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| 1 | Vasoactive intestinal peptide signaling axis in human leukemia显示文摘The vasoactive intestinal peptide (VIP) signaling axis constitutes a master 'communication coordinator' between cells of the nervous and immune systems.To date,VIP and its two main receptors expressed in T lymphocytes,vasoactive intestinal peptide receptor (VPAC)1 and VPAC2,mediate critical cellular functions regulating adaptive immunity,including arresting CD4 T cells in G 1 of the cell cycle,protection from apoptosis and a potent chemotactic recruiter of T cells to the mucosa associated lymphoid compartment of the gastrointestinal tissues.Since the discovery of VIP in 1970,followed by the cloning of VPAC1 and VPAC2 in the early 1990s,this signaling axis has been associated with common human cancers,including leukemia.This review highlights the present day knowledge of the VIP ligand and its receptor expression profile in T cell leukemia and cell lines.Also,there will be a discussion describing how the anti-leukemic DNA binding transcription factor,Ikaros,regulates VIP receptor expression in primary human CD4 T lymphocytes and T cell lymphoblastic cell lines (e.g.Hut-78).Lastly,future goals will be mentioned that are expected to uncover the role of how the VIP signaling axis contributes to human leukemogenesis,and to establish whether the VIP receptor signature expressed by leukemic blasts can provide therapeutic and/or diagnostic information. | Glenn Paul Dorsam Keith Benton Jarrett Failing Sandeep Batra | 2011 | World Journal of Biological Chemistry2011，2，6： | 4 |
| 2 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 3 | Inactivation of the human P2Y12 receptor by thiol reagents requires intcractionwith both extraccllular cysteine residues, Cysl7 and Cys270显示文摘 | Ding Z KimS Dorsam R | 2003 | Blood2003，101，： | 1 |
| 4 | Src family kinase- mediated and Erk - mediated thromboxane A2 generation are essential for VWF/GP Ⅰ b - induced fibrinogen receptor activation in human platelets显示文摘 | GARCIA A QUINTON T M DORSAM R T | 2005 | Blood2005，6，： | 1 |
| 5 | Transduction of multiple effects of sphingusine 1 -phosphate (S 1 P) on T cell fimctions by the S 1P 1 G protein-coupled receptor显示文摘 | Dorsam G Graeler MH Seroogy C | 2003 | J lmmunol2003，171，7： | 1 |
| 6 | Surgical technique for totally implantable access ports (TIAP) needs improvement: a multivariate analysis of 400 patients 显示文摘 | Seiler CM Frohlich BE Dorsam U J | 2006 | Surg Oncol2006，93，1： | 1 |
| 7 | Transduction of multiple effects of sphingosine 1-phosphate(S1P)on T cell functions by the S1P1 G protein-coupled receptor显示文摘 | Dorsam G Graeler M H Seroogy C | 2003 | J Immunol2003，171，7： | 1 |
| 8 | Central role of the P2Y12 receptor in platelet activa- tion显示文摘 | Dorsam RT Kunapuli SP | 2004 | J Clin Invest2004，113，3： | 1 |
| 9 | c-Maf and JunB Mediation of Th2 Differentiation Induced by the Type 2 G Protein-Coupled Receptor (VPAC2) for vasoactive Intestinal peptide显示文摘 | Voice J Donnelly S Dorsam G | 2004 | J Immunol2004，172，12： | 1 |
| 10 | The Crystal Structure of 8-Na2Si2O5 显示文摘 | Kahlenberg V Dorsam G Wendschuh-Josties M | 1999 | Journal of Solid State Chemistry1999，146，2： | 1 |
| 11 | C-protein-coupled receptors and cancer 显示文摘 | Dorsam RT Gutkind JS | 2007 | Nat Rev Cancer2007，7，2： | 1 |
| 12 | G-protein-coupled receptors andcancer显示文摘 | Dorsam RT Gutkind JS | 2007 | Nat Rev Cancer2007，7，： | 1 |
| 13 | Central role of the P2Y12 receptor in platelet activation 显示文摘 | Dorsam RT Kunapuli SP | 2004 | J Clin Invest2004，113，3： | 1 |
| 14 | Central role of the P2Y12 receptor in platelet activation, 显示文摘 | Dorsam RT Kunapuli SP | 2004 | Clin Invest2004，113，3： | 1 |
| 15 | G-protein-coupled receptors and cancer显示文摘 | Dorsam R Gutkind J | 2007 | Nat Rev Cancer2007，7，2： | 1 |
| 16 | C-Maf and JunB medliation of Th2 differentiayion induced by the type 2 G Protein-Coupled Receptor(VPAC2) for vasoaction intes-tinal peptide显示文摘 | Voice J Donnelly S Dorsam G | | 0，，12： | 1 |
| 17 | The crystal structure of δ-Na2Si2O5 显示文摘 | Kahtenberg V Dorsam G Wendschuh-Josties M | 1999 | Journal of Solid State Chemistry1999，146，2： | 1 |
| 18 | Inactivation of the human P2Y12receptor by thiol reagents requires interaction with both extracellular cysteine residues Cysl 7 and Cys 270显示文摘 | Ding Z Kim S Dorsam RT | 2003 | Blood2003，101，： | 1 |
| 19 | Central role of the P2Y12 re- ceptor in platelet activation 显示文摘 | Dorsam RT Kunapuli SP | 2004 | Clin Invest2004，113，： | 1 |
| 20 | The Crystal Structure of δ - Na2 Si2O5 显示文摘 | Kahlenberg V Dorsam G Wendschuh - Josties M | 1999 | Journal of Solid State Chemistry1999，146，： | 1 |
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