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| 1 | 土霉素对柑橘黄龙病的防治效果及对柑橘产量和品质的影响显示文摘为有效防控柑橘黄龙病,于2017年在佛罗里达大学柑橘研究与教育中心的奥本代尔市柑橘试验场进行田间试验筛选黄龙病的防治药剂及其浓度,测定注射土霉素后叶片中柑橘黄龙病菌亚洲种Cadidatus Liberibacter asiaticus、土霉素、淀粉含量、柑橘产量、出汁率、可溶性固形物含量和酸度,显微镜下观察注射土霉素后淀粉粒的分布。结果表明,浓度为1.6 g/株土霉素处理180 d后柑橘叶片中黄龙病菌亚洲种含量减少幅度最大,为91.78%;注射浓度为1.6 g/株土霉素后7 d,叶片中土霉素含量达142.2μg/kg,注射后11 d叶片中土霉素含量达到最大,为239.8μg/kg,注射后45 d叶片中土霉素含量低至99.6μg/kg以下;注射后7~90 d,叶片中黄龙病菌亚洲种含量呈波浪形变化,注射90 d后叶片中黄龙病菌亚洲种含量一直处于增长趋势,叶片中黄龙病菌亚洲种含量总体随着土霉素含量的升高而降低;注射浓度为1.6 g/株土霉素后,叶片中淀粉含量大幅度下降,60 d时达到最低值,为3.3μg/mm2,90 d时达到峰值,为14.5μg/mm2;单株产量为16.7 kg,与注射浓度为0.8 g/株土霉素处理差异不显著,但均显著高于其它2个处理;柑橘出汁率、可溶性固形物和酸度均与清水对照差异不显著。表明土霉素可有效抑制黄龙病菌亚洲种,减少柑橘叶片内淀粉含量,增加柑橘产量,但对果实品质未产生显著影响。 | 姚廷山 周彦 ACHOR Diann LI Jinyun WANG Nian 周常勇 | 2020 | 植物保护学报2020，47，6： | 6 |
| 2 | 走向可持续山地社区:在加拿大班夫和班夫国家公园保持旅游开发和环境保护平衡显示文摘尽管发展中国家对成熟山地旅游社区的研究比较普遍,但加拿大班夫在发展基于社区的可持续山地旅游业方面的原则和实践会给国际社会提供可能有用的经验。因此,本文集中论述了《班夫社区计划》,目的是强调可持续山地旅游业管理问题中的'班夫'解决方案。由于班夫和班夫国家公园115年复杂的历史联系,因此它在保持山地旅游开发和环境保护平衡上的方法可能是独特的。尽管如此,该镇为成为一个平衡的可持续国家公园社区,正在使用一些创新的原则如'不要负面环境影响'和'适度开发利用'原则。这些原则有助于《21世纪议程》第13章(《山地议程》)的实施,并会在实现可持续社区过程中促进管理问题的解决。 | Dianne Draper 高启晨 | 2000 | AMBIO-人类环境杂志2000，29，7： | 6 |
| 3 | s Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?显示文摘Background: Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia. Methods: In total, 547 out-patients aged 18-5 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4^th Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator. Results: Early-onset MDD (EOD, 〈30 years) was associated with longer illness (P - 0.003), unmarried status (P 〈 0.001), higher neuroticism (P 〈 0.002) based on the SCL-90-R, and more limited social function and mental health (P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients with younger onset ages. Special clinical features and more impaired social function and quality of life were associated with EOD, as in western studies. Conclusions: EOD often follows higher levels of neuroticism. Age of onset of MDD may be a predictor of clinical features and impaired social function, allowing earlier diagnosis and treatment. | Yan-Hong Liu Lin Chen Yun-Ai Su Yi-Ru Fang Manit Srisurapanont Jin Pyo Hong Ahmad Hatim Hong Choon Chua Dianne Bautista Tian-Mei Si | 2015 | Chinese Medical Journal2015，，6： | 5 |
