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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Effect of Initial pH on the Deflaking Rate of Recovered Papers显示文摘 | F Brouillette C Daneault G M Dorris | 2003 | Pulp and Paper Canada2003，104，7： | 1 |
| 3 | Effect of initial pH on the deflaking rate of recovered papers显示文摘 | Brouillette F Daneault C Dorris G M | 2003 | Pulp and Paper Canada2003，104，7： | 1 |
| 4 | Effect of Initial pH on the Release of Dissolved, Colloidal and Suspended Solids During Repulping of ONP and OMG显示文摘 | Brouillette F Da nealut C Dorris G M | 2002 | Journal of Pulp and Paper Science2002，28，2： | 1 |
| 5 | Thermogravimetric dermination of synthetic polymers in recycled pulp systems and deposits显示文摘 | Castro C Dorris G M Brouillette F el al | 2003 | J Pulp Paper Sci2003，29，5： | 1 |
| 6 | Thermogravimetric dermination of synthetic polymers in recycled pulp systems and deposits显示文摘 | Castro C Dorris G M Brouillette F | | 0，，05： | 1 |
| 7 | Effect of Initial pH on the Release of dissolved,Colloid and Suspended Solids During Repulping of ONP and OMG显示文摘 | Brouillette F Daneault C Dorris G M | 2002 | JPPS2002，28，2： | 1 |
| 8 | Effect of Initial pH on the release of dissolved, colloidal and suspended solids during repulping of ONP and OMG显示文摘 | Brouillette F Danealut C Dorris G M | 2002 | Journal of Pulp and Paper Science2002，28，2： | 1 |
| 9 | The architecture of theleft ventricular myocytes relative to left ventricular systolic fu n ctio n 显示文摘 | Dorri F Niederer PF Lunkenheimer PP | | Eur J Cardiothorac Surg0，37，2： | 1 |
| 10 | Effect of initial pH on the deflaking rate of recovered papers显示文摘 | Brouillette F Daneault C Dorris G M | 2003 | Pulp and Paper Canada2003，104，7： | 1 |
| 11 | An analysis of the spatial arrangement of the myocardial aggregates making up the wall of the lett ventricle显示文摘 | Dorri F Niederer PF Redmann K | 2007 | Eur J Cardiothorac Surg2007，31，3： | 1 |
| 12 | Effect of initial pH on the release of dissolved,colloidal and suspended solids during repulping of ONP and OMG显示文摘 | Brouillette F Dorris G and Daneault C | 2002 | JPPS2002，28，2： | 1 |
| 13 | Clinical course and treatment of haemorrhagic cystitis associated with BK type of human polyomavirus in nine paediatric recipients of allogeneic bone marrow transplants 显示文摘 | Peinemann F de Villiers EM Dorries K | 2008 | Eur J Pediatr2008，159，3： | 1 |
| 14 | Effect of Initial pH on the Release of dissolved, Colloid and Suspended Solids During Repulping of ONP and OMG显示文摘 | Brouillette F Daneault C Dorris G M | 2002 | JPPS2002，28，2： | 1 |
| 15 | Comparison be- tween three supportive treatments for prevention of con- trast-induced nephropathy in high-risk patients undergoing coronary angiography 显示文摘 | Yeganehkhah MR Iranirad L Dorri F | 2014 | Kidney Dis Transpl2014，25，6： | 1 |
| 16 | Effect of initial pH on the deflaking rate of recovered papers显示文摘 | F Brouillette C Daneault G M Dorris | 2003 | Pulp and Paper Canada2003，104，7： | 1 |
| 17 | Expression of correctly processed human growth hormone in seeds of transgenic tobacco plants 显示文摘 | Leite A Kemper E L Da Silva M J Luchessi A D Siloto R M P Bonaccorsi E D E1 - Dorry H F Arruda P | 2000 | Mol Breed2000，6，： | 1 |
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