte Antigen G(HLA-G)is emerging as immune checkpoint molecule produced more by cancer cells to weaken the immune response against them.HLA-G is a non-classical HLA class I molecule which is normally expressed in immune privileged tissues as a soluble or membrane-bound protein.HLA-G locus is highly polymorphic in the non-coding 3′untranslated region(UTR)and in the 5′upstream regulatory region(5′URR).HLA-G expression is controlled by polymorphisms located in these regions,and several association studies between these polymorphic sites and disease predisposition,response to therapy,and/or HLA-G protein expression have been reported.Various polymorphisms are demonstrated to modulate its expression and this is increasingly finding more significance in cancer biology.This review focuses on the relevance of the HLA-G gene and its polymorphisms in cancer development.We highlight population genetics of HLA-G as evidence to espouse the need and importance of exploring potential utility of HLA-G in cancer diagnosis,prognosis and immunotherapy in the currently understudied African population. | Ismael Chatita Adolf Amany Almars Nazima Dharsee Teddy Mselle Gokce Akan Irene Jeremiah Nguma Abdolrahman S.Nateri Fatmahan Atalar | 2022 | Genes & Diseases2022，9，5： | 0 |
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