| 4 | Effects of luteinizing hormone and androgen on the development of rat progenitor Leydig cells in vitro and in vivo显示文摘祖先 Leydig 房间从干细胞被导出。祖先 Leydig 房间的增长和区别显著地在发身期间贡献 Leydig 房间数字。然而,这些过程的规定仍然保持不清楚。现在的学习的目的是决定 luteinizing 荷尔蒙(LH ) 或雄激素是否贡献祖先 Leydig 房间的增长和区别。Fourteen-day-old 男 Sprague-Dawley 老鼠与 NalGlu 被对待 7 天,它是一个释放 gonadotropin 荷尔蒙对手,到在垂体并且这样减少 LH 的分泌物,在睾丸的雄激素。老鼠与 LH 或 7 α 被共同管理; -methyl-nortestosterone (MENT ) 是对由 5 α 的新陈代谢抵抗的雄激素, -reductase 1 在祖先 Leydig 房间,和 LH 或雄激素的随后的效果被测量。3 H-Thymidine 静脉内地也被注入老鼠在祖先 Leydig 房间学习 thymidine 加入。祖先 Leydig 房间被检验。NalGlu 管理由 83 % 减少了祖先 Leydig 房间增长;。另外, LH 或 MENT 处理恢复了 Leydig 房间 proliferative 能力到 73 %或 50 %控制,分别地。增长相关的基因的送信人 RNA 层次用即时 PCR 被测量。Igf1, Lifr, Pdgfra, Bcl2, Ccnd3 和 Pcna 的表示层次是由 MENT 的 upregulated,并且 Pdgfra, Ccnd3 和 Pcna 的那些是由 LH 的 upregulated。LH 和 MENT 在 vitro 刺激了祖先 Leydig 房间的区别。我们断定 LH 和 MENT 涉及调整祖先 Leydig 房间的发展。 | Jing-Jing Guo Xue Ma Claire Q F Wang Yu-Fei Ge Qing-Quan Lian Dianne O Hard Yu-Fei Zhang Qiang Dong Yun-Fei Xu Ren-Shan Ge | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 5 | Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter显示文摘肾调整雄激素的蛋白质(Kap ) 基因是由雄激素在老鼠肾特定、调整的织物近似小管房间(PTC ) 。在现在的学习,我们试图识别最小的 PTC 特定的调整雄激素的 Kap 倡导者并且分析它的雄激素反应元素(AREs ) 。Kap1542 倡导者 / 酶构造的一个删除系列是 assayed 在里面鼠肾(好) PTC 当面或 15 nM dihydrotestosterone (DHT ) 的缺席。Kap1542 和 Kap637 举办了低活动和没有雄激素正式就职;Kap224 举办了比 Kap1542 的高是到 5 褶层的 4- 的一项基础活动,但是被 DHT 仅仅稍微导致。Kap147 举办了比 Kap1542 的高是到 3 褶层的 2- 并且被 DHT 4- 导致到 6 褶层的一项基础活动。Kap77 废除了基础倡导者活动,但是被 DHT 仍然导致。结果证明在 vitro, Kap147 是一个最小的调整雄激素的倡导者。在不同房间的短暂 transfection 证明 Kap147 明确地在 PTC 开始了记者基因表示。顺序分析揭示了在位置 −124 和 Kap147 的 −39 定位的二潜在的 AREs。Mutational 试金证明仅仅在 −124 的 ARE 在好房间涉及雄激素反应。Electrophoretic 活动性移动试金也证实 −124 雄激素受体明确地一定。在结论,我们定义可以是为肾的学习的一个好模型的最小的 Kap147 倡导者在 vivo 导致一只雄激素特定的应答的海角的 PTC 特定的表示和分子的机制。 | Liqiang Fan Dianne O Hardy James F Catteral Jian Zhao Suxia Li | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 4 |
| 6 | Breast cancer in China显示文摘 | Lei Fan Kathrin Strasser-Weippl Jun-Jie Li Jessica St Louis Dianne M Finkelstein Ke-Da Yu Wan-Qing Chen Zhi-Ming Shao Paul E Goss | 2014 | Lancet Oncology2014，，7： | 4 |
| 7 | 土霉素处理对Valencia夏橙中淀粉及相关基因表达的影响显示文摘黄龙病(Huanglongbing,HLB)会造成柑橘韧皮部坏死堵塞,导致光合同化物运输不畅,淀粉大量积累。在感染HLB的4年生Valencia夏橙病株上分别注入0.1和0.2 g·株^(-1)土霉素(Oxytetracycline,OTC),90 d后运用qPCR检测,病株中HLB病原菌(Candidatus Liberibacter asiaticus,Las)含量均明显降低,且0.2和0.1 g·株^(-1) OTC处理的效果相当。I2/KI显色及LM观测表明,0.2 g·株^(-1) OTC处理后植株的淀粉含量从注射前的18.58μg·mm^(-2)减少至90 d的5.24μg·mm^(-2),而0.1 g·株^(-1)的处理90 d仅降至11.88μg·mm^(-2)。高效液相色谱(HPLC)检测结果表明,注射后90 d内,试验用浓度0.2 g·株^(-1) OTC在植株体内可降解至200μg·kg^(-1)以下。基因表达结果表明,注射0.2 g·株^(-1) OTC后30和90 d,淀粉合成及分解相关基因表达量均下降,其中淀粉合成相关基因AGPase表达量下降最显著,这与OTC注射后30和90 d叶片内淀粉含量下降结果一致。 | 姚廷山 周彦 Diann Achor 周常勇 | 2019 | 园艺学报2019，46，2： | 3 |
| 8 | Asymmetry in the Assembly of the RNAi Enzyme Complex显示文摘 | Dianne S. Schwarz Gy?rgy Hutvágner Tingting Du Zuoshang Xu Neil Aronin Phillip D. Zamore | 2003 | Cell2003，，2： | 3 |
