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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | N-acetylcysteine effects on genotoxic and oxidative stress parameters in cirrhotic rats with hepatopulmonary syndrome 显示文摘 | Vercelino R Tieppo J Dias AS | 2008 | Basic Clin Pharmacol Toxicol2008，102，4： | 1 |
| 3 | Adherence to the items in a bun- dle for the prevention of ventilator-associated pneumonia 显示文摘 | Sachetti A Rech V Dias AS | 2014 | Rev Bras Ter Intensiva2014，26，4： | 1 |
| 4 | Quercetin decreases oxidative stress,NF-{kappa} B activation,and iNOS overexpression in liver of streptozotocin-induced diabetic rats显示文摘 | Dias AS Porawski M Alonso M | 2005 | J Nutr2005，135，10： | 1 |
| 5 | Ibuprofen reverts antifungal resistance on Candida albicans showing overexpression of CDR genes 显示文摘 | Ricardo E Costa - de - Oliveira S Dias AS | 2009 | FEMS Yeast Res2009，9，4： | 1 |
| 6 | Does a firebreak' full-thickness skin graft prevent recurrence after surgery for Dupuytren's eontracture: a prospective, randomised trial 显示文摘 | Ullah AS Dias JJ Bhowal B | 2009 | J Bone Joint Surg Br2009，91，3： | 1 |
| 7 | Renal GLUT1 reduction depends on angiotensin-converting enzyme inhibition in diabetic hypertensive rats显示文摘 | Da Silva AS Dias LD Borges JF | 2013 | Life sciences2013，26，8： | 1 |
| 8 | Does a “firebreak” full-thicknessskin graft prevent recurrence after surgery for Dupuytren/ s con-tracture :a prospective,randomised trial 显示文摘 | Ullah AS Dias JJ Bhowal B | 2009 | J Bone Joint SurgBr2009，91，3： | 1 |
| 9 | Adherence to the items in a bundle for the prevention of ventilator-associated pneu- monia显示文摘 | Sachetti A Rech V Dias AS | 2014 | Rev Bras Ter Intensiva2014，26，4： | 1 |
| 10 | Use of biochar as bulking agent for the composting of poultry manure: Effect on organic matter degradation and humification 显示文摘 | DIAS B O SILVA C A HIGASHIKAWA F S ROIG AS NCHEZ-MONEDERO M A | 2010 | Bioresource Technology2010，101，4： | 1 |
| 11 | Adherence to the items in a bundle for the prevention of ventilator-associated pneumonia 显示文摘 | Sachetti A Rech V Dias AS | 2014 | Rev Bras Ter Intensiva2014，26，4： | 1 |
| 12 | Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats显示文摘 | Dias AS Porawski M Alonso M | 2005 | J Nutr2005，135，： | 1 |
| 13 | Effects of the oral administration of viable and heat-killed Streptococcus bovis HC5 cells to pre-sensitized BALB/c mice 显示文摘 | Paiva AD Fernandes KM Dias RS Rocha AS de Oliveira LL Neves CA de Paula SO Mantovani HC | 2012 | PLoS One2012，7，48： | 1 |
| 14 | Increased Na + and Cl ? accumulation induced by NaCl salinity inhibits cotyledonary reserve mobilization and alters the source-sink relationship in establishing dwarf cashew seedlings显示文摘 | Elton Camelo Marques Paulo André Ferreira Freitas Nara Lídia Mendes Alencar José Tarquinio Prisco Enéas Gomes-Filho | 2013 | Acta Physiologiae Plantarum2013，，7： | 1 |
| 15 | Quercetin decreases oxidative stress,NF-kappaB activation,and iNOS overexpression in liver of streptozotocin-induced diabetic rats显示文摘 | Dias AS Porawski M Alonso M | 2005 | J Nutr2005，135，10： | 1 |
| 16 | The impact of patients controlled analgesia undergoing orthopedic surgery 显示文摘 | Dias AS Rinaldi T Barbosa LG | 2016 | Braz J Anesthesiol2016，66，3： | 1 |
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