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| 1 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Donald EL Bonnie H | 2003 | N Eng J Med2003，348，8： | 1 |
| 2 | Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow显示文摘Background:Researchers have explored the use of adipose-derived stem cells(ASCs)as a cellbased therapy to cover wounds in burn patients;however,underlying mechanistic aspects are not completely understood.We hypothesized that ASCs would improve post-burn wound healing after eschar excision and grafting by increasing wound blood flow via induction of angiogenesis-related pathways.Methods:To test the hypothesis,we used an ovine burn model.A 5 cm^(2) full thickness burn wound was induced on each side of the dorsum.After 24 hours,the burned skin was excised and a 2 cm^(2) patch of autologous donor skin was grafted.The wound sites were randomly allocated to either topical application of 7 million allogeneic ASCs or placebo treatment(phosphate-buffered saline[PBS]).Effects of ASCs culture media was also compared to those of PBS.Wound healing was assessed at one and two weeks following the application of ASCs.Allogeneic ASCs were isolated,cultured and characterized from non-injured healthy sheep.The identity of the ASCs was confirmed by flow cytometry analysis,differentiation into multiple lineages and gene expression via real-time polymerase chain reaction.Wound blood flow,epithelialization,graft size and take and the expression of vascular endothelial growth factor(VEGF)were determined via enzyme-linked immunosorbent assay and Western blot.Results:Treatment with ASCs accelerated the patch graft growth compared to the control(p<0.05).Topical application of ASCs significantly increased wound blood flow(p<0.05).Expression of VEGF was significantly higher in the wounds treated with ASCs compared to control(p<0.05).Conclusions:ASCs accelerated grafted skin growth possibly by increasing the blood flow via angiogenesis induced by a VEGF-dependent pathway. | Osamu Fujiwara Anesh Prasai Dannelys Perez-Bello Amina El Ayadi Irene Y.Petrov Rinat O.Esenaliev Yuriy Petrov David N.Herndon Celeste C.Finnerty Donald S.Prough Perenlei Enkhbaatar | 2020 | Burns & Trauma2020，8，1： | 1 |
| 3 | A discrete cell cycle checkpoint in late G,that is cytoskeleton-dependent and MAP kinase (Erk)-independent显示文摘 | Sui H Donald El | 2002 | Experimental Cell Research2002，275，： | 1 |
| 4 | Ma naging acute lower respiratory tract infections in all era of antibacterial resistance显示文摘 | Donald EL Richard A | 2006 | The American Journal of Emergency Medicine2006，24，3： | 1 |
| 5 | Clinical prevalence antimicrobial susceptibility and geographic resistance patterns of Enterococci:results from the SENTRY antimicrobial surveillance program,1997-1999显示文摘 | Donald EL Keller N Barth A | 2001 | Clinical Infections Diseases2001，32，2： | 1 |
| 6 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Susan MP Donald EL Bonnie H | 2003 | BMJ2003，326，： | 1 |
| 7 | Slent thrombosis in the modern era 显示文摘 | Donald EC Donald SB Kalon KLH el al | 2001 | Circulation2001，103，15： | 1 |
| 8 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Susan MP Donald EL Bonnie H | 2003 | NEJM2003，348，： | 1 |
| 9 | Controlling eutrophication: nitrogen andphosphorus 显示文摘 | Daniel JC Hans WP Robert WH Donald FB Sybil PS Karl EH Christiane L Gene EL | 2009 | Science2009，323，20： | 1 |
| 10 | Relaxaiton training reduces symptom reports and acid exposure in gastroesophageal reflux disease patients显示文摘 | Mc Donald Haile J Bradley LA Bailey MA el al | 1994 | Gastroenterology1994，107，： | 1 |
| 11 | Modification of polyvinyl butyral rheological properties via blending with ionomeric polyvinyl butyral显示文摘 | DASGUPTA ARIJIT M DAVID DONALD J el al | 1991 | Poly-mer Bulletin (Berlin)1991，25，6： | 1 |
| 12 | Managing acute lower respiratory tract infections in an era of antibacterial resistance显示文摘 | Gregory AV Donald EL Richard A | 2006 | The American Journal of Emergency Medicine2006，24，3： | 1 |
| 13 | Determinants of mortality and treatment outcome following surgical interventions for acute mesenteric ischemia显示文摘 | Panagiotis Kougias Donald Lau Hosam F. El Sayed Wei Zhou Tam T. Huynh Peter H. Lin | 2007 | Journal of Vascular Surgery2007，，3： | 1 |
| 14 | Curcumin,a dietary component,has anticancer,chemosensitization, and radiosensitization effects by down- regulating the MDM2 oncogene through the Pi3K/mTOR/ETS2 path- ways显示文摘 | Li M Zhang Z Donald L el al | 2007 | Cancer Res2007，67，5： | 1 |
| 15 | Managing acute lower respiratory tract infections in an era of antibacterial resistance 显示文摘 | Gregory AV Donald EL Richard A | 2006 | The American Journal of Emergency Medicine2006，24，3： | 1 |
| 16 | Antimicrobial suscepti- bility among organisms from the Asia Rim, Europe and Latin and North America collected as part of TEST and in vitro activity of tigecycline 显示文摘 | Reiuert R Donald EL Rosi FX et d | 2007 | JMicrob Chemather2007，60，6： | 1 |
| 17 | Identification of severe acute respiratory sndrome in Canada显示文摘 | Donald EL Bonnie H | 2003 | N Eng J Med2003，348，： | 1 |
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