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| 1 | Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up显示文摘AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal. | Renato Caviglia Mentore Ribolsi Marina Rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala | 2007 | World Journal of Gastroenterology2007，13，39： | 14 |
| 2 | Comparative outcome of stapled trans-anal rectal resection and macrogol in the treatment of defecation disorders显示文摘AIM:To prospectively assess the eff icacy and safety of stapled trans-anal rectal resection(STARR) compared to standard conservative treatment,and whether preoperative symptoms and findings at defecography and anorectal manometry can predict the outcome of STARR.METHODS:Thirty patients(Female,28;age:51 ± 9 years) with rectocele or rectal intussusception,a defecation disorder,and functional constipation were submitted for STARR.Thirty comparable patients(Female,30;age 53 ± 13 years),who presented with symptoms of rectocele or rectal intussusception and were treated with macrogol,were assessed.Patients were interviewed with a standardized questionnaire at study enrollment and 38 ± 18 mo after the STARR procedure or during macrogol treatment.A responder was def ined as an absence of the Rome Ⅲ diagnostic criteria for functional constipation.Defecography and rectoanal manometry were performed before and after the STARR procedure in 16 and 12 patients,respectively.RESULTS:After STARR,53% of patients were responders;during conservative treatment,75% were responders.After STARR,30% of the patients reported the use of laxatives,17% had intermittent anal pain,13% had anal leakage,13% required digital facilitation,6% experienced defecatory urgency,6% experienced fecal incontinence,and 6% required re-intervention.During macrogol therapy,23% of the patients complained of abdominal bloating and 13% of borborygmi,and 3% required digital facilitation.No preoperative symptom,defecographic,or manometric finding predicted the outcome of STARR.Post-operative defecography showed a statistically significant reduction(P < 0.05) of the rectal diameter and rectocele.The postoperative anorectal manometry showed that anal pressure and rectal sensitivity were not significantly modified,and that rectal compliance was reduced(P = 0.01).CONCLUSION:STARR is not better and is less safe than macrogol in the treatment of defecation disorders.It could be considered as an alternative therapy in patients unresponsive to macrogol. | Ivano Biviano Danilo Badiali Laura Candeloro Fortunée Irene Irene Habib Massimo Mongardini Angelo Caviglia Fiorella Anzini Enrico S Corazziari | 2011 | World Journal of Gastroenterology2011，17，37： | 3 |
| 3 | Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014显示文摘AIM To assess the etiology of chronic liver diseases(CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology.METHODS A random sample of charts of patients referred to for increased liver enzymes between January 1998 and December 2006, and between January 2012 and December 2014 were reviewed. Etiology search included testing for hepatitis B virus(HBV), hepatitis C virus(HCV), autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease and hereditary hemocromatosis. A risky alcohol consumption was also considered. Nonalcoholic fatty liver disease(NAFLD) was diagnosed in patients with histological and/or ultrasound evidence of steatosis/steatohepatitis, and without other causes of CLD.RESULTS The number of patients included was 1163. Of them, 528(45%) had positivity for HCV and 85(7%) for HBV. Among the virus-free patients, 417(36%) had metabolic disorders whereas the remaining had history of alcohol abuse, less prevalent causes of CLD or concomitant conditions. In comparison to 1998-2000(41%), a reduction of HCV alone-related cases was detected during the periods 2001-2003(35%, OR = 0.75, 95%CI: 0.53-1.06), 2004-2006(33%, OR = 0.70, 95%CI: 0.50-0.97) and 2012-2014(31%, OR = 0.64, 95%CI: 0.46-0.91). On the contrary, in comparison to 1998-2000(31%), metabolic-alone disorders increased in the period 2004-2006(39%, OR = 1.37, 95%CI: 0.99-1.91) and 2012-2014(41%, OR = 1.53, 95%CI: 1.09-2.16). The other