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| 1 | Amyloid and tau positive mild cognitive impairment:clinical and biomarker characteristics of dementia progression显示文摘Background:According to the amyloid,tau,neurodegeneration research framework classification,amyloid and tau positive(A+T+)mild cognitive impairment(MCI)individuals are defined as prodromal Alzheimer disease.This study was designed to compare the clinical and biomarker features between A+T+MCI individuals who progressed to progressive MCI(pMCI)and those who remained stable MCI(sMCI),and to identify relevant baseline clinical biomarker and features that could be used to predict progression to dementia within 2 years.Methods:We stratified 197 A+T+MCI individuals into pMCI(n=64)and sMCI(n=133)over 2 years.Demographics and cognitive assessment scores,cerebrospinal fluid(CSF),and neuroimaging biomarkers(18F-florbetapir positron emission tomography mean standardized uptake value ratios[SUVR]and structural magnetic resonance imaging[MRI])were compared between pMCI and sMCI at baseline,12-and 24-month follow-up.Logistic regression models then were used to evaluate clinical baseline and biomarker features that predicted dementia progression in A+T+MCI.Results:pMCI individuals had higher mean 18F-florbetapir SUVR,CSF total-tau(t-tau),and p-tau181P than those in sMCI individuals.pMCI individuals performed poorer in cognitive assessments,both global and domain specific(memory,executive,language,attention,and visuospatial skills)than sMCI.At baseline,there were significant differences in regions of interest of structural MRI between the two groups,including bilateral amygdala,hippocampus and entorhinal,bilateral inferior lateral ventricle,left superior and middle temporal,left posterior and caudal anterior cingulate(P<0.05).Baseline CSF t-tau levels and cognitive scores of Montreal cognitive assessment,functional assessment questionnaire,and everyday cognition by the patient’s study partner language domain could predict progression to dementia in A+T+MCI within 2 years.Conclusions:In future clinical trials,specific CSF and cognitive measures that predict dementia progression in A+T+MCI might be useful risk factors for assessing the risk of dementia progression. | Hong-Chun Wei Bing Li Kok Pin Ng Qing-Xi Fu Sheng-Jie Dong Mao-Wen Ba Min Kong | 2021 | Chinese Medical Journal2021，，14： | 3 |
| 2 | 2D materials for conducting holes from grain boundaries in perovskite solar cells显示文摘Grain boundaries in organic-inorganic halide perovskite solar cells(PSCs)have been found to be detrimental to the photovoltaic performance of devices.Here,we develop a unique approach to overcome this problem by modifying the edges of perovskite grain boundaries with flakes of high-mobility two-dimensional(2D)materials via a convenient solution process.A synergistic effect between the 2D flakes and perovskite grain boundaries is observed for the first time,which can significantly enhance the performance of PSCs.We find that the 2D flakes can conduct holes from the grain boundaries to the hole transport layers in PSCs,thereby making hole channels in the grain boundaries of the devices.Hence,2D flakes with high carrier mobilities and short distances to grain boundaries can induce a more pronounced performance enhancement of the devices.This work presents a cost-effective strategy for improving the performance of PSCs by using high-mobility 2D materials. | Peng You Guanqi Tang Jiupeng Cao Dong Shen Tsz-Wai Ng Zafer Hawash Naixiang Wang Chun-Ki Liu Wei Lu Qidong Tai Yabing Qi Chun-Sing Lee Feng Yan | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 3 | Tumor Suppressor Functions of miR-133a in Colorectal Cancer显示文摘 | Yujuan Dong Junhong Zhao Chung-Wah Wu Lijing Zhang Xiaodong Liu Wei Kang Wing-Wah Leung Ning Zhang Francis K.L. Chan Joseph J.Y. Sung Simon S.M. Ng Jun Yu | 2013 | Molecular Cancer Research2013，，9： | 3 |
| 4 | Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Xinyu Zhou Jianjun Chen Qi Li Gaoping Ren Guoen Yao Ming Liu Qiang Dong Jìng Guo Leilei Li Jing Guo Peng Xie | 2012 | Stroke2012，，11： | 2 |
