|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Syringomyelia associated with cervical spondylosis: A rare condition显示文摘Spinal spondylosis is an extremely common condition that has only rarely been described as a cause of syringomyelia. We describe a case of syringomyelia associated with cervical spondylosis admitted at our division and treated by our institute. It is the case of a 66-yearold woman. At our observation she was affected by moderate-severe spastic tetraparesis. T2-weighted magnetic resonance imaging(MRI) showed an hyperintense signal within spinal cord from C3 to T1 with a more sharply defined process in the inferior cervical spinal cord. At the same level bulging discs, facets and ligamenta flava hypertrophy determined a compression towards subarachnoid space and spinal cord. Spinal cord compression was more evident in hyperextension rather than flexion. A 4-level laminectomy and subsequent posterior stabilization with intra-articular screws was executed. At 3-mo follow up there was a regression of tetraparesis but motor deficits of the lower limbs residuated. At the same follow up postoperative MRI was executed. It suggested enlargement of the syrinx. Perhaps hyperintensity within spinal cord appeared 'bounded' from C3 to C7 with clearer margins. At the level of surgical decompression, subarachnoid space and spinal cord enlargement were also evident. A review of the literature was executed using Pub Med database. The objective of the research was to find an etiopathological theory able to relate syringomyelia with cervical spondylosis. Only 6 articles have been found. At the origin of syringomyelia the mechanisms of compression and instability are proposed. Perhaps other studies assert the importance of subarachnoid space regard cerebrospinal fluid(CSF) dynamic. We postulate that cervical spine instability may be the cause of multiple microtrauma towards spinal cord and consequently may damage spinal cord parenchyma generating myelomalacia and consequently syrinx. Otherwise the hemorrhage within spinal cord central canal can cause an obstruction of CSF outflow, finally generating the syrinx. On the other hand in cervical spondylosis the stenotic elements can affect subarachnoid space. These elements rubbing towards spinal cord during movements of the neck can generate arachnoiditis, subarachnoid hemorrhages and arachnoid adhesions. Analyzing the literature these 'complications' of cervical spondylosis are described at the origin of syringomyelia. So surgical decompression, enlarging medullary canal prevents rubbings and contacts between the bone-ligament structures of the spine towards spinal cord and subarachnoid space therefore syringomyelia. Perhaps stabilization is also necessary to prevent instability of the cervical spine at the base of central cord syndrome or syringomyelia. Finally although patients affected by central cord syndrome are usually managed conservatively we advocate, also for them, surgical treatment in cases affected by advanced state of the symptoms and MRI. | Alessandro Landi Lorenzo Nigro Nicola Marotta Cristina Mancarella Pasquale Donnarumma Roberto Delfini | 2013 | World Journal of Clinical Cases2013，1，3： | 7 |
| 2 | 人类角质形成细胞中调节细胞内信号传导的Toll样受体(TLR2)对糠秕马拉色菌的反应显示文摘Toll-like receptors (TLRs) are crucial players in the innate immune response to microbial invaders. The lipophilic yeast Malassezia furfur has been implicated in the triggering of scalp lesions in psoriasis. The aim of the present study was to assess the role of TLRs in the defence against M. furfur infection. The expression of the myeloid differentiation factor 88 (MyD88) gene, which is involved in the signalling pathway of many TLRs, was also analysed. In addition, a possible correlation of antimicrobial peptides of the β -defensin family to TLRs was tested. Human keratinocytes infected with M. furfur and a variety oiM. furfur-positive psoriatic skin biopsies were analysed by RT-PCR, for TLRs, MyD88, human β -defensin 2 (HBD- 2), HBD- 3 and interleukin- 8 (IL- 8) mRNA expression. When keratinocytes were infected with M. furfur, an up-regulation for TLR2, MyD88, HBD- 2, HBD- 3 and IL- 8 mRNA was demonstrated, compared to the untreated cells. The same results were obtained when psoriatic skin biopsies were analysed. The M. furfur-induced increase in HBD- 2 and IL- 8 gene expression is inhibited by anti-TLR2 neutralising antibodies, suggesting that TLR2 is involved in the M. furfur-induced expression of these molecules. These findings suggest the importance of TLRs in skin protection against fungi and the importance of keratinocytes as a component of innate immunity. | Baroni A. Orlando M. Donnarumma G. M.A. Tufano 刘艳 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，3： | 4 |
| 3 | Sustained virological response: A milestone in the treatment of chronic hepatitis C显示文摘AIM: To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response. METHODS: One hundred and fifty subjects with chronic hepatitis C (CHC) or cirrhosis and sustained virological response (SVR) between the years of 1989 and 2008 were enrolled in a long-term clinical follow-up study at the Gastrointestinal and Liver Unit of the University Hospital of Naples 'Federico Ⅱ'. At the beginning of the study, the diagnosis of HCV infection was made on the basis of serum positivity for antibodies to HCV and detection of HCV RNA transcripts, while a diagnosis of chronic hepatitis was formulated using imaging techniques and/or a liver biopsy. SVR was achieved by interferon-based therapy, both conventional and pegylated, with and without ribavirin treatment. The patients were evaluated for follow-up at a median length of 8.6 years, but ranged from 2-19.9 years. Among them, 137 patients had pre-treatment CHC and 13 had cirrhosis. The patients were followed with clinical, biochemical, virological, and ultrasound assessments on a given schedule. Finally, a group of 27 patients underwent a liver biopsy at the beginning of the study and transient elastography at their final visit to evaluate changes in liver fibrosis. RESULTS: The median follow-up was 8.6 years (range 2-19.9 years). HCV RNA remained undetectable in all patients, even in patients who eventually developed liver-related complications, indicating no risk of HCV recurrence. Three liver-related complications were observed: two cases of hepatocellular carcinoma and one case of bleeding from esophageal varices resulting in an incidence rate of 0.23%/person per year. Further, all three complications took place in patients diagnosed with cirrhosis before treatment began. Only one death due to liver-related causes occurred, resulting in a mortality rate of 0.077% person per year. This amounts to a 99.33% survival rate in our cohort of patients after therapy for HCV infection. Finally, of the 27 patients who underwent a liver biopsy at the beginning of the study, a reduction in liver fibrosis was observed in 70.3% of the cases; only three cases registering values of liver stiffness indicative of significant fibrosis. CONCLUSION: Patients with CHC and SVR show an excellent prognosis with no risk of recurrence and a very low rate of mortality. Our data indicate that viruseradication following interferon treatment can last up to 20 years. | Filomena Morisco Rocco Granata Tommaso Stroffolini Maria Guarino Laura Donnarumma Laura Gaeta Ilaria Loperto Ivan Gentile Francesco Auriemma Nicola Caporaso | 2013 | World Journal of Gastroenterology2013，19，18： | 4 |
| 4 | Clinical-radio-graphic correlations within the first five hours of cerebral infaction显示文摘 | Zito JL Donnarumma R | 1992 | Acta Neurol Scand1992，86，： | 1 |
| 5 | Clinical radiographic correlations within the first five hours of cerebral infarction 显示文摘 | Horowitz SH Zito JL Donnarumma R | 1992 | Acta Neurol Scand1992，86，2： | 1 |
| 6 | Malassezia furfur induces the expression of β-defensin-2 in human keratino-cytes in a protein kinase C-dependent mannerP 显示文摘 | Donnarumma G Paoletti I Buommino E | 2004 | Arch Dermatol Res2004，295，： | 1 |
| 7 | Protocatechuic acid is the major human metabolite of cyanidin-glucosides显示文摘 | Vitaglione P Donnarumma G Napolitano A | | 0，，： | 1 |
| 8 | Toll-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia fur- fur 显示文摘 | Baroni A Orlando M Donnarumma G | 2006 | Arch Dermatol Res2006，297，： | 1 |
| 9 | Incidence of anti-Helicobter pylori and anti-CagA antibodies in rosacea patients显示文摘 | Argenziano G Donnarumma G Iovene MR | 2003 | International Journal of Dermatology2003，42，8： | 1 |
| 10 | Toil-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia furfur 显示文摘 | Baroni A Orlando M Donnarumma G | 2006 | Arch Dermatol Res2006，297，： | 1 |
| 11 | Antimicrobial human beta-defensin-2 stimulates migration, proliferation and tube formation of human umbilical vein endothelial cells显示文摘 | Baroni A Donnarumma G Paoletti I | 2009 | Peptides2009，30，2： | 1 |
| 12 | Incidence of anti-Helicobacter pylori and anti-CagA antibodies in rosacea patients显示文摘 | Argenziano G Donnarumma G Iovene MR | 2003 | Int J Dermatol2003，42，3： | 1 |
| 13 | Nitrite Therapy Ameliorates Myocardial Injury via H2S and Nu- clear Factor-Erythroid 2-Related Factor 2 ( Nrf2 )-De- pendent Signaling in Chronic Heart Failure 显示文摘 | Islam K N Donnarumma E Bhushan S | 2015 | Circula- tion Research2015，117，： | 1 |
| 14 | Incidence of anti-Helicobacter pylori and anti-CagA antibodies in roeacea patients显示文摘 | ARGENZIANO G DONNARUMMA G IOVENE MR | 2003 | Int J Dermatol2003，42，8： | 1 |
| 15 | Antimierobial human beta-defensin-2 stimulates migration, proliferation and tube formation of human umbilical vein endothelial cells显示文摘 | Baroni A Donnarumma G Paoletti I | 2009 | Peptides2009，30，2： | 1 |
| 16 | Antimicrobial human beta-defensin-2 stimulates migration, proliferation and tube formation of human umbilical vein endothelial cells显示文摘 | Baroni A Donnarumma G Paoletti I | 2009 | Peptides2009，30，2： | 1 |
| 17 | Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes显示文摘 | Ciferri C Chandramouli S Donnarumma D Nikitin P A Cianfrocco M A Gerrein R Feire A L Barnett S W Lilja A E Rappuoli R | 2015 | Proc Natl Acad Sci2015，，20： | 1 |
| 18 | Incidenceofanti2 Heli2 cobacter pylori and anti CagA antibodies in rosacea patients显示文摘 | Argenziano G Donnarumma G Iovene MR | 2003 | Int J Dermatol2003，42，8： | 1 |
| 19 | Posterolateral arthro- desis in lumbar spine surgery using autologous platelet-rich plasma and cancellous bone substitute: an osteoinductive and osteoconducfive effect显示文摘 | Tarantino R Donnarumma P Mancarella C | 2014 | Global Spine J2014，4，3： | 1 |
| 20 | Posterolateral arthro- desis in lumbar spine surgery using autologous platelet-rich plasma and cancellous bone substitute: an osteoinductive and osteoconductive effect显示文摘 | Tarantino R Donnarumma P Mancarella C | 2014 | Global Spine J2014，4，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员