3篇
您的检索式：作者名="Ding Daxiong"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Auditory characteristics of noise-exposed memberscrossing age-related groups显示文摘Objective: To report audiological characteristics in a group of noise-exposed crew members on board ships.Methods and materials: Clinical and audiological measurements including pure-tone thresholds, acoustic immittance results and tinnitus questionnaires were collected from both the ship crew members(study subjects) and their land based colleagues(controls).Results: 1) Noise exposed crew members showed not only high frequency, but also low frequency hearing loss; 2) Hearing impairment increased with age, with 65.5% of crew members younger than 50 years showing normal hearing while only 14.9% of those older than 50 years had normal hearing; 3)hearing loss gradually increased with the extension of on board career time; and 4) Most study subjects reported high pitch tinnitus, significantly more than the control group although not significantly different among different age groups.Conclusion: Noise induced hearing impairment from working on board ships shows specific frequency and age characteristics. Understanding these characteristics is important for advancing relevant studies and for effective prevention of noise-induced hearing loss in ship crew members. | Liu Chenqing Ding Daxiong Zhu Yuhua Wang Hongyang Cheng Xiaoting Zhao Zhenhua Cao Juyang Zhai Suoqiang Yu Ning | 2018 | Journal of Otology2018，13，2： | 3 |
| 2 | Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors显示文摘In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with diverse structures,a series of novel S-DACO analogues of 6-(2-cyclohexyl-1-allkyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)pyrimidin-4(3 H)-ones were designed,synthesized and evaluated for their antiviral activities in MT-4 cells.Most of these new compounds showed moderate to good activities against wild type HIV-1 with IC_(50) values ranging from 7.55μmol/L to 0.018μmol/L.Among them,compound 5 c was identified as the most promising inhibitor against HIV-1 replication with an IC_(50)=0.018μmol/L,CC_(50)=194μmol/L,and SI=12791,which was much more potent than the reference drugs NVP and DLV and comparable to AZT and EFV.In addition,5 c also exhibited improved activity against double mutant HIV-1 strain RES056 compared to that of the reference drugs NVP/DLV and DB02.The preliminary structure-activity relationship(SAR)and molecular modeling studies were also discussed,which provides some useful indications for guiding the further rational design of new S-DACO analogues. | Daxiong Li Chunsheng Zhang Wei Ding Siming Huang Le Yu Nan Lu Wenkai Pan Yiming Li Erik De Clercq Christophe Pannecouque Hongbing Zhang Yueping Wang Yanping He Fener Chen | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 3 | Effects of intelligent feedingmethod on the growth,immunity and stress of juvenile Micropterus salmoides显示文摘The feeding method is of great significance for aquaculture production and cost.In recent years,research on intelligent feeding,a method based on fish appetite,has been trending.Fewstudies,however,have focused on fish welfare issues that can result from intelligent feeding.In this study,an adaptive feeder based on a practical intelligent feeding method was designed to evaluate whether this intelligent feeding method would impair fish welfare compared to traditional automatic feeding.The results indicated that the amount of residual feed and size inhomogeneity in the traditional group was significantly higher than that in the intelligent group.The results of the growth indicator showed that theweight gain rate(WGR)in the intelligent feeding groupwas significantly higher(30.17%)than in the traditional feeding group.Although no significant differences were observed in the survival rate(SR),the condition factor(CF)and the hepatosomatic index(HSI),the specific growth rate(SGR)in the intelligent feeding group was significantly increased by 8.33%while the feed conversion rate(FCR)was reduced by a remarkable 17.07%compared to the traditional feeding group.Moreover,intelligent feeding significantly improved the pepsin activity of the bass.In terms of immunity and antioxidant capacity,however,the fish in the intelligent feeding group had a significantly lower lysozyme(LZM)level than those fed with the traditional method.For superoxide dismutase(SOD),the intelligent group also displayed a lower activity value,although it was not significant.The intelligent feeding group had 0.14 nmol/mg protein higher malondialdehyde(MDA)activity than the traditional group.Regarding stress,although no statistical significance was observed,the cortisol level in the intelligent group was 1.9 ng/ml higher than in the traditional group.Together,these data suggested that the intelligent feeding method can significantly improve fish growth but may also result in stress and suppress innate immunity. | Dan Wei Fengdeng Zhang Zhangying Ye Songming Zhu Daxiong Ji Jian Zhao Fan Zhou Xueyan Ding | 2021 | Artificial Intelligence in Agriculture2021，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员