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| 1 | Residual renal function in peritoneal dialysis with failed allograft and minimum immunosuppression显示文摘Immunosuppression(IS) is often withdrawn in patients with end stage renal disease secondary to a failed renal allograft, and this can lead to an accelerated loss of residual renal function(RRF). As maintenance of RRF appears to provide a survival benefit to peritoneal dialysis(PD) patients, it is not clear whether this benefit of maintaining RRF in failed allograft patients returning to PD outweigh the risks of maintaining IS. A 49 year-old Caucasian male developed progressive allograft failure nine years after living-donor renal transplantation. Hemodialysis was initiated via tunneled dialysis catheter(TDC) and IS was gradually withdrawn. Two weeksafter IS withdrawal he developed a febrile illness, which necessitate removal of the TDC and conversion to PD. He was maintained on small dose of tacrolimus(1 mg/d) and prednisone(5 mg/d). Currently(1 year later) he is doing exceedingly well on cycler-assisted PD. Residual urine output ranges between 600-1200 m L/d. Total weekly Kt/V achieved 1.82. RRF remained well preserved in this patient with failed renal allograft with minimal immunosuppressive therapy. This strategy will need further study in well-defined cohorts of PD patients with failed allografts and residual RRF to determine efficacy and safety. | Nadear Elmahi éva Csongrádi Kenneth Kokko Jack R Lewin Jamie Davison Tibor Fülp | 2013 | World Journal of Transplantation2013，3，2： | 5 |
| 2 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 3 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 4 | Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1beta显示文摘 | Lebovic DI Bentzien F Chao VA | 2000 | Mol Hum Reprod2000，6，3： | 1 |
| 5 | TFEB links autophagy to lysosomal biogenesis 显示文摘 | Settembre C Di Malta C Polito VA | 2011 | Science2011，332，6036： | 1 |
| 6 | IL-1beta induction of RANTES (regulated upon activation,normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappaB site in the proximal promoter显示文摘 | Lebovic DI Chao VA Martini JF | 2001 | J Clin Endocrinol Metab2001，86，10： | 1 |
| 7 | Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1beta显示文摘 | Lebovic DI Bentzien F Chao VA | 2000 | Mol Hum Reprod2000，6，3： | 1 |
| 8 | Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1 beta显示文摘 | Lebovic DI Bentzien F Chao VA | 2000 | Mol Hum Reprod2000，6，3： | 1 |
| 9 | Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor显示文摘 | Di Croce L Raker VA Corsaro M | 2002 | Science2002，295，5557： | 1 |
| 10 | New direct and indirect methods for the detection of cyclooxygenase 1 acetylation by aspirin; the lack of aspirin resistance among healthy individuals显示文摘 | Emese G. Kovács éva Katona Zsuzsanna Bereczky Nóra Homoródi László Balogh Eszter Tóth Hajna Péterfy Róbert G. Kiss István édes László Muszbek | 2012 | Thrombosis Research2012，，： | 1 |
| 11 | Assessment of inflammatory activity in Crohn's disease by means of dynamic contrast - enhanced MRI 显示文摘 | Pupillo VA Di Cesare E Frieri G | 2007 | Radiol Med(Torino)2007，112，6： | 1 |
| 12 | p16 (INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma显示文摘 | Di VA Perdelli L Banelli B | 2005 | Int J Cancer2005，114，3： | 1 |
| 13 | IL-lbeta induction of RANTES(regulated upon activation,normal T cell expressed and secreted)chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kB site in the proximal promoter显示文摘 | Lebrovic DI Chao VA Taylor RN | 2001 | J Clin Endocrinol Metab2001，86，10： | 1 |
| 14 | Induction of an angio-genic phenotype in endometriotic stromal cell cultures by interleukin-1 beta显示文摘 | Lebovic DI Bentzien F Chao VA | 2000 | Mol Hum Reprod2000，6，3： | 1 |
| 15 | Pathological and molecular characteristics distinguishing contralateral metastatic from new primary breast cancer显示文摘 | Banelli B Casciano I Di VA | 2010 | Ann Oncol2010，21，6： | 1 |
| 16 | Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor显示文摘 | Di Croce L Raker VA Corsaro M | 2002 | Science2002，295，5557： | 1 |
| 17 | Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor显示文摘 | Di Croce L Raker VA Corsaro M | 2002 | Science2002，295，5557： | 1 |
| 18 | Methyltransferase recruitment and DNA hypermethyiation of target promoters by an oncogenic transcription factor 显示文摘 | DI Croce I Raker VA Corsaro M | 2002 | Science2002，295，5557： | 1 |
| 19 | Peritoneal macrophages induce RANTES (regulated on activation,normal T cell expressed and secreted)chemokine gene transcription in endometrial stromal cells显示文摘 | Lebrovic DI Chao VA Taylor RN | 2004 | J Clin Endocrinol Metab2004，89，3： | 1 |
| 20 | p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma 显示文摘 | Di VA Perdelli L Banelli B | 2005 | Int J Cancer2005，114，3： | 1 |
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