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| 1 | PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer显示文摘Background:Programmed cell death ligand-1(PD-L1)and ligand-2(PD-L2)interaction with programmed cell death protein-1(PD-1)represent an immune-inhibiting checkpoint mediating immune evasion and is,accordingly,an important target for blockade-based immunotherapy in cancer.In non-small-cell lung cancer(NSCLC),improved understanding of PD-1 checkpoint blockade-responsive biology and identification of biomarkers for prediction of a clinical response to immunotherapy is warranted.Thus,in the present study,we systematically described PD-L1 and PD-L2 expression correlated genes in NSCLC.Methods:We performed comparative retrospective analyses to identify PD-L1 and PD-L2 mRNA expression corre-lated genes in NSCLC.For this,we examined available datasets from the cancer cell line encyclopedia(CCLE)project lung non-small-cell(Lung_NSC)and the cancer genome atlas(TCGA)projects lung adenocarcinoma(LUAD)and squamous cell carcinoma(LUSC).Results:Analysis of the CCLE dataset Lung_NSC identified expression correlation between PD-L1 and PD-L2.Moreo-ver,we identified expression correlation between 489 genes and PD-L1,191 genes and PD-L2,and 111 genes for both.PD-L1 and PD-L2 also expression correlated in TCGA datasets LUAD and LUSC.In LUAD,we identified expression corre-lation between 257 genes and PD-L1,914 genes and PD-L2,and 211 genes for both.In LUSC,we identified expression correlation between 26 genes and PD-L1,326 genes and PD-L2,and 13 genes for both.Only a few genes expression correlated with PD-L1 and PD-L2 across the CCLE and TCGA datasets.Expression of Interferon signaling-involved genes converged in particular with the expression correlated genes for PD-L1 in Lung_NSC,for PD-L2 in LUSC,and for both PD-L1 and PD-L2 in LUAD.In LUSC,PD-L1,and to a lesser extent PD-L2,expression correlated with chromosome 9p24 localized genes,indicating a chromosome 9p24 topologically associated domain as an important driver of in particu-lar LUSC PD-L1 expression.Expression correlation analyses of the PD-L1 and PD-L2 receptors programmed cell death protein-1(PD-1),Cluster of differentiation 80(CD80),and Repulsive guidance molecule B(RGMB)showed that PD-1 and CD80 expression correlated with both PD-L1 and PD-L2 in LUAD.CD80 expression correlated with PD-L2 in LUSC.Conclusions:We present gene signatures associated with PD-L1 and PD-L2 mRNA expression in NSCLC which could possess importance in relation to understand PD-1 checkpoint blockade-responsive biology and development of gene signature based biomarkers for predicting clinical responses to immunotherapy. | Trine Vilsbøll Larsen Dianna Hussmann Anders Lade Nielsen | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | Giant saphenous vein graft pseudoaneurysm to right posterior descending artery presenting with superior vena cava syndrome显示文摘Saphenous vein grafts(SVG) pseudoaneurysms,especially giant ones,are rare and occur as a late complication of coronary artery bypass grafting. This condition affects both genders and typically occurs within the sixth decade of life. The clinical presentation ranges from an asymptomatic incidental finding on imaging studies to new onset angina,dyspnea,myocardial infarction or symptoms related to compression of neighboring structures. An 82-year-old woman presented with acute onset back pain,dyspnea and was noted to have significantly engorged neck veins. In the emergency department,a chest computed tomographic angiogram with intravenous contrast revealed a ruptured giant bilobed SVG pseudoaneurysm to the right posterior descending artery(RPDA). This imaging modality also demonstrated compression of the superior vena cava(SVC) by the SVG pseudoaneurysm. Coronary angiogram with bypass study was performed to establish the patency of this graft. Endovascular coiling and embolization of the SVG to RPDA was initially considered but disfavored after the coronary angiogram revealed preserved flow from the graft to this arterial branch. After reviewing the angiogram films,a surgical strategy was favored over a percutaneous intervention with a Nitinol self-expanding stent since the latter would have not addressed the superior vena cava compression caused by the giant pseudoaneurysm. Intraoperative transesophageal echocardiogram demonstrated SVCcompression by the giant pseudoaneurysm cranial lobe. Our patient underwent surgical ligation and excision of the giant pseudoaneurysm and the RPDA was regrafted successfully. In summary,saphenous vein grafts pseudoaneurysms can be life-threatening and its therapy should be guided based on the presence of mechanical complications,the patency of the affected vein graft and the involved myocardial territory viability. | Andres Vargas-Estrada Dianna Edwards Mohammad Bashir James Rossen Firas Zahr | 2015 | World Journal of Cardiology2015，7，6： | 3 |
