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| 1 | Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?显示文摘BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to occur.Conventional coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left untreated.Thromboelastogram(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide anticoagulation.TEG is better than CCT because it is dynamic and provides a global hemostatic profile including fibrinolysis.AIM To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant recipients.METHODS A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG results.Graft loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were compared.RESULTS Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on CCT.No graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45.10%in the CCT group(P=0.05,Fisher’s exact test).The incidence of radiologically confirmed partial thrombus in pancreas allograft was 41.18%in the TEG and 25.50%in the CCT group(P=0.23,Fisher’s exact test).All recipients with partial thrombi detected in computed tomography(CT)scan had an anticoagulation dose escalation.The thrombus resolution rates in subsequent scan were 85.71%and 63.64%in the TEG group vs the CCT group(P=0.59,Fisher’s exact test).The TEG group had reduced blood product usage{10 packed red blood cell(PRBC)and 2 fresh frozen plasma(FFP)}compared to the CCT group(71 PRBC/10 FFP/2 cryoprecipitate and 2 platelets).The proportion of patients requiring transfusion in the TEG group was 17.65%vs 39.25%in the CCT group(P=0.14,Fisher’s exact test).The median length of hospital stay was 18 days in the TEG group vs 31 days in the CCT group(P=0.03,Mann Whitney test).The 1-year pancreas graft survival was 100%in the TEG group vs 82.35%in the CCT group(P=0.07,log rank test)and,the 1-year kidney graft survival was 100%in the TEG group vs 92.15%in the CCT group(P=0.23,log tank test).CONCLUSION TEG is a promising tool in guiding judicious use of anticoagulation with concomitant prevention of graft loss due to thrombosis,and reduces the length of hospital stay. | Jeevan Prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois Anand SR Muthusamy | 2020 | World Journal of Transplantation2020，10，7： | 2 |
| 2 | Synchronous electrogastrographic and manometric study of the stomach as an esophageal substitute显示文摘AIM: To investigate the electric and contractile mechanisms involved in the deranged function of the transposed stomach in relation to the course of the symptoms and the changes in contractile and electrical parameters over time.METHODS: Twenty-one patients after subtotal esophagectomy and 18 healthy volunteers were studied.Complaints were compiled by using a questionnaire, and a symptom score was formed. Synchronous electrogastrography and gastric manometry were performed in the fasting state and postprandially.RESULTS: Eight of the operated patients were symptomfree and 13 had symptoms. The durations of the postoperative periods for the symptomatic (9.1±6.5 mo)and the asymptomatic (28.3±8.8 mo) patients were significantly different. The symptom score correlated negatively with the time that had elapsed since the operation. The percentages of the dominant frequency in the normogastric, bradygastric and tachygastric ranges differed significantly between the controls and the patients.A significant difference was detected between the power ratio of the controls and that of the patients. The occurrence of tachygastria in the symptomatic and the symptom-free patients correlated negatively both with the time that had elapsed and with the symptom score. There was a significant increase in motility index after feeding in the controls, but not in the patients. The contractile activity of the stomach increased both in the controls and in the symptom-free patients. In contrast, in the group of symptomatic patients, the contractile activity decreased postprandially as compared with the fasting state.CONCLUSION: The patients' post-operative complaints and symptoms change during the post-operative period and correlate with the parameters of the myoelectric and contractile activities of the stomach. Tachygastria seems to be the major pathogenetic factor involved in the contractile dysfunction. | Ferenc Izbéki Tibor Wittmann Sándor (O|')dor Balázs Botos (A|')ron Altorjay | 2005 | World Journal of Gastroenterology2005，11，8： | 2 |
| 3 | Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing显示文摘 | Tae-Hoon Kim Sung-Hee Kim George K. Sádor Yong-Deok Kim | 2014 | Archives of Oral Biology2014，，： | 2 |
| 4 | Semicirfular canal fenestration- improvement of bone not air- conducted auditory thresholds显示文摘 | Sohmer H Freeman S Geal- Dor M | 2004 | Hear Res2004，187，： | 1 |
| 5 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 6 | Effect of phenolic acids in soil under and between rows of a prior sorghum (Sorghum bicolor) crop on germination,emergence,and seedling growth of peanut (Arachis hypogea)显示文摘 | SéNE M DORé T PELLISSIER F | 2000 | Journal of chemical ecology2000，26，3： | 1 |
| 7 | Inflammation after intracerebral hemorrhage显示文摘 | Wang J Doré S | 2007 | J Cereb Blood Flow Metab2007，，5： | 1 |
| 8 | Heme oxygenase-1 protects brain from acute excitotoxicity显示文摘 | Ahmad A Zhuang H Doré S | | 0，，04： | 1 |
| 9 | The effects of selenium against cerebral ischemia-reperfusion injury in rats显示文摘 | Ozbal S Erbil G Kodor H | 2008 | Neurosci Lett2008，438，3： | 1 |
| 10 | Core/CdS quantum dot/ shell mesoporous solar cells with improved stability and efficiency using an amorphous Ti02 coating显示文摘 | Shalom M Dor S Riihle S | 2009 | J Phys Chern C2009，113，9： | 1 |
| 11 | Effect of phenolic acids in soil under and between rows of a prior sorghum (Sorghum bicolor) crop on germination, emergence, and seedling growth of peanut (Arachishypogea) 显示文摘 | S NE M DOR T Pellisser F | 2000 | Journal of Chemical Ecology2000，26，3： | 1 |
| 12 | Core/CdS quantum dot/shell mesoporous solar cells with improved stability and efficiency suing an amorphous TiO2 coating 显示文摘 | SHALOM M DOR S RUHLE S | 2009 | J Phys Chem C2009，113，9： | 1 |
| 13 | Ultrastruc tural characterization of human granulosa cells in stimula- ted cycles:correlation with oocyte fertilizability显示文摘 | ROTMENSCH S DOR J FURMAN A | 1986 | Fertil Steril1986，45，5： | 1 |
| 14 | The role of early postimplantation beta-HCG levels in the outcome of pregnancies following in-vitro fertilization显示文摘 | Dor J Rudak E Rotmench S | 1988 | Hum Reprod1988，3，： | 1 |
| 15 | The welfare effects of mergers in the hospital industry显示文摘 | Calem Paul S Dor Avi Rizzo John A | 1999 | Journal of Economics and Business1999，51，3： | 1 |
| 16 | Inflammation after intracerebral hemorrhage显示文摘 | Wang J Doré S | 2007 | J Cereb Blood Flow Metab2007，27，： | 1 |
| 17 | The relationships between endometrial thickness, and blood flow and pregnancy rates in in-vitro fertilization 显示文摘 | Yuval Y Lipitz S Dor J | 1999 | Hu man Reproduction1999，14，4： | 1 |
| 18 | The welfare effects of mergers in the hospital industry显示文摘 | Calem P S Dor A Rizzo J A | 1999 | Journal of Economics and Business1999，51，3： | 1 |
| 19 | Importance of normothermia control in investigating delayed neuronal injury in a mouse global ischemia model显示文摘 | Wei G Doré S | 2010 | J Neurosci Methods2010，185，2： | 1 |
| 20 | Alpha1, 3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months 显示文摘 | Tseng Y L Dor F J Shimizu A Houser S Hisashi Y Yamada K Robson S C Awwad M Schuurman H J Sachs D H Cooper D K | 2005 | Transplantation2005，80，11： | 1 |
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