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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Strategic Implementation as a Core Competency: The5P' s Model 显示文摘 | MILDRED G P DONNA A LESLIE A T JOHN H H | 2007 | Jour- nal of Management Research2007，，7： | 1 |
| 4 | Marketing in hypermedia computer-mediated environments: con- ceptual foundations 显示文摘 | Hoffman Donna L Novak Thomas P | 1996 | Journal of Marketing1996，60，3： | 1 |
| 5 | Adverse effects of semen processing on human spem DNA integrity显示文摘 | Victor M Keith J Donna P | 1999 | J Urol1999，161，282： | 1 |
| 6 | Current Issues and Conceptualizations of Service Quality in the Recreation Sport Industry显示文摘 | Yong J K Donna L P | 2004 | Sport Marketing Quarterly2004，13，3： | 1 |
| 7 | Triazine Herbicides and Overian Epithelial Neoplasms显示文摘 | Donna A Crosignani P Robutti F | 1989 | Scand J Work Environ Health1989，15，： | 1 |
| 8 | Marketing in hypermedia computer-mediated environments: Conceptual foundations 显示文摘 | Donna L Hoffman and Thomas P Novak | 1996 | Journal of Marketing1996，60，3： | 1 |
| 9 | Measuring the customer experience in online environments: A structural modeling approach显示文摘 | Thomas P Novak Donna L Hoffman and Yiu-Fai Yung | 2000 | Marketing Science2000，19，1： | 1 |
| 10 | Making space for time:issues in space-time data representation显示文摘 | DONNA J P | 2001 | Geolnformatiea2001，5，1： | 1 |
| 11 | Flow online: Lessons learned and future prospects显示文摘 | Donna L Hoffman and Thomas P Novak | 2009 | Journal of Interactive Marketing2009，23，1： | 1 |
| 12 | Adverse effect of semen processing on human sperm DNA integrity显示文摘 | Victor M Keith J Donna P | 1999 | J Urol1999，，： | 1 |
| 13 | Current Issues and Conceptualizations of Service Quality in the Recreation Sport Industry显示文摘 | Yong J K Donna L P | 2004 | Sport Marketing Quarter- ly2004，13，3： | 1 |
| 14 | Developing an educated citizenry: the undergraduate public health learning outcomes project显示文摘 | DONNA J P SUSAN A CHRISTINE M P et 81 | 2013 | Public Health Reports2013，128，： | 1 |
| 15 | Effects of vasoactivepeptides on cytosolic calcium in cultured mesangial cells 显示文摘 | Aviv H Nanni P Donna G | 1986 | Am J Physiol1986，251，： | 1 |
| 16 | Stable isotope composition of walleye: ^15N accumulation with age and area-specific differences in δ^13 C 显示文摘 | NATHANAEL C O DONNA L P | 2001 | Can J Fish Aquat Sci2001，58，： | 1 |
| 17 | A controlled comparison of traditional feeding tube verification methods to a bedside,electromagnetic technique显示文摘 | Keams P J Donna C | 2001 | J Parenter Nutr2001，25，： | 1 |
| 18 | Comparing science efficacy beliefs of elementary education majors in integrated and non-integrated teacher education coursework显示文摘 | Kenneth P K Donna L W | | 0，，02： | 1 |
| 19 | Current issues and conceptualizations of service quality in the recreation sport industry显示文摘 | YONG J K DONNA L P | 2004 | Sport Mark Q2004，13，3： | 1 |
| 20 | The Hazards of Moist Toilet Paper Allergy to the Preservative Methylchloroisothiazolinone/Methylisothiazolinone显示文摘 | Kevin H Gardner Mark D P Davis MD Donna M Richardson RN | 2010 | ARCH D ER-MATOL2010，8，： | 1 |
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