| 9 | Tracking domestic ducks:A novel approach for documenting poultry market chains in the context of avian influenza transmission显示文摘Agro-ecological conditions associated with the spread and persistence of highly pathogenic avian influenza(HPAI) are not well understood, but the trade of live poultry is suspected to be a major pathway. Although market chains of live bird trade have been studied through indirect means including interviews and questionnaires, direct methods have not been used to identify movements of individual poultry. To bridge the knowledge gap on quantitative movement and transportation of poultry, we introduced a novel approach for applying telemetry to document domestic duck movements from source farms at Poyang Lake, China. We deployed recently developed transmitters that record Global Positioning System(GPS) locations and send them through the Groupe Spécial Mobile(GSM) cellular telephone system. For the first time, we were able to track individually marked ducks from 3 to 396 km from their origin to other farms, distribution facilities, or live bird markets. Our proof of concept test showed that the use of GPS-GSM transmitters may provide direct, quantitative information to document the movement of poultry and reveal their market chains. Our findings provide an initial indication of the complexity of source-market network connectivity and highlight the great potential for futuretelemetry studies in poultry network analyses. | Chang-Yong Choi John Y Takekawa XIONG Yue LIU Ying Martin Wikelski George Heine Diann J Prosser Scott H Newman John Edwards Fusheng Guo Xiangming Xiao | 2016 | Journal of Integrative Agriculture2016，15，7： | 3 |
| 10 | 土霉素处理对柑橘黄龙病的防治效果及PP2基因表达的影响显示文摘【目的】评价土霉素(oxytetracycline,OTC)药剂对不同发病程度柑橘黄龙病(Huanglongbing,HLB)的防治效果,并检测OTC处理后韧皮部关键基因——韧皮部蛋白2(PP2)的表达量变化,为HLB的有效防控提供科学依据,也为OTC作用机理研究提供参考。【方法】应用可有效抑制、杀死病原菌的OTC,树干定量注射0.1 g/树于不同发病程度HLB(初感染、轻度发病和重度发病3组)的4年生Valencia夏橙,注射后7、30、60、90 d定期采集Valencia叶片样品监测HLB致病菌Cadidatus Liberibacter asiaticus(Las)含量、淀粉含量及PP2基因表达量变化。树干注射OTC后90 d采集不同处理Valencia的嫩叶、成熟叶片及茎,进行淀粉染色光学显微观察(LM),直观反映植株累积淀粉的变化。树干注射OTC后80 d调查柑橘嫩叶抽发的情况,综合一系列指标评价OTC对HLB的防治效果。【结果】注射OTC 0.1 g/树对初感染HLB的4年生Valencia植株治疗作用最明显,7 d后检测即为阴性,并可保持90 d,其成熟叶片的淀粉含量明显减少,但茎内仍有淀粉粒富集;轻度发病夏橙注射90 d后叶片内的Las含量从(1.68×10~6±858884)cells/g叶片减至(7.21×10~4±30981)cells/g叶片,下降幅度极为明显,其成熟叶片内的淀粉含量在90 d内一直呈下降趋势;重度发病植株注射后叶片内的Las含量从(4.10×108±3.04×10~8)cells/g叶片减至(2.80×10~7±2.70×10~7)cells/g叶片,但从数量而言仍然有较多分布,除了新长出的秋梢,其成熟叶及茎内的淀粉粒含量仍旧很大,说明0.1 g/株OTC不足以治愈4年生重度发病Valencia夏橙。对PP2基因表达分析结果显示,注射OTC后30 d,Valencia夏橙体内的PP2基因表达量大幅度下降,随后90 d内表达量稳定,与注射后30 d的表达量较为一致。【结论】OTC可以用于HLB的防控,对初感染(Las含量为<9.00×10~5 cells/g叶片)及轻度发病(Las含量为9.00×10~5—9.00×10~7 cells/g叶片)的柑橘植株治疗作用较好,不适用于重度发病植株(Las含量为>9.00×10~7 cells/g叶片)的治疗。注射OTC后,PP2基因表达量下降明显,说明OTC可有效减少韧皮部病菌等的胁迫压力。 | 姚廷山 周彦 DIANN ACHOR 王年 周常勇 | 2019 | 中国农业科学2019，0，7： | 3 |