| 3 | The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: An updated meta-analysis显示文摘 | Philippa J. Delahoy Dianna J. Magliano Kate Webb Mendel Grobler Danny Liew | 2009 | Clinical Therapeutics2009，，2： | 2 |
| 4 | 头皮糠疹与巯氧吡啶锌显示文摘头皮糠疹是常见病和多发病,临床表现为头皮红斑和脱屑,提示皮损部位表皮结构和功能异常,头皮角质层代谢紊乱。最近对头皮糠疹病因和病理的研究证实马拉色菌、皮脂分泌和个体敏感性是形成上述皮损的3个关键因素。巯氧吡啶锌(PTZ或ZPT)可以有效地杀灭马拉色菌,PTZ的颗粒大小和形状对其在头皮的生物利用度有明显的影响。此外,PTZ的抗菌效果有赖于其分子结构的完整性,在外用制剂中加入附加的游离锌,可以有效防止PTZ解离,从而提高其疗效。 | 范卫新 戴叶琴 Schwartz JR Dawson TL Jr Dianna Kenneally 王玥 | 2006 | 临床皮肤科杂志2006，35，4： | 2 |
| 5 | The effects of temperature and nutrients on the growth and dynamics of toxic and non-toxic strains of Microcystis during cyanobacteria blooms显示文摘 | Timothy W. Davis Dianna L. Berry Gregory L. Boyer Christopher J. Gobler | 2009 | Harmful Algae2009，，5： | 2 |
| 6 | Strategies for formulating apropriate MDCT tehniques when imaging the chest,abdmen,and pelvis in pedianents patients显示文摘 | Dianna DC Donna MM Kerry TK | 2004 | AJR2004，182，： | 1 |
| 7 | Cognitive function in 18-month-old term infants of the DIAMOND study: A randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid显示文摘 | James R. Drover Dennis R. Hoffman Yolanda S. Casta?eda Sarah E. Morale Sharon Garfield Dianna H. Wheaton Eileen E. Birch | 2011 | Early Human Development2011，，3： | 1 |
| 8 | Phase Ⅱ study of capecitabine incombination with thalidomide inpatients with metastatic breast cancer 显示文摘 | Howard A Burris Suzanne F Jones Dianna Shipley | 2010 | Cancer Invest2010，28，4： | 1 |
| 9 | 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease显示文摘 | Loren F. Hiratzka George L. Bakris Joshua A. Beckman Robert M. Bersin Vincent F. Carr Donald E. Casey Kim A. Eagle Luke K. Hermann Eric M. Isselbacher Ella A. Kazerooni Nicholas T. Kouchoukos Bruce W. Lytle Dianna M. Milewicz David L. Reich Souvik Sen Jul | 2010 | Journal of the American College of Cardiology2010，，14： | 1 |
| 10 | Terraced self assembled nano-structures from laminarin显示文摘 | Dave E Dianna G | 2007 | International Journal of Biological Macromoleeules2007，40，4： | 1 |
| 11 | 2009 Pandemic influenza A(H1N1) pathology and pathogenesis of 100 fatal cases in the United States显示文摘 | Wun-Ju Shieh Dianna M Blau Amy M Denison | 2010 | The American Journal of Pathology2010，177，1： | 1 |
| 12 | Protein and amino acid composition of silks from the cob weaver, Latredectus hesperus显示文摘 | Merri Lynn Casem Dianna Turner Kelly Houchin | 1999 | International Journal of Biological Macromolecules1999，，24： | 1 |
| 13 | Plants in a cold climate 显示文摘 | Maggie Smallwood Dianna J Bowles | 2002 | Philosophical Transactions of the Royal Society B: Biological Sciences2002，357，1423： | 1 |
| 14 | The genetics of colored sequence synesthesia: Suggestive evidence of linkage to 16q and genetic heterogeneity for the condition显示文摘 | Steffie N. Tomson Nili Avidan Kwanghyuk Lee Anand K. Sarma Rejnal Tushe Dianna M. Milewicz Molly Bray Suzanne M. Leal David M. Eagleman | 2011 | Behavioural Brain Research2011，，1： | 1 |
| 15 | Hyaluronidase 3 ( HYAL3 ) knockout mice do not display evidence of hyaluronan accumulation显示文摘 | Vasantha Atmuri Dianna C. Martin Richard Hemming Alex Gutsol Sharon Byers Solmaz Sahebjam James A. Thliveris John S. Mort Euridice Carmona Judy E. Anderson Shyamala Dakshinamurti Barbara Triggs-Raine | 2008 | Matrix Biology2008，，8： | 1 |
| 16 | Protein and amino acid composition of silks from the cob weaver black w widow 显示文摘 | Dianna T Merri LC Kelly H | 1999 | Biological Macromolecules1999，24，： | 1 |
| 17 | Neighborhood food environment and area deprivation: spatial accessibility to grocery stores selling fresh fruit and vegetables in urban and rural settings显示文摘 | Dianna M Smith Steven Cummins Mathew Taylor | 2010 | International Journal of Epidemiology2010，39，： | 1 |
| 18 | Integration of a peer provider in a mental health clinic:Perspectives from a peer provider and a clinic director 显示文摘 | DIANNA D JUANA Y | 2012 | Psychia Rehabilita J2012，35，5： | 1 |
| 19 | Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms显示文摘 | Ellen S. Regalado Dong-chuan Guo Carlos Villamizar Nili Avidan Dawna Gilchrist Barbara McGillivray Lorne Clarke Francois Bernier Regie L. Santos-Cortez Suzanne M. Leal Aida M. Bertoli-Avella Jay Shendure Mark J. Rieder Deborah A. Nickerson Dianna M. Milew | 2011 | Circulation Research2011，，6： | 1 |
| 20 | The role of stress in symptom exacerbation among IBS patients显示文摘 | Edward B. Blanchard Jeffrey M. Lackner James Jaccard Dianna Rowell Ann Marie Carosella Catherine Powell Kathryn Sanders Susan Krasner Eric Kuhn | 2008 | Journal of Psychosomatic Research2008，，2： | 1 |
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