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| 1 | Long term effect of low intensity pulsed ultrasound on a human tooth slice organ culture显示文摘 | A1-Daghreer S Doschak M Sloan AJ | 2012 | Arch Oral Biol2012，57，6： | 1 |
| 2 | Poly- ethylenimine-PEG coated albumin nanoparticles for BMP-2 de- livery显示文摘 | ZHANG S KUCHARSKI C DOSCHAK M R | 2010 | Biomaterials2010，31，5： | 1 |
| 3 | Short- term effect of low-intensity pulsed ultrasound on an ex-vivo 3-d tooth culture显示文摘 | A1-Daghreer S Doschak M Sloan AJ | 2013 | Ultrasound Med Biol2013，39，6： | 1 |
| 4 | Osteogenic re- sponse of bone marrow stromal cells from normal and ovariec- tomized rats treated with a low dose of basic fibroblast growth factor 显示文摘 | Varkey M Kucharski C Doschak MR | 2007 | TissueEng2007，13，： | 1 |
| 5 | Effect of Low-Intensity Pulsed Ultrasound on Orthodontically Induced Root Resorption in Beagle Dogs 显示文摘 | A1-Daghreer S Doschak M Sloan A J | 2014 | Ultrasound Med Biol2014，40，6： | 1 |
| 6 | Osteogenic response of bone marrow stromal cells from normal and ovariectomized rats treated with a low dose of basic fibroblast growth factor显示文摘 | Varkey M Kucharski C Doschak MR | 2007 | Tissue Eng2007，13，4： | 1 |
| 7 | Polyethylenimine- PEG coated albumin nanoparticles for BMP-2 delivery显示文摘 | Zhang Su-feng Kucharski C Doschak MR | 2010 | Biomate- rials2010，31，5： | 1 |
| 8 | Anabolic effects of low-intensity pulsed ultrasound on human gingival fibroblasts显示文摘 | Nesrine Z. Mostafa Hasan Uluda? Douglas N. Dederich Michael R. Doschak Tarek H. El-Bialy | 2009 | Archives of Oral Biology2009，，8： | 1 |
| 9 | Osteogenic response of bone marrow stromal cells from normal and ovariec- tomized rats treated with a low dose of basic fibroblast growth factor显示文摘 | Varkey M Kucharski C Doschak M R Winn S R Brochmann E J Murray S | 2007 | Tissue Eng2007，13，： | 1 |
| 10 | Osteo- genic response of hone marrow stromal cells from normal and ovariectomized rats treated with a low dose of basic fibroblast growth factor显示文摘 | VARKEY M KUCHARSKI C DOSCHAK M R | 2007 | Tissue Eng2007，13，4： | 1 |
| 11 | Effect of LIPUS on orthodontically induced root resorption in Beagle dogs显示文摘 | Saleh Al-Daghreer Michael Doschak Alastair J. Sloan Paul W. Major Giseon Heo Cristian Scurtescu Ying Y. Tsui Tarek El-Bialy | 2013 | Ultrasound in Medicine & Biology2013，，： | 1 |
| 12 | Are the release characteristics of Erzhi pills in line with traditional Chinese medicine theory?A quantitative study显示文摘Objective:Traditional Chinese medicine(TCM)has been widely used throughout China to prevent and cure diseases for thousands of years,and now it is a part of the integrative medicine field that is available in Western societies.To ensure the safety and quality of the herbal medicines that are a major part of the TCM tradition,they must be held to modern pharmaceutical standards.Erzhi pill(EZP)is a Chinese Pharmacopeia-listed herbal preparation that is used in the long-term clinical management of postmenopausal symptoms,osteoporosis and menstrual disorders.Until now,whether the drug release mechanism of EZP is in line with its intended TCM usage has not been studied.Methods:The release of specnuezhenide from three EZPs(self-made,Leiyunshang and Renhe)in simulated gastric fluid(SGF),acetate buffer(p H 4.5 buffer)and simulated intestinal fluid(SIF)was investigated in a dissolution test.The water uptake capacity and erosion extent of the three EZPs were investigated using swelling and erosion studies.The drug release mechanism was further assessed through statistical model fitting,using DDSolver software.Results:The release of specnuezhenide from all three EZPs in SGF was less than 50%within a 4 h period.However,over 70%of the specnuezhenide was released from each EZP in both p H 4.5 buffer and SIF in the same time.Analysis of the swelling and erosion behaviors and the drug release mechanism of the three EZPs confirmed that the release rate from EZP followed a sustained release profile,which was an interactive combination of swelling and erosion.Conclusion:This study showed that the release pattern from the pills was in line with the intended TCM use of EZP.TCM had not only theoretically considered sustained release from the pills,but also formulated them to achieve this release pattern.When establishing quality control standards for pills,the theoretical TCM usage and the actual release patterns need to be considered. | Jie-yu Zuo Chulhun Park Michael Doschak Raimar Lobenberg | 2021 | Journal of Integrative Medicine2021，19，1： | 0 |
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