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您的检索式：作者名="Ding Bojiang"
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| 1 | 查看详情显示文摘 | Ding Bojiang Kuang Guangli Shan Jiafang | | 0，，： | 1 |
| 2 | Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response显示文摘More and more patients with advanced colorectal cancer(CRC)have benefited from surgical resection or ablation following neoadjuvant chemoradiotherapy(nCRT),but nCRT may be ineffective and have potential risks to some patients.Therefore,it is necessary to discover effective biomarkers for predicting the nCRT efficacy in CRC patients.Chromokinesin Kif4A plays a critical role in mitosis,DNA damage repair and tumorigenesis,but its relationship with nCRT efficacy in advanced CRC remains unclear.Here,we find that Kif4A expression in pretreated tumor tissue is positively correlated with poorer tumor regression after receiving nCRT(P=0.005).Knockdown of endogenous Kif4A causes an increased sensitivity of CRC cells to chemotherapeutic drugs 5-fluorouracil(5-FU)and Cisplatin(DDP),while overexpression of Kif4A enhances resistance of CRC cells to the chemotherapeutic drugs.Furthermore,depending on its motor domain and tail domain,Kif4A regulates DNA damage response(DDR)induced by 5-FU or DDP treatment in CRC cells.In conclusion,we demonstrate that Kif4A may be a potential independent biomarker for predicting the nCRT efficacy in advanced CRC patients,and Kif4A regulates chemosensitivity of CRC cells through controlling DDR. | Rui Zhang Shuanghui Liu Bojiang Gong Wenran Xie Youjuan Zhao Liang Xu Yi Zheng Shengnan Jin Chunming Ding Chang Xu Zhixiong Dong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 3 | Studies of high confinement plasma with lower hybrid current drive in the HT-7 superconducting tokamak显示文摘 | Ding Bojiang Kuang Guangli Shan Jiafang | 2003 | Nucl Fusion2003，43，7： | 1 |
| 4 | Experimental Investigation of Lower Hybrid Wave Coupling in HT-7显示文摘Experiments on lower hybrid wave(LHW)coupling were investigated in the HT-7 tokamak.Good coupling of LHW plasma has been demonstrated at different conditions in the HT-7 tokamak.Relevant results have proved that LHW-plasma coupling is affected by the phase difference between adjacent waveguides.Furthermore,the edge density around the grill and relevant coupling can be adjusted by changing the plasma line average density or the gap value between the LH grill and the last closed flux surfaces(LCFS).It is found that the coupling of LHWs becomes poor when the edge density around the LH grill is large enough in the HT-7tokamak,and that coupling remains good with a proper edge density.With increasing LHW power,it is also found that the reflection coefficients(RCs)increase due to non-linear effects under conditions of low edge recycling,but can decrease under high edge recycling.The edge density depends mainly on the competition between the ponderomotive force(PMF)and the edge recycling intensity in the HT-7 tokamak. | KONG Erhua DING Bojiang ZHANG Ting QIN Yongliang SHAN Jiafang LIU Fukun LI Miaohui ZHANG Lei WANG Mao LIU Liang XU Handong JIA Hua WU Zege FENG Jianqiang ZHAO Lianmin YANG Yong | 2013 | Plasma Science and Technology2013，15，10： | 0 |
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