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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | 澳大利亚人乳头状瘤病毒疫苗计划实施5年对年轻人群生殖器疣患病情况的影响:国家调查数据分析显示文摘目的评估2007年中开始的澳大利亚人乳头状瘤病毒(HPV)疫苗计划对生殖器疣患病情况的影响。设计国家调查数据趋势分析。数据来源数据收集于2004--2011年度澳大利亚8所性健康服务机构;其中2所最大的临床中心收集了自我报告的本中心2009年度HPV疫苗现状。研究对象2004--2011年度首次就诊的85770名澳大利亚出生的国民;其中7686(9.0%)名患生殖器疣。主要结局测量比较前疫苗时期(2004—2007年中)和疫苗时期(2007年中-2001年末)不同人群生殖器疣新发病率变化趋势。结果疫苗时期21岁以下和21~30岁女性诊断患有生殖器疣的比例明显下降,发病率分别从2007年度的11.5%和11.3%下降至2011年度的0.85%和3.1%,P均〈0.001。在30岁以上的女性中未发现发病率的明显下降。在21岁以下和21~30岁异性恋男性人群中疫苗时期生殖器疣的发病率较前疫苗时期明显下降,分别由2007年度12.1%和18.2%下降至2011年度2.2%和8.9%,P均〈0.001。30岁以上的异性恋男性人群中发病率无明显下降。2011年235名21岁以下女性在使用HPV疫苗后无新发生殖器疣病例。结论年轻女性生殖器疣发病率的显著下降和2011年度部分年轻女性使用疫苗后的零发病率,说明HPV疫苗获得实验室外的良好功效。异性恋男性生殖器疣发病率的显著下降可能是由于群体免疫所致。 | Hammad Ali,lecturer Basil Donovan, professor HandanWand,senior lecturer Tim R H Read, sexual health physician David G Regan,senior lecturer Andrew E Grulich, professor Christopher K FaMey, professor Rebecca J Guy, associate professor 尹婕(译) 潘凌亚(校) | 2013 | 英国医学杂志中文版2013，16，4： | 4 |
| 3 | Cryopreservation of eguine embryos by open pulled straw, cryoloop, or conventional slow cooling methods显示文摘 | Oberstein N O Donovan M K Bruemmer J E | 2001 | Theriogenology2001，55，： | 2 |
| 4 | Adaptability in the workplace: Development of a taxonomy of adaptive performance 显示文摘 | PulakosED Arad S Donovan M A Plamondon K E | 2000 | Journal of Applied Psychology2000，85，： | 1 |
| 5 | Morphological phy- logenetics of termites (Isoptera) 显示文摘 | Donovan S E Jones D T Sands W A | 2000 | Biological Journal of the Linnean Society2000，70，3： | 1 |
| 6 | Phosphorus retention and sorption by constructed wetland soils in South- east Ireland显示文摘 | DUNNE E J CULLETON N O'DONOVAN G | 2005 | Water Research2005，39，18： | 1 |
| 7 | Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge显示文摘 | Donovan E L McCord J M Reuland D J | 2012 | Oxid Med Cell Longev2012，2012，13： | 1 |
| 8 | Comparison of trends in prostate cancer mortality in England and Wales and the USA显示文摘 | Oliver E GunneU D Donovan JL | 2000 | Lancet2000，355，6： | 1 |
| 9 | Efficient soybean transformation using hygromycin B selection in the cotyledonarynode method显示文摘 | Olhoft P M Flagel L E Donovan C M | 2003 | Planta2003，216，5： | 1 |
| 10 | Effect of salinity on grain yield and quality, vegetative growth and germination of emidwarf and durum wheat显示文摘 | Francois L E Maas E V Donovan T J | 1986 | Agronomy Journal1986，78，6： | 1 |
| 11 | Efficient soybean transformation using hygromycin B selection in the cotyledonarynode method显示文摘 | Olhoft P M Flagel L E Donovan C M | | 0，，： | 1 |
| 12 | Engi neering disease resistant cattle显示文摘 | DONOVAN D M KERR D E WALL R J | 2005 | Transgenic Res2005，14，5： | 1 |
| 13 | Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae显示文摘 | Oldfield N J Donovan E A Worrall K E | 2008 | Vaccine2008，26，16： | 1 |
| 14 | Efficient soybean transformation using hyg~omycin B selection in the cotyledon- aft-node method 显示文摘 | Olhoft P M Flagel L E Donovan C M | 2003 | Planta2003，216，5： | 1 |
| 15 | Integrated approaches to managing weeds in spring-sown crops in western Canada显示文摘 | ODonovan J T Blackshaw R E Harker K N | 2007 | Crop Protection2007，26，3： | 1 |
| 16 | Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy 显示文摘 | Donovan E Bleakley N Denholm E | 2007 | Radiother Oncol2007，82，3： | 1 |
| 17 | A randomized trial comparing transurethral resection of the prostate, laser therapy and conservative largment:the claspstudy显示文摘 | Donovan J L Peters T J Neal D E | 2000 | J Urol2000，164，： | 1 |
| 18 | Water relationships and composition of wheat ears grown in liquid culture: effect of carbon and nitrogen显示文摘 | Barlow E W R Donovan G R Lee J W | 1983 | Australian Journal of Plant Physiology1983，10，： | 1 |
| 19 | Efficient soybean transformation using hygromycin B selection in the cotyledonary node method显示文摘 | OLHOFT P M FLAGEL L E DONOVAN C M | 2003 | Planta2003，5，： | 1 |
| 20 | Adaptability in the workplace : development of a taxonomy of adaptive performance 显示文摘 | Pulakos E D Arad S Donovan M A Plamondon K E | 2000 | Journal of Applied Psychology2000，85，4： | 1 |
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