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| 1 | Micro RNAs in the development of non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease or nonalcoholic fatty liver disease(NAFLD) refers to a group of disorders that arise from the accrual of fat in hepatocytes. Although various factors have been associated with the development of NAFLD, including genetic predisposition and environmental exposures, little is known aboutthe underlying pathogenesis of the disease. Research efforts are ongoing to identify biological targets and signaling pathways that mediate NAFLD. Emerging evidence has implicated a role for micro RNAs(mi RNAs), short single-stranded molecules that regulate gene expression either transcriptionally, through targeting of promoter regions, or post-transcriptionally, by blocking translation or promoting cleavage of specific target m RNAs. Several mi RNAs have been associated with NAFLD, although our understanding of the biology underlying their role is still emerging. The goal of this review is to present an overview of the current state of knowledge of mi RNAs involved in the development of NAFLD across a range of in vitro and in vivo models, including mi RNAs that contribute to pathological mechanisms related to fatty liver in humans. Much less is known about the specific targets of mi RNAs in cells, nor the molecular mechanisms involved in the development and progression NAFLD and related outcomes. More recently, the identification and validation of mi RNA signatures in serum may facilitate the development of improved methods for diagnosis and clinical monitoring of disease progression. | Glenn S Gerhard Johanna K DiStefano | 2015 | World Journal of Hepatology2015，7，2： | 5 |
| 2 | Clinicalappointment process: improvement through schedule defragmentation 显示文摘 | Lian J Distefano K Shields SD | 2010 | IEEE Eng Med Biol Mag2010，29，2： | 1 |
| 3 | Job satisfaction Issues and Problem 显示文摘 | Foumet G P Distefano M K Jr & Pryer M W | 1966 | Personnel Psychology1966，，19： | 1 |
| 4 | Clinical appointment process:improvement through schedule defragmentation显示文摘 | Lian J Distefano K Shields SD | 2010 | IEEE Eng Med Biol Mag2010，29，2： | 1 |
| 5 | Chitinases and immunity : Ancestral molecules with new functions 显示文摘 | Di RM Distefano G Zorena K | 2016 | Immunobiology2016，221，3： | 1 |
| 6 | Technological issues and experimental design of gene association studies显示文摘 | Distefano J K Taverna D M | | 0，，： | 1 |
| 7 | The PYRIN domain: a novel motif found in apoptosis and inflammation proteins显示文摘 | Bertin K DiStefano PS | 2000 | Cell Death Differ2000，7，12： | 1 |
| 8 | Genome wide analysis of hepatic lipid content in extreme obesity显示文摘 | DiStefano J K Kingsley C Craig Wood G | 2014 | Acta Diabetol2014，，： | 1 |
| 9 | Transformational leadership: an examination of cross- national differences and similarities 显示文摘 | Boehnke K Bontis N Joseph J DiStefano | 2003 | Leadership & Organization Development Journal2003，24，1： | 1 |
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