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| 1 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 2 | Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease显示文摘 | O'Donnell DE Lam M Webb KA | 1998 | Am J Respir Grit Care Med1998，158，51： | 1 |
| 3 | Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease 显示文摘 | O'Donnell DE Revill SM Webb KA | 2001 | Am J Respir Crit Care Med2001，164，5： | 1 |
| 4 | Effects of tiotropium on lung hyperinflation dyspnoea and exercise tolerance in COPD显示文摘 | O'Donnell DE Fluge T Gerken F | 2004 | Eur Respir J2004，23，6： | 1 |
| 5 | Effects of tiotropioum on lung hyperinflation, dyspnoea and exercise tolerance in COPD显示文摘 | O'Donnell DE Fluge T Gerken F | 2004 | Eur Respir J2004，23，6： | 1 |
| 6 | Canadian Thoracic societyrecommendations for management of Chronic obstructive Pulmonary dis-ease显示文摘 | Donnell DE Aaron S Bourbeau J et aJ | 2003 | Can respir J2003，10，： | 1 |
| 7 | Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation显示文摘 | Newton M O'Donnell DE Forkert L | 2002 | Chest2002，121，4： | 1 |
| 8 | Urbaniza-tion and the spread of diseases of affluence in China显示文摘 | Van de Poel E O'Donnell O Van Doorslaer E | 2009 | Econ Hum Biol2009，7，2： | 1 |
| 9 | State of the Art Corn pendium: Canadian Thoracic Society recommendations for the management of chronic obstructive pulmonary disease显示文摘 | O'Donnell DE Aaron S Bourbeau J | 2004 | Can Re spir J2004，1，： | 1 |
| 10 | Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease 显示文摘 | O' Donnell DE Revill SM Webb KA | 2001 | Am J Respir Crit Care Med2001，164，： | 1 |
| 11 | Effect of fluticasone propionate/salmeterol on lung hyperintlation and exercise endurance in C OPD 显示文摘 | O'Donnell DE Sciurba F Celli B | 2006 | Chest2006，130，3： | 1 |
| 12 | Dynamic hyperimflation and exercise intolerance in chronic obstructive pulmonary disease显示文摘 | O'Donnell DE Revill SW Webb KA | 2001 | Am J Respir Crit Care Med2001，164，5： | 1 |
| 13 | Effects of tiotropium on lung hy-perinflation ,dyspnea,and exercise tolerance in patients with COPD显示文摘 | Donnell DE Fluge T Gerken F | 2004 | Eur Respir J2004，23，6： | 1 |
| 14 | Immunotherapy of Experimental Bladder Cancer with Recombinant BCG Expressing Interferon-gamma显示文摘 | Arnold J De Boer EC O'Donnell MA | 2004 | J Immunother2004，27，2： | 1 |
| 15 | Sensory mechanical relationships during high intensity,constant-work-rate exercise in COPD显示文摘 | O'Donnell DE Hamilton AL Webb KA | | 0，，： | 1 |
| 16 | An inte- grated procedure for the extraction of bacterial isoprenoid quinones and polar lipids显示文摘 | Minnikin DE O'Donnell AG Goodfellow | 1984 | J Microbiol Methods1984，2，5： | 1 |
| 17 | Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease 2008 update highlights for primary care显示文摘 | O'Donnell DE Hernandez P Kaplan A | 2008 | Can Respir J2008，15，： | 1 |
| 18 | Antibodies against merozoite surface protein (MSP)-1 (19) are a major component of the invasion-inhibitory response in individuals immune to malaria显示文摘 | O'Donnell RA de Koning-Ward TF Burt RA | 2001 | J Exp Med2001，193，12： | 1 |
| 19 | Effects of tiotropium on lung hyperinflation, dyspnea and exercise tolerance in COPD 显示文摘 | O' Donnell DE Fluge T Gerken F | 2004 | Eur Respir J2004，23，： | 1 |
| 20 | Effects of hy- peroxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease显示文摘 | O' Donnell DE D' Arsigny C Webb KA | 2001 | Am J Respir Crit Care Med2001，16，： | 1 |
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