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| 1 | Noninvasive model including right ventricular speckle tracking for the evaluation of pulmonary hypertension显示文摘AIM To find parameters from transthorathic echocardiography(TTE) including speckle-tracking(ST) analysis of the right ventricle(RV) to identify precapillary pulmonary hypertension(PH).METHODS Forty-four patients with suspected PH undergoing right heart catheterization(RHC) were consecutively included(mean age 63.1 ± 14 years, 61% male gender). All patients underwent standardized TTE including ST analysis of the RV. Based on the subsequent TTE-derived measurements, the presence of PH was assessed: Left ventricular ejection fraction(LVEF) was calculated by Simpsons rule from 4Ch. Systolic pulmonary artery pressure(s PAP) was assessed with continuous wave Doppler of systolic tricuspid regurgitant velocity and regarded raised with values ≥ 30 mmH g as a surrogate parameter for RA pressure. A concomitantly elevated PCWP was considered a means to discriminate between the precapillary and postcapillary form of PH. PCWP was considered elevated when the E/e' ratio was > 12 as a surrogate for LV diastolic pressure. E/e' ratio was measured by gauging systolic and diastolic velocities of the lateral and septal mitral valve annulus using TDI mode. The results were then averaged with conventional measurement of mitral valve inflow. Furthermore, functional testing with six minutes walking distance(6MWD), ECG-RV stress signs, NT pro-BNP and other laboratory values were assessed.RESULTS PH was confirmed in 34 patients(precapillary PH, n = 15, postcapillary PH, n = 19). TTE showed significant differences in E/e' ratio(precapillary PH: 12.3 ± 4.4, postcapillary PH: 17.3 ± 10.3, no PH: 12.1 ± 4.5, P = 0.02), LV volumes(ESV: 25.0 ± 15.0 mL, 49.9 ± 29.5 m L, 32.2 ± 13.6 m L, P = 0.027; EDV: 73.6 ± 24.0 mL, 110.6 ± 31.8 mL, 87.8 ± 33.0 mL, P = 0.021) and systolic pulmonary arterial pressure(sP AP: 61.2 ± 22.3 mm Hg, 53.6 ± 20.1 mm Hg, 31.2 ± 24.6 mm Hg, P = 0.001). STRV analysis showed significant differences for apical RV longitudinal strain(RVAS: -7.5% ± 5.6%, -13.3% ± 4.3%, -14.3% ± 6.3%, P = 0.03). NT pro-BNP was higher in patients with postcapillary PH(4677.0 ± 7764.1 pg/m L, precapillary PH: 1980.3 ± 3432.1 pg/mL, no PH: 367.5 ± 420.4 pg/mL, P = 0.03). Patients with precapillary PH presented significantly more often with ECG RV-stress signs(P = 0.001). Receiver operating characteristics curve analyses displayed the most significant area under the curve(AUC) for RVAS(cut-off < -6.5%, AUC 0.91, P < 0.001), sPAP(cut-off > 33 mmH g, AUC 0.86, P < 0.001) and ECG RV stress signs(AUC 0.83, P < 0.001). The combination of these parameters had a sensitivity of 82.8% and a specificity of 17.2% to detect precapillary PH. CONCLUSION The combination of non-invasive measurements allows feasible assessment of PH and seems beneficial for the differentiation between the pre- and postcapillary form of this disease. | Yossra Mahran Robert Schueler Marcel Weber Carmen Pizarro Georg Nickenig Dirk Skowasch Christoph Hammerstingl | 2016 | World Journal of Cardiology2016，8，8： | 4 |
| 2 | Materials and technologies for SOFC-components显示文摘 | Ellen Ivers-Tiffée André Weber Dirk Herbstritt | 2001 | Journal of the European Ceramic Society2001，，10： | 1 |
| 3 | A compact, low cost new concept cracker 显示文摘 | Martin Rothmann Dirk Weber | 2006 | Feed Tech2006，10，9： | 1 |
| 4 | Heat stress response in plants: a complex game with chaperones and more than twenty heat stress transcription factors显示文摘 | Sanjeev Kumar Baniwal Kapil Bharti Kwan Yu Chan Markus Fauth Arnab Ganguli Sachin Kotak Shravan Kumar Mishra Lutz Nover Markus Port Klaus-Dieter Scharf Joanna Tripp Christian Weber Dirk Zielinski Pascal Koskull-D?ring | 2004 | Journal of Biosciences2004，，4： | 1 |