| 11 | 食物蛋白诱导性小肠结肠炎综合征:一项基于澳大利
亚普通人群的研究,2012-2014显示文摘背景 食物蛋白诱导性小肠结肠炎综合征(FPIES)是一种非IgE 介导的胃肠道过敏性疾病。基于大规模人群的FPIES 流行病学调查尚无报道。目的 本文拟明确澳大利亚婴幼儿中FPIES 的发病率和临床特点。方法 2012 至2014年通过澳大利亚儿科监测体系开展了一项全国范围内的调查,由1 400 名儿科医生每月上报2 岁以下的婴幼儿中诊为急性FPIES 的新病例。结果 230 例患儿被诊为FPIES。FPIES 在澳大利亚2 岁以下儿童中的发病率为15.4/(10 万·年)。首次发作、诊断及上报的中位数年龄分别为5、7 和10 月龄。发病没有性别倾向性。7% 的患儿有兄弟姐妹也患有FPIES,5% 在纯母乳喂养期间发病。68 例患儿仅对单种食物过敏(20% 对2 种食物过敏,12% 对3 种以上食物过敏)。最常见的FPIES 诱因是大米(45%)、牛奶(33%)以及鸡蛋(12%)。51% 的患儿在首次暴露时即有过敏反应。与单种食物过敏相比,多种食物过敏者的首次发病年龄更小(均数分别为4.6 和5.8 月龄,P = 0.001),更容易有水果或蔬菜过敏(P < 0.000 1)。纯母乳喂养4 个月以上的婴儿更不易发生多种食物过敏性FPIES(P = 0.06)。对包括牛奶在内的多种食物过敏的FPIES 患儿中64% 同时对固体食物过敏。42% 鱼类过敏性FPIES 患儿并发其他食物过敏。结论 FPIES并不罕见,估计发病率为15.4/(10 万·年)。大米是澳大利亚最常见的食物诱因。与多重食物过敏性FPIES 相关的危
险因素包括早期起病、对水果或蔬菜不能耐受。 | Sam Mehr FRACP, Katie Frith FRACP Elizabeth H. Barnes BAppSc MStat and Dianne E Campbell | 2018 | 中华临床免疫和变态反应杂志2018，12，1： | 2 |
| 12 | 食物过敏治疗显示文摘IgE 介导的食物过敏患病率在全世界范围内呈升高趋势,已成为困扰数以百万计患者的公共健康问题。但目前的标准治疗方案仅为严格禁食过敏食物及含过敏食物成分的食品,尚无已经审批认证的食物过敏治疗方法。目前已有大量的有关不同形式食物免疫治疗的研究,包括口服、舌下及经皮给药途径。尽管口服免疫治疗因蛋白摄入量最大而疗效最肯定,但与舌下免疫治疗及经皮免疫治疗相比耐受性较差,不良反应重,发生率也较高。经皮免疫治疗虽然疗效相对最弱,但安全性及耐受性最佳。很多研究通过尝试添加佐剂和anti-IgE 提高食物免疫治疗的疗效及安全性。此外还有许多超前于这些第一代食物免疫治疗方法的新概念疗法尚处于动物试验或早期I 期临床试验阶段。 | Sam Mehr Katie Frith Elizabeth H.Barnes BAppSc MStat Dianne E.Campbell 王子熹 王良录 | 2018 | 中华临床免疫和变态反应杂志2018，12，1： | 2 |
| 13 | Model for end-stage liver disease and Child-Turcotte-Pugh score as predictors of pretransplantation disease severity, posttransplantation outcome, and resource utilization in United Network for Organ Sharing status 2A patients显示文摘 | Robert S. Brown K.Shiva Kumar Mark W. Russo Milan Kinkhabwala Dianne L. Rudow Patricia Harren Steven Lobritto Jean C. Emond | 2002 | Liver Transplantation2002，，3： | 2 |
| 14 | Regional landslide-hazard assessment for Seattle, Washington, USA显示文摘 | Rex L. Baum Jeffery A. Coe Jonathan W. Godt Edwin L. Harp Mark E. Reid William Z. Savage William H. Schulz Dianne L. Brien Alan F. Chleborad Jonathan P. McKenna John A. Michael | 2005 | Landslides2005，，4： | 2 |
| 15 | The combination of explicit and implicit learning processes in task control显示文摘 | Dianne C. Berry Donald E. Broadbent | 1987 | Psychological Research1987，，1： | 2 |
| 16 | Mucin-Producing Neoplasms of the Pancreas: An Analysis of Distinguishing Clinical and Epidemiologic Characteristics显示文摘 | Stefano Crippa Carlos Fernández–del Castillo Roberto Salvia Dianne Finkelstein Claudio Bassi Ismael Domínguez Alona Muzikansky Sarah P. Thayer Massimo Falconi Mari Mino–Kenudson Paola Capelli Gregory Y. Lauwers Stefano Partelli Paolo Pederzoli Andrew L. W | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 2 |
| 17 | Blue sheep in the Annapurna Conservation Area,Nepal:habitat use,population biomass and their contribution to the carrying capacity of snow leopards显示文摘The Himalaya region of Nepal provides a habitat for the endangered snow leopard(Panthera uncia)and its principal prey species,the blue sheep(Pseudois nayaur).The aim of this study was to describe the habitat,the distribution and the population structure of blue sheep,and to estimate their contribution to the carrying capac-ity of snow leopard in the upper Mustang region of Nepal.Blue sheep were recorded at altitudes from 3209-5498 m on slopes with gradients of 16-60°and aspects of 40°NE to 140°SE.A total of 939 blue sheep were counted in the upper Mustang region,and 98 were counted in the Yak Kharka region of Manang district;how-ever,upper Mustang had the lowest population density of blue sheep recorded within their distribution range in Nepal(0.86 blue sheep/km^(2)).The results of the study show that a higher density of blue sheep is associated with greater plant species diversity.The most important species present in the blue sheep habitat were Kobresia pyg-maea,Artemesia spp.,Lonicera spp.,Lancea tibetica,Poa spp.,Astragalus spp.and Ephedra gerardiana.It is estimated that the existing blue sheep population biomass of approximately 38925 kg in the upper Mustang re-gion could support approximately 19 snow leopards(1.6 snow leopards/100 km^(2)). | Achyut ARYAL Dianne BRUNTON Weihong JI David RAUBENHEIMER | 2014 | Integrative Zoology2014，9，1： | 2 |
| 18 | Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4显示文摘 | Dianne H. Dapito Ali Mencin Geum-Youn Gwak Jean-Philippe Pradere Myoung-Kuk Jang Ingmar Mederacke Jorge M. Caviglia Hossein Khiabanian Adebowale Adeyemi Ramon Bataller Jay H. Lefkowitch Maureen Bower Richard Friedman R. Balfour Sartor Raul Rabadan Robert | 2012 | Cancer Cell2012，，4： | 2 |
| 19 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance显示文摘 | Christopher B. Newgard Jie An James R. Bain Michael J. Muehlbauer Robert D. Stevens Lillian F. Lien Andrea M. Haqq Svati H. Shah Michelle Arlotto Cris A. Slentz James Rochon Dianne Gallup Olga Ilkayeva Brett R. Wenner William S. Yancy Howard Eisenson Gera | 2009 | Cell Metabolism2009，，4： | 2 |
| 20 | Frequency filtering of vestibular signals by synaptic transmission inbrainstem slices显示文摘 | Dianne MB Allison LG | 2007 | BMC Neuroscience2007，8，： | 1 |
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