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| 1 | Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension显示文摘AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal hypertension.METHODS:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the study.Liver di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler detection.Cross-section area,portal flow and index of vascular resistance were calculated.In collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were determined.Time-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) administration.RESULTS:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate level.Consequently O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid peroxidation.Increased blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood flow.CONCLUSION:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension. | Andreja Vujanac Vladimir Jakovljevic Dusica Djordjevic Vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric | 2012 | World Journal of Gastroenterology2012，18，4： | 7 |
| 2 | B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors显示文摘The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer therapy.Due to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity.These studies led to new molecular target-driven therapeutic approaches.Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or minimal.This molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these tumors.In addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune response.Accordingly,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer therapy.Finally,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor prognosis.In this review,we summarize the established data from different GIT cancer-related studies and suggest that the B7-H3 molecule could be a promising prognostic biomarker and therapeutic target for anticancer immunotherapy in these tumors. | Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 2 |
| 3 | Mitotic crossover- an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma显示文摘Mitotic crossover is a natural mechanism that is a main source of the genetic variability of primitive organisms.In complex organisms such as mammals,it represents an evolutionary rudiment which persisted as one of the numerous DNA repair mechanisms,and results in the production of homozygous allele combinations in all heterozygous genes located on the chromosome arm distal to the crossover.This event is familiar as loss of heterozygosity,which is one of the key mechanisms responsible for the development and progression of almost all cancers.We propose the hypothesis in which mitotic crossover is a principal source of the increased loss of heterozygosity that leads to the initiation and progression of colorectal carcinoma.The hypothesis could be tested by in vitro inhibition of Rad51 protein,orthotopic grafting of human colon cancer tissue into the gut of mice,and treatment with potential inhibitors.After these procedures,the frequency of mitotic crossover would be estimated.The development of selective inhibitors of mitotic crossover could stop further carcinogenesis of colorectal carcinoma,as well as many other neoplastic events.Loss of heterozygosity is an event responsible for carcinogenesis,its reduction by selective inhibitors of mitotic crossover could have a positive effect on cancer chemoprevention,as well as on growth reduction and a cessation in the progression of earlier developed tumors. | Branislav Rovcanin Ivan Ivanovski Olivera Djuric Dimitrije Nikolic Jelena Petrovic Petar Ivanovski | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 4 | A new approach the arcing faults detection for fast autoreclosure in transmission systems显示文摘 | Djuric M B Terzija V V | 1995 | IEEE Trans on Power Delivery1995，10，4： | 1 |
| 5 | Growth inhabitation of MCF-7 and MCF-10A human breast cells by a-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs 显示文摘 | DJURIC Z HEILBRUN L K LABABIDI S | 1997 | Cancer Letters1997，111，1： | 1 |
| 6 | Gaussian Particle Filter显示文摘 | Kotecha J H Djuric P M | 2003 | IEEE Trans on Signal Processing2003，51，2： | 1 |
| 7 | Dyslocia as a cause of untimely cesarean section显示文摘 | Djuric J A rsenijevic S Bankovic B | 2012 | Vojnosanit Pregl2012，69，7： | 1 |
| 8 | Particle filtering显示文摘 | PETAR M Djuric JAUESH H Kotecha Jianqui Zhang etal | 2003 | IEEE Signal Processing Magazine2003，20，5： | 1 |
| 9 | Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation 显示文摘 | Jelena P Djuric Z Jovanovic M | 2005 | Eur J Drug Metab Pharmacokinet2005，30，12： | 1 |
| 10 | Pathogenesis of pulmonary edema to blast wave显示文摘 | Cernak I Savic J Mrsulja B Djuricic B | 1991 | Vojnosanit Pregl1991，48，6： | 1 |
| 11 | Autonomic nervous system adjustment(ANSA)in patients with hypertension treated with enalapril显示文摘 | Milovanovic B Trifunovic D Djuric D | 2011 | Acta Physiol Hung2011，98，1： | 1 |
| 12 | A search-free DOA estimation algorithm for coprime arrays显示文摘 | Weng Z Y Djuric'P M | 2014 | Digital Signal Process- ing2014，24，： | 1 |
| 13 | Gaussian particle filter显示文摘 | Kotecha J H Djuric P M | 2003 | IEEE Transactions on Signal Processing2003，51，10： | 1 |
| 14 | Arcing faults detection on overhead lines from the voltage signals显示文摘 | Zoric K J Djuric M B Terzija V V | 1997 | Electrical Power & Energy Systems1997，19，5： | 1 |
| 15 | Incidence of radiation myelitis of the cervical spinal cord at doses of 5500 cGy or greater显示文摘 | Jeremic B Djuric L Mijatovic L | | 0，，10： | 1 |
| 16 | An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation 显示文摘 | Parojcic J Ibric S Djuric Z | 2007 | Eur JPharm Sci2007，30，34： | 1 |
| 17 | Age related progressive brachial artery endothelial dysfunction precedes the changed carotid and left ventricular geometry in healthy humans显示文摘 | Djuric D Popovie Z Petrovie J | 1999 | Angiology1999，50，7： | 1 |
| 18 | A new approach to the arcing faults detection for fast autoreclosure in transmission systems 显示文摘 | Djuric M B Terzija V V | 1995 | IEEE Transactions on Power Delivery1995，10，4： | 1 |
| 19 | Effect of soy isofla- vone supplementation on markers of oxidative stress in men and women显示文摘 | DJURIC Z CHEN G DOERGE D R et aI | 2001 | CancerLett2001，172，1： | 1 |
| 20 | Comparison of iron-catalyzed DNA and lipid oxidation 显示文摘 | Djuric Z Potter DW Taffe BG | 2001 | J Biochem Mol Toxicol2001，15，2： | 1 |
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