| 5 | α-Kirilowin,a novel rib- osome-inactivating protein from seeds of Trichosanthes kirilowii (family Cucurbitaccac):A comparison with betakirilo Win and other related proteins显示文摘 | Wong R N Dong T X Ng T B | 1996 | Int J Pept Protein Res1996，47，12： | 1 |
| 6 | Isolation and cha- racterization of a novel ribosome--inactivating protein,beta-ki- rilowin,from the seeds of Triehosanthes' kirilowii显示文摘 | Dong TX Ng T B Yeung H W Wong R N | 1994 | Biochem Biophys Res Commun1994，199，1： | 1 |
| 7 | Difference in expression level and localization of DNA polymerase beta among human esophageal cancer focus,adjacent and corresponding normal tissues显示文摘 | Dong ZM Zheng NG Wu JL | 2006 | Dis Esophagus2006，19，3： | 1 |
| 8 | Intracellular effects of prodrug-like wortmannin probes显示文摘Wortmannin, a known inhibitor of phosphoinositide 3-kinases(PI3 Ks), their low selectivity and high toxicity is still problematic and less is known about their effects on PI3 Ks in cellular systems. Hence, we have synthesized a series of multifunctional wortmannin probes with the ability to self-activate, by installing a clickable handle at C11 site, and secondary amine and cancer-targeting moiety at C20 site respectively. MTT assay first confirmed that self-activating probes have better inhibition potency and biotin enhanced their cancer cell uptake. Further experiments showed most of probes can target PI3 K/Akt/mTOR pathway with prolonged turn-over time. Protein profiling and pull-down results were observed that the derivatives not only labelled four PI3 Ks with selectivity, but also engaged in covalent interactions with numerous cellular proteins which could be the major reason of their high toxicity. | Shasha Ying Shubo Du Jia Dong Bi Xuan Ng Chengwu Zhang Lin Li Jingyan Ge Qing Zhua | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 9 | Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Thl-adjuvanted poly- peptides followed by defective alpha viral particles express- ing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5显示文摘 | Lin Y Kwon T Polo J Zhu YF Coates S Crawford K Dong C Wininger M Hall J Selby M Coit D Medina- Selby A McCoin C Ng P Drane D Chien D Han J Va- jdy M Houghton M | 2008 | J Virol2008，82，15： | 1 |
| 10 | High IL-35 Pleur&l Expression in P&tients with Tuberculous Pleur&l Effusion显示文摘 | Dong X Y&ng J | 2015 | Med 8ci Monit2015，2，： | 1 |
| 11 | Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectalcancer and polyps显示文摘 | Wu CW Ng SS Dong YJ | 2012 | Gut2012，61，5： | 1 |
| 12 | Preparation and physicochemical characterization of trans-resveratrol nanoparticles by temperature-controlled antisoIvent precipitation显示文摘 | Kim S Ng W K Dong Y Das S Tan R B H | 2012 | Journal of Food Engineering2012，108，1： | 1 |
| 13 | MicroRNA dysregnlation as a prognostic bio- marker in colorectal cancer显示文摘 | Dong Y YuJ Ng SS | 2014 | Cancer Manag Res2014，6，： | 1 |
| 14 | Scalable ionic gelation syn- thesis of chitosan nanoparticles for drug delivery in static mix- ers显示文摘 | Dong Y Ng WK Shen S | 2013 | Carbohydrate Polymers2013，94，2： | 1 |
| 15 | Development of a p roduct configuration system with an ontology based approach 显示文摘 | YANG Dong D()NG Ming MIAO Rui | 2008 | Computer Aided Design2008，10，8： | 1 |
| 16 | Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps显示文摘 | Wu CW Ng SS Dong YJ | 2012 | Gut2012，61，5： | 1 |
| 17 | Evaluation of a novel tetra-functional branched poly (ethylene glycol) crosslinker for manufacture of crosslinked,decellularized,porcine aortic valve leaflets显示文摘 | Hu X J Dong NG Shi JW | 2014 | J Biomed Mater Res B Appl Biomater2014，102，2： | 1 |
| 18 | Identification of microRNA- 135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma显示文摘 | Wu CW Ng SC Dong Y | 2014 | Clin Cancer Res2014，20，11： | 1 |
| 19 | Identification of microRNA-135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma显示文摘 | Wu C W Ng S C Dong Y | 2014 | Clin Cancer Res2014，20，11： | 1 |
| 20 | Detection of miR-92c~ and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps 显示文摘 | Wu CW Ng SS Dong YJ | 2012 | Gut2012，61，5： | 1 |
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