etiologies remained stable. The increase of incidence of metabolic-alone etiology during the period 2004-2006 and 2012-2014 tended to be higher in older patients(≥ 50 years) compared to younger(P = 0.058).CONCLUSION In the Northwest of Italy, during this study period, the prevalence of HCV infection decreased notably whereas that of NAFLD increased. | Giorgio Maria Saracco Andrea Evangelista Sharmila Fagoonee Giovannino Ciccone Elisabetta Bugianesi Gian Paolo Caviglia Maria Lorena Abate Mario Rizzetto Rinaldo Pellicano Antonina Smedile | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 4 | Tailored prolapse surgery for the treatment of haemorrhoids and obstructed defecation syndrome with a new dedicated device: TST STARR Plus显示文摘 | Gabriele Naldini Jacopo Martellucci Roberto Rea Stefano Lucchini Michele Schiano di Visconte Angelo Caviglia Claudia Menconi Donglin Ren Ping He Domenico Mascagni | 2014 | International Journal of Colorectal Disease2014，，5： | 2 |
| 5 | Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4显示文摘 | Dianne H. Dapito Ali Mencin Geum-Youn Gwak Jean-Philippe Pradere Myoung-Kuk Jang Ingmar Mederacke Jorge M. Caviglia Hossein Khiabanian Adebowale Adeyemi Ramon Bataller Jay H. Lefkowitch Maureen Bower Richard Friedman R. Balfour Sartor Raul Rabadan Robert | 2012 | Cancer Cell2012，，4： | 2 |
| 6 | Bonding of silicon wafers for silicon on insulator 显示文摘 | MASZARA W P GOETZ G CAVIGLIA A | 1988 | Appl Phys1988，64，15： | 1 |
| 7 | Outcome of chronic delta hepatitis in Italy: A long-term cohort study显示文摘 | Grazia Anna Niro Antonina Smedile Antonio Massimo Ippolito Alessia Ciancio Rosanna Fontana Antonella Olivero Maria Rosa Valvano Maria Lorena Abate Domenica Gioffreda Gian Paolo Caviglia Mario Rizzetto Angelo Andriulli | 2010 | Journal of Hepatology2010，，5： | 1 |
| 8 | Reflection and transmission in anisotropic dissipative multilayers 显示文摘 | Caviglia G Morro A | 2002 | European Journal of Mechanics A/Solids2002，21，16： | 1 |
| 9 | Riccati equations for wave propagation in planarly-stratified solids显示文摘 | Caviglia G Morro A | 2000 | European Journal of Mechanics A/Solids2000，19，4： | 1 |
| 10 | Wave propagation in multilayered anisotropic solids显示文摘 | Caviglia G Morro A | 2000 | International Journal of Engineering Science2000，38，8： | 1 |
| 11 | Computation of longshore currents and sediment transport 显示文摘 | CAVIGLIA F J | 1994 | Computer & Geoseienees1994，20，6： | 1 |
| 12 | Taking the' U' out of kuznets - a comprehensive analysis of the EKC and environmental degradation 显示文摘 | Caviglia - Harris J L Chambers D Kahn J R | 2009 | Ecological Economics2009，68，4： | 1 |
| 13 | Uppergastrointestinal involvement of Crohn's disease: a prospectivestudy on the role of upper endoscopy in the diagnostic work-up显示文摘 | Annunziata ML Caviglia R Papparella LG | 2012 | Dig Dis Sci2012，57，6： | 1 |
| 14 | Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment:A 13-year experience at a single Italian institution显示文摘 | Castagnola E Caviglia I Pistorio A | 2005 | Eur J Cancer2005，41，10： | 1 |
| 15 | Upper Gastrointestinal Involvement of Crohn’s Disease: A Prospective Study on the Role of Upper Endoscopy in the Diagnostic Work-Up显示文摘 | Maria Annunziata Renato Caviglia Luigi Papparella Michele Cicala | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 16 | Harmonic waves in thermoviscoelastic solids显示文摘 | CAVIGLIA G MORRO A | 2005 | Int J Engng Sci2005，43，： | 1 |
| 17 | Pediatric Fractures of the humerus显示文摘 | Caviglia H Garrido CP Palazzi FF | 2005 | Clin Orthop Relat Res2005，，432： | 1 |
| 18 | Intercellular space diameters of the oesophageal epithelium in NERD patients= head to head comparison between light and electron microscopy analysis显示文摘 | Ribolsi M Perrone G Caviglia R | 2009 | Dig Liver Dis2009，41，1： | 1 |
| 19 | Chronic hepatitis B therapy: available drugs and treatment guidelines 显示文摘 | Caviglia GP Abate ML Pellicano R | 2015 | Minerva Gastroenterol Dietol2015，61，2： | 1 |
| 20 | Taking the 'U' out of Kuznets:a comprehensive analysis of the EKC and envi- ronmental degradation 显示文摘 | Jill L Caviglia H Dustin C | 2009 | Ecological Economics2009，68，4： | 1 |
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