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| 1 | Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘Phosphatidylinositol 3 磷酸盐(PI3P ) 在小囊的 trafficking,细胞器生物的续生说和 autophagy 起必要作用。二班 III phosphatidylinositol 3-kinase (PI3KC3 ) 建筑群在哺乳动物, ATG14L 建筑群(PI3KC3-C1 ) 和 UVRAG 建筑群(PI3KC3-C2 ) 被识别了。PI3KC3-C1 为 autophagosome 生物的续生说是关键的,并且 PI3KC3-C2 涉及各种各样的膜 trafficking 事件。这里,我们在亚纳米分辨率报导人的 PI3KC3-C1 和 PI3KC3-C2 的 cryo 他们结构。二结构与不同特征分享普通塑造 L 的全面体系结构。他们检查直接表明 PI3KC3-C1 在类脂化合物单层上站起来,与 ATG14L 蝙蝠领域和 VPS34 C 终端领域(CTD ) 联系膜。生物化学的解剖显示 ATG14L 蝙蝠领域负责膜抛锚,而 VPS34 的 CTD 决定取向。而且, PI3KC3-C2 比 PI3KC3-C1 更微弱地绑在包含 PI liposomes 和净化的 endoplasmic 蜂窝胃(嗯) 泡,被 ATG14L 明确地决定的一个性质打领域。在里面 vivo 嗯本地化分析显示蝙蝠领域被要求为嗯 PI3KC3 的本地化。我们建议不同类脂化合物绑定能力是在 autophagy 区分 PI3KC3-C1 和 PI3KC3-C2 的函数的关键因素。 | Meisheng Ma Jun-Jie Liu Nan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu Hong-Wei Wang | 2017 | Cell Research2017，27，8： | 7 |
| 2 | Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation显示文摘 | Ding H Matthews TA Johnson GV | 2006 | J Biol Chem2006，281，19： | 1 |
| 3 | Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death显示文摘 | Matthews-Roberson TA Quintanilla RA Ding HJ | 2008 | Brain Res2008，1234，： | 1 |
| 4 | Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes显示文摘 | Graubert TA Shen D Ding L | 2011 | Nat Genet2011，44，1： | 1 |
| 5 | Evaluation of the ITI Morse taper implant/abutment design with an internal modification显示文摘 | Ding TA Woody RD Higginbottom FL | 2003 | Int J Oral Maxillofac Implants2003，18，： | 1 |
| 6 | Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes显示文摘 | Graubert TA Shen D Ding L | 2011 | Nat Gene t2011，44，1： | 1 |
| 7 | Evaluation of the ITI Morse taper implant/abutment design with an internal modification显示文摘 | Ding TA Woody RD Higginbottom FL | 2003 | Int J Oral Maxillofac Implants2003，18，： | 1 |
| 8 | Overexpression of FAK promotes Ras activity through the formation of a FAK/P120RasGAP complex in malignant cells 显示文摘 | Hecker TP Ding Q Rege TA | 2004 | Oncogene2004，23，22： | 1 |
| 9 | PQ1 a quinoline derivative,induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9显示文摘 | Ding Y Nguyen TA | 2013 | Apoptosis2013，18，9： | 1 |
| 10 | Recurrent mutations in the U2AFI splicing factor in myelodysplastic syn?dromes显示文摘 | Graubert TA Shen D Ding L | 2011 | Nat Genet2011，44，1： | 1 |
| 11 | Site-specific phosphorylation and easpase cleavage differentially impact tau-microtubule interractions and tau aggregation显示文摘 | Ding H Mathews TA Johnson GVW | 2006 | J Bio Chem2006，281，19： | 1 |
| 12 | Potential hepatotoxicity of geniposide,the major iridoid glycoside in dried ripe fruits of Gardenia jasminoides(Zhi-zi)显示文摘 | Ding Y Zhang T Ta J S | 2013 | Nat Prod Res2013，27，10： | 1 |
| 13 | Author Correction:Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘We apologize for errors that we inadvertently introduced in Fig.4C and Supplementary infoirnation,Figs.S5F,S4E and S6C,of the paper published online on July 21*2017.The bands of Ha-P150_C2-BATsw in Fig.4C,/,a-Beclin1_C1/,in Supplementary information,Fig.S5F,and'a-P150_C2+6%PI(4,5)P2'in Supplementary information,Fig.S6C were incorrectly cropped from the original western blot images.The labeling of'a-VPS34—VPS34 ACTD'and'0-VPS34—ATGML ABATs'in Supplementary information,Fig.S4E were flipped.The corrected figures are provided below. | Meisheng Ma Jun-Jie Liu Yan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu and Hong-Wei Wang | 2020 | Cell Research2020，30，6： | 0 |
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