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| 1 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 2 | HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro显示文摘瞄准:与丙肝的长期的复制建立一个房间文化系统病毒(HCV ) 染色体和病毒的抗原的表示在试管内。方法:HepG2 房间线被孵化与长期的丙肝从一个病人与浆液为它的危险性测试到 HCV。房间和上层清液在文化期间在各种各样的时间点被收获。文化上层清液为它感染天真的房间的能力被测试。存在减(反感觉) 在房间的核心和 E1 抗原的 RNA 海滨,和察觉被 RT-PCR 和免疫学的技术(流动血细胞计数和西方的污点) 分别地检验。结果:细胞内部的 HCV RNA 首先在 d 上被检测 3 在感染以后然后能一致地在至少三个月的一个时期上在房间和上层清液被检测。新鲜房间能从有教养的感染的房间感染上层清液。流动 cytometric 分析证明表面和在房子里使用的细胞内部的 HCV 抗原表示使 polyclonal 成为了抗体(反核心,和 anti-E1 ) 。西方的污点分析证明在分子量的产生免疫性的肽的簇的表示在一个月内在 31 和 45 kDa 之间延长了感染的房间的旧文化而这簇在 uninfected HepG2 房间是无法发现的。结论:HepG2 房间线产生 HCV 感染而且支持它的复制在试管内不仅。HCV 结构的蛋白质的表示能在感染的 HepG2 房间被检测。这些房间也能够流病毒的粒子进接着对 uninfected 房间变得传染的培养基。 | Mostafa K El-Awady Ashraf A Tabll Yasmine S El-Abd Mahmoud M Bahgat Hussein A Shoeb Samar S Youssef Noha G Bader El Din El-Rashdy M Redwan Maha El-Demellawy Moataza H Omran Wael T El-Garf Said A Goueli | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 3 | Modifica- tions in energy demand in urban areas as aresult of climate changes: an assessment for thesoutheast Mediterranean region显示文摘 | CARTALIS C SYN DIN u A PROEDROU M | 2001 | Energy Conversion&Management2001，42，14： | 1 |
| 4 | Surgical manage- ment of constipation 显示文摘 | Knowlcs CH Dinning PG Pescatori M | 2009 | Neurogastroenterol Motil2009，21，2： | 1 |
| 5 | D1 and D2 dopamine receptor modulation of striatal glut amatergic signaling in striatal medium spiny neurons 显示文摘 | SURMEIER DJ DIN GJ DAY M | 2007 | Trends Neurosci2007，30，5： | 1 |
| 6 | An Electrochemical and Esca Study on the Tarnishing of Silver in Solutions of Different pS and pH Values显示文摘 | DIN A M Shams El KADER J M Abd El WAHAB F M Abd El | 1985 | Electrochimica Acta1985，30，4： | 1 |
| 7 | Adsorption of methylene blue onto bamboo-based activated carbon: kinetics and equilibrium studies 显示文摘 | Hameed B H Din A T M Ahmad A L | 2007 | J Hazard Mate2007，141，3： | 1 |
| 8 | Stress intensity factors for fatigue cracking of round bars 显示文摘 | Din A S S E Lovegrove J M | 1981 | International Journal of Fatigue1981，3，3： | 1 |
| 9 | The use of oryzalin as an alternative for colchicine inin-vitro chromosome doubling of Lilium and Nerine显示文摘 | Van TUYL J M MEIJER B Van DIN M P | 1992 | Acta Hort1992，325，： | 1 |
| 10 | Optimization of nitrogen and phosphorus limitation for better biodegradable plastic production and organic removal using single fed- batch mixed cultures and renewable resources 显示文摘 | Din M F Ujang Z van Loosdrecht M C | 2006 | Water Science and Technology2006，53，6： | 1 |
| 11 | Lactococ- cus lactis - expressing listeriolysin O ( LLO ) provides protection and specific CD8 ( + ) T cells against Listeria monocytogenes in the murine infection model显示文摘 | BAHEY EL DIN M CASEY P G GRIFFIN B T | 2008 | Vaccine2008，26，41： | 1 |
| 12 | Wheat gluten: high molecular weight glutenin subunits-structure, genetics, and relation to dough elasticity 显示文摘 | Anjum F M Khan M R Din A | 2007 | Journal of Food Science2007，72，3： | 1 |
| 13 | Adsorption of methylene blue onto bamboo - based activated car- bon:Kinetics and equilibrium studies 显示文摘 | Hameed B H Din A T M Ahmad A L | 2007 | J Hazard Mater2007，141，： | 1 |
| 14 | Protective efficacy of recombinant modified vaccinia virus ankara delivering middle east respiratory syndrome coronavirus spike glycoprotein显示文摘 | Volz A Kupke A Song F Jany S Fux R Shams-El- din H Schmidt J Becker C Eickmann M Becker S Sutter G | 2015 | J Virol2015，89，16： | 1 |
| 15 | Adsorption of methylene blue onto bamboo-based activated carbon: Kinetics and equilibrium studies 显示文摘 | Hameed B H Din A T M Ahmad A L | 2007 | J Hazardous Mater2007，141，3： | 1 |
| 16 | Three strategies for combating the corrosion of steel pipes carrying desalinated potable water 显示文摘 | Shams E1 Din A M | 2009 | Desalination2009，238，： | 1 |
| 17 | Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis显示文摘 | Din?AE C?mert F Damar M | 2016 | Eur Arch Otorhinolaryngol2016，273，34： | 1 |
| 18 | Circumferential mucosec- tomy( stapled haemorrhoidectomy) versus convevtional haemor- rhoideetomyrandomized controlled tral显示文摘 | Rowsell M Bello M He mingway Din | 2000 | Lancet2000，35，5： | 1 |
| 19 | The diverse applications of water hyacinth with main focus on sustainable energy and production for new era:An overview显示文摘 | REZANIA S PONRAJ M DIN M F M | 2015 | Renewable and Sustainable Energy Re- views2015，41，： | 1 |
| 20 | Neurogenic and myogenic motor patterns of rabbit proximal, mid, and distal colon 显示文摘 | Dinning PG Costa M Brookes SJ | 2012 | Am J Physiol Gastrointest Liver Physiol2012，303，1： | 1 |
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