| 5 | Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes显示文摘 | Oliver Soehnlein Maik Drechsler Yvonne D?ring Dirk Lievens Helene Hartwig Klaus Kemmerich Almudena Ortega‐Gómez Manuela Mandl Santosh Vijayan Delia Projahn Christoph D. Garlichs Rory R. Koenen Mihail Hristov Esther Lutgens Alma Zernecke Christian Weber | 2013 | EMBO Mol Med2013，，3： | 1 |
| 6 | Materials and technologies for SOFC -components 显示文摘 | ELLEN IVERS - TIFFEE ANDRE WEBER DIRK HERBSTRITT | 2001 | J The European Ceramic Society2001，21，： | 1 |
| 7 | Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor- κ B, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes显示文摘 | Miriam Maraslioglu Elsie Oppermann Carolin Blattner Roxane Weber Dirk Henrich Christian Jobin Elke Schleucher Ingo Marzi Mark Lehnert Elizabeth J. Kovacs | 2014 | Mediators of Inflammation2014，，： | 1 |
| 8 | Combined laparoscopic–endoscopic resections of colorectal polyps: 10-year experience and follow-up显示文摘 | Dirk Wilhelm Stefan Delius Lars Weber Alexander Meining Armin Schneider Helmut Friess Roland M. Schmid Eckart Frimberger Hubertus Feussner | 2009 | Surgical Endoscopy2009，，4： | 1 |
| 9 | Ecological characterization of soil-inhabiting and hypolithic soil crusts within the Knersvlakte,South Africa显示文摘Introduction:Within the Knersvlakte,cyanobacteria occur hypolithically underneath translucent quartz stones in areas with quartz pavement and,outside pavement areas,they are soil-inhabiting within the uppermost millimeters of the soil.Both habitats were characterized in terms of biomass and growth patterns of cyanobacteria.Long-term microclimatic conditions were determined.Methods:Biomass of organisms within both habitats was determined by means of chlorophyll analyses.A transect approach was used to determine the frequency of hypolithic growth depending on the size,weight,and embedding depth of the quartz pebbles.Organisms were identified by means of microscopic analyses of the samples.Microclimatic conditions within both habitats,i.e.,temperature,light intensity,air humidity,and soil moisture,were recorded bi-hourly from September 23,2004 through September 7,2006.Results:The biomass of hypolithic and soil-inhabiting crusts was almost identical,88 vs.86 mg Chla/m^(2)and 136 vs.134 mg Chla+b/m^(2).Within the quartz fields,46.8%of the surface area was covered by quartz stones with 69%of translucent quartz stones colonized by hypolithic cyanobacteria and algae.Colonized quartz stones were significantly thicker,heavier,and more deeply embedded in the soil than uncolonized ones.Whereas the annual mean temperature on top of quartz stones was nearly identical to that underneath thin and thick quartz stones,daily temperature amplitudes were largest on the stone surface(up to 48.1K),compared to the hypolithic habitats(up to 39.4K).Light intensity in the hypolithic habitat was between 15 and 30%of the ambient light intensity during daytime.Water condensation in the absence of rain occurred during 50%of the nights on the quartz stone surface,but only during 34%of the nights on the soil surface during winter months within 1 year.Soil moisture beneath quartz layers was greater and less variable than beneath soil-inhabiting crusts.Conclusions:In spite of the large differences in the microclimatic conditions,both habitats seem to be similarly well suited for cyanobacterial growth,resulting in equal biomass values but some differences in taxonomic composition. | Bettina Weber Dirk CJ Wessels Kirstin Deutschewitz Stephanie Dojani Hans Reichenberger Burkhard Büdel | 2013 | Ecological Processes2013，2，1： | 0 |
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