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| 1 | 婴幼儿卒中的处理:来自美国心脏协会卒中委员会和青少年心血管病委员会专门写作组的科学声明显示文摘目的:本声明旨在回顾有关儿童卒中的文献,为最佳的诊断和治疗提供推荐意见,供负责诊断和治疗婴儿、儿童和青少年脑血管病的医生使用。方法:写作组成员由美国心脏协会卒中委员会科学声明监督委员会任命,由多个不同领域的专家组成。应用美国心脏协会卒中委员会的证据分级标准对每条推荐意见进行分级。在经过小组成员审查后,草稿由4位同行评议专家和卒中委员会指导委员会成员审阅,并由美国心脏协会科学咨询和协调委员会批准。我们预计该声明需在4年内进行更新。结果:为镰状细胞病、烟雾病、颈一脑动脉夹层分离和心源性栓塞引起的缺血性卒中的预防提供循证推荐,同时为出血性卒中的评价和处理提供推荐意见。提出儿童使用肝素和华法林的剂量方案。另外,还为围产期卒中和儿童脑静脉窦血栓形成的评价和处理提供推荐。 | E.Steve Roach(著) Meredith R. Golomb(著) Robert Adams(著) Jose Biller(著) Stephen Daniels(著) Gabrielle deVeber(著) Donna Ferriero(著) Blaise V. Jones(著) Fenella J. Kirkham(著) R. Michael Scott(著) Edward R. Smith(著) 刘丽芳(译) 王胜男(译) 王伟(译) 林镇洲(译) 朱佳佳(译) 潘速跃(译) | 2008 | 国际脑血管病杂志2008，16，11： | 60 |
| 2 | Outpatient Laparoscopic Cholecystectomy: Patient Outcomes After Implementation of a Clinical Pathway显示文摘 | J. Forrest Calland Koji Tanaka Eugene Foley Viktor E. Bovbjerg Donna W. Markey Sonia Blome John S. Minasi John B. Hanks Marcia M. Moore Jeffery S. Young R. Scott Jones Bruce D. Schirmer Reid B. Adams | 2001 | Annals of Surgery2001，，5： | 1 |
| 3 | Patterns and Predictors of Fast Food Consumption After Acute Myocardial Infarction显示文摘 | Adam C. Salisbury Paul S. Chan Kensey L. Gosch Donna M. Buchanan John A. Spertus | 2011 | The American Journal of Cardiology2011，，8： | 1 |
| 4 | Arsenic Requires Sphingosine-1-Phosphate Type 1 Receptors to Induce Angiogenic Genes and Endothelial Cell Remodeling显示文摘 | Adam C. Straub Linda R. Klei Donna B. Stolz Aaron Barchowsky | 2009 | The American Journal of Pathology2009，，5： | 1 |
| 5 | Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide显示文摘 | Straub Adam C Clark Katherine A Ross Mark A Chandra Ashwin G Li Song Gao Xiang Pagano Patrick J Stolz Donna B Barchowsky Aaron | 2008 | Journal of Clinical Investigation2008，，12： | 1 |
| 6 | Parental Assessment of Executive Function and Internalizing and Externalizing Behavior in Primary Hypertension after Anti-Hypertensive Therapy显示文摘 | Marc B. Lande Heather Adams Bonita Falkner Shari R. Waldstein George J. Schwartz Peter G. Szilagyi Hongyue Wang Donna Palumbo | 2010 | The Journal of Pediatrics2010，，1： | 1 |
| 7 | Hydration effects on cognitive performance during military tasks in temperate and cold environments显示文摘 | Gina E. Adam Robert Carter Samuel N. Cheuvront Donna J. Merullo John W. Castellani Harris R. Lieberman Michael N. Sawka | 2007 | Physiology & Behavior2007，，4： | 1 |
| 8 | Initial experience with an intravenous P2Y 12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial显示文摘 | Adam B. Greenbaum Cindy L. Grines John A. Bittl Richard C. Becker Dean J. Kereiakes Ian C. Gilchrist Jane Clegg Jill E. Stankowski Donna R. Grogan Robert A. Harrington Hakan Emanuelsson W. Douglas Weaver | 2006 | American Heart Journal2006，，3： | 1 |
| 9 | Professionalism in nursing behaviom of nurse practitioners显示文摘 | Donna Adams Barbara K Miller | 2001 | Journal of Professional Nursing2001，17，4： | 1 |
| 10 | The Relation of FIMR Programs and Other Perinatal Systems Initiatives with Maternal and Child Health Activities in the Community显示文摘 | Donna M. Strobino Katherine M. Baldwin Holly Grason Dawn P. Misra Karen A. McDonnell Mira Liao Adam A. Allston | 2004 | Maternal and Child Health Journal2004，，4： | 1 |
| 11 | Combination tramadol plus acetaminophen for postsurgical pain显示文摘 | Adam B Smith Thanjavur S Ravikumar Marc Kamin Donna Jordan Jim Xiang Norman Rosenthal | 2004 | The American Journal of Surgery2004，，4： | 1 |
| 12 | Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product显示文摘We have previously described a novel artificial NFEVβ-secretase(BACE1)cleavage site,which when introduced into the amyloid-βprecursor protein(APP),significantly enhances APP cleavage by BACE1 in in vitro and cellular assays.In this study,we describe the identification and characterization of a single chain fragment of variable region(scFv),specific to the EV neo-epitope derived from BACE1 cleavage of the NFEV-containing peptide,and its conversion to IgG1.Both the scFv displayed on phage and EV-IgG1 show exquisite specificity for binding to the EV neoepitope without cross-reactivity to other NFEV containing peptides or WT-APP KMDA cleavage products.EV-IgG1 can detect as little as 0.3 nmol/L of the EV peptide.EV-IgG1 antibody was purified,conjugated with alkaline phosphatase and utilized in various biological assays.In the BACE1 enzymatic assay using NFEV substrate,a BACE1 inhibitor MRK-3 inhibited cleavage with an IC50 of 2.4 nmol/L with excellent reproducibility.In an APP_NFEV stable SH-SY5Y cellular assay,the EC_(50) for inhibition of EV-Aβ peptide secretion with MRK-3 was 236 nmol/L,consistent with values derived using an EV polyclonal antibody.In an APP_NFEV knock-in mouse model,both Aβ_EV40 and Aβ_EV42 peptides in brain homogenate showed excellent gene dosage dependence.In conclusion,the EV neoepitope specific monoclonal antibody is a novel reagent for BACE1 inhibitor discovery for both in vitro,cellular screening assays and in vivo biochemical studies.The methods described herein are generally applicable to novel synthetic substrates and enzyme targets to enable robust screening platforms for enzyme inhibitors. | Guoxin Wu Sethu Sankaranarayanan Donna L.Montgomery Adam J.Simon Zhiqiang An Mary J.Savage | 2011 | Protein & Cell2011，2，7： | 0 |
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