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| 1 | Hepatitis C virus syndrome: A constellation of organ-and non-organ specific autoimmune disorders, B-cell nonHodgkin's lymphoma, and cancer显示文摘The clinical course of chronic hepatitis C virus(HCV)infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinicoepidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells nonHodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCVrelated thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases. | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Michele Colaci Poupak Fallahi Alessia Piluso Alessandro Antonelli Anna Linda Zignego | 2015 | World Journal of Hepatology2015，7，3： | 11 |
| 2 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 3 | Reaetive arthritis induced by intravesical BCG therapy for bladder cancer: Our clinical experience and systematic review of the literature显示文摘 | Luigi Bemini Carlo Umberto Manzini Dilia Giuggioli | 2013 | Autoimmunity Reviews2013，6，29： | 1 |
| 4 | Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients显示文摘 | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Massimiliano Cazzato Giovanni Longombardo Alessandro Antonelli Rodolfo Puccini Claudio Michelassi Anna Linda Zignego | 2004 | Seminars in Arthritis and Rheumatism2004，，6： | 1 |
| 5 | Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients显示文摘 | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Massimiliano Cazzato Giovanni Longombardo Alessandro Antonelli Rodolfo Puccini Claudio Michelassi Anna Linda Zignego | 2004 | Seminars in Arthritis and Rheumatism2004，，6： | 1 |
| 6 | Chemokine (C–X–C motif) ligand (CXCL)10 in autoimmune diseases显示文摘 | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Ele Ferrannini Clodoveo Ferri Poupak Fallahi | 2013 | Autoimmunity Reviews2013，，： | 1 |
| 7 | Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients显示文摘 | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Massimiliano Cazzato Giovanni Longombardo Alessandro Antonelli Rodolfo Puccini Claudio Michelassi Anna Linda Zignego | 2004 | Seminars in Arthritis and Rheumatism2004，，6： | 1 |
| 8 | Successful eradication of the European rabbit(Oryctolagus cuniculus)and house mouse(Mus musculus)from the island of Selvagem Grande(Macaronesian archipelago),in the Eastern Atlantic显示文摘The Portuguese island of Selvagem Grande(Great Salvage)in Macaronesia is an important seabird breeding station in the eastern Atlantic.Significant populations of Cory’s shearwater Calonectris diomedea(Scopoli,1769),Bulwer’s petrel Bulweria bulweria(Jardine&Selby,1828)and little shearwater Puffinus assimilis baroli(Bonaparte,1857)are present,and white-faced storm-petrel Pelagodroma marina(Latham,1790)and Madeiran storm-petrel Oceanodroma castro(Harcourt,1851)populations are of global significance.Selvagem Grande also provides diverse habitats for an extensive flora,including 11 endemic species.The 270-ha island was also inhabited by two alien invasive mammals:the European rabbit Oryctolagus cuniculus(Linnaeus,1758)and the house mouse Mus musculus(Linnaeus,1758).Both are known to have had adverse impacts on breeding seabirds and island vegetation.In 2002,the Natural Park of Madeira conducted a program using brodifacoum bait formulations aimed at rabbit and mouse eradication.Approximately 17000 individual baiting points were established on a 12.5×12.5 m grid.Baits were also applied by hand“seeding”on steep slopes and cliffs where bait stations could not be placed.Rabbits were removed after a month.However,mice persisted for considerably longer and strategic bait applications against them continued for a further six months.Subsequent assessments by trapping,bait takes and systematic observa-tion of signs over three years,has confirmed the removal of both alien invasive species.This paper presents information on these operations,on measures adopted to mitigate adverse impacts of the eradication program on important vertebrate non-target species,including Berthelot’s pipit Anthus berthelotii Bolle,1862 and a species of gecko Tarentola bischoffi Joger,1984 and on the initial response of the island’s ecosystem to the eradication of rabbits and mice. | Paulo OLIVERA Dilia MENEZES Roger TROUT Alan BUCKLE Pedro GERALDES JoséJESUS | 2010 | Integrative Zoology2010，5，1： | 0 |
| 9 | Seasonal variation in native hydraulic conductivity between two deciduous oak species显示文摘植物抗旱性机制包括耐旱性和避旱性。耐旱性的特征主要是木质部易栓塞性和膨压损失点,而避旱性的特征则是叶片脱落和落叶性。虽然这些机制可以权衡物种连续性,但对于干旱引发的叶片脱落和持续时间的变化如何影响木质部和叶片耐受性之间的关系却知之甚少。在本研究中,我们研究两种具有不同叶片脱落叶行为的橡树(栎属)的耐旱性程度差异。我们预测了Quercusdeserticola在旱季结束时落叶(晚落叶)而面临更大的空化风险,导致其比Q.laeta更耐旱,对水分的利用也更加保守。Q.laeta只在旱季中期很短的时间内落叶(短落叶)。本研究在墨西哥中部进行,两种橡树各具有单个种群,它们之间相距1.58公里,海拔差为191米。Q.deserticola(晚落叶)多出现在下坡,而Q.laeta(短落叶)多出现在沿坡度海拔较高的地方。我们评估了样地内茎干的水分传导率的季节差异(雨季和旱季),并检测了两个物种间木质部对空化的脆弱性、叶片水分利用和叶片膨松损失点的差异。两种橡树在耐旱性状方面没有显著差异,主要包括木质部易栓塞性、叶片膨松损失点和气孔导度。然而,两种植物在旱季都有不同的表现:短落叶植物对木质部功能的负面影响要比晚落叶植物低。综上所述,两种橡树在植物生理性能方面的季节变化取决于冠层叶面积的减少。 | Dilia Mota-Gutiérrez Guadalupe Arreola-González Rafael Aguilar-Romero Horacio Paz Jeannine Cavender-Bares Ken Oyama Antonio Gonzalez-Rodriguez Fernando Pineda-García | 2020 | Journal of Plant Ecology2020，13，1： | 0 |
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