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| 1 | Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study显示文摘AIM To determine the incidence of hepatocellular carcinoma(HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients(16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10 th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients(P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less(P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54(0.15-1.89), P = 0.33].CONCLUSION HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis. | Marcelo Campos Appel-da-Silva Suelen Aparecida da Silva Miozzo Isabella de Azevedo Dossin Cristiane Valle Tovo Fernanda Branco Angelo Alves de Mattos | 2016 | World Journal of Gastroenterology2016，22，46： | 7 |
| 2 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 3 | Simulation of heterogeneously MgO-catalyzed transesterification for fine-chemical and biodiesel industrial production显示文摘 | DOSSIN T F REYNIERS M F BERGER R J | 2006 | Applied Catalysis B:Environmental2006，67，12： | 1 |
| 4 | Simulation of heterogeneously MgO-catalyzed transesterification for fine-chemical and biodiesel industrial production显示文摘 | Dossin T F Reyniers M F Berger R J | 2006 | Appl Catal B2006，67，12： | 1 |
| 5 | Laboratory tests for diagnosis of gastrointestinal and pancreatic diseases显示文摘 | Dossin O | 2011 | Top Companion Anita Med2011，26，2： | 1 |
| 6 | Determination of the artificial sweetener Sucra-lose by capillary electrophoresis显示文摘 | Stroka J DossiN Anklam E | 2003 | Food Addit Contam2003，20，6： | 1 |
| 7 | Laboratory tests for diagnosis of gastrointesti- nal and pancreatic diseases显示文摘 | Dossin O | 2011 | Top Comp Anita Med2011，26，2： | 1 |
| 8 | Kinetics of heterogeneously MgO-catalyzed transesterification显示文摘 | Dossin T F Reyniers M F Matin G B | 2006 | Applied Catalysis B:Environmental2006，61，12： | 1 |
| 9 | Simula- tion of heterogeneously MgO-catalyzed transesterification for fine-chemical and biodiesel industrial production 显示文摘 | Dossin T F Reyniers M F Berger R J | 2006 | Applied Catalysis B: Environmental2006，67，12： | 1 |
| 10 | Comparative field evaluation of marbofloxaein tablets in the treatment of feline upper respiratory infextions显示文摘 | Dossin O Gruet P Thomas E | 1998 | J Small Anita Pract1998，39，6： | 1 |
| 11 | Simulation of heterogeneously MgO-catalyzed transesterificationfor fine-chemical and biodiesel industrial production显示文摘 | Dossin T F Reyniers M F Berger R J Marin G B | 2006 | Applied Catalysis B:Environmental2006，67，12： | 1 |
| 12 | Kinetics of heterogeneously MgO-catalyzed transesterification显示文摘 | Dossin TF Reyniers MF Marin GB | 2006 | Appl Catal B2006，61，： | 1 |
| 13 | Kinetics of heterogeneously MgO-catalyzed transesterification显示文摘 | Dossin Tanguy F | 2006 | Applied Catalysis B Environmental2006，62，12： | 1 |
| 14 | Laboratory tests for diagnosis of gastrointestinal and pancreatic diseases显示文摘 | Dossin O | 2011 | Top Companion Anim Med2011，26，2： | 1 |
| 15 | Comparative field evaluation of marbofloxacin tablets in the treatment of feline upper respiratory infections显示文摘 | Dossin O Gruet P Thomas E | 1998 | Journal of Small Animal Practice1998，39，6： | 1 |
| 16 | 皮革等时尚奢侈品制作酝酿走出意大利显示文摘在米兰举行的2006年春夏时装发布会期间,各大奢侈品公司以及其他行业的一些参与者围绕着“把部分奢侈品的生产转移到中国、印度或者东欧国家的可能性”展开了激烈讨论。我们预计,越来越多的奢侈品牌开始把部分的生产外包到意大利以外的国家,而一些高级品牌也像其附牌一样,正在寻求走出“意大利制作”的途径。这似乎成了这些品牌在应对来自Zara和H&M等时尚品牌的激烈竞争时,不得不考虑的一个问题。 | Jacques-Franck Dossin Luca Cipiccia 周莹(译) | 2006 | 北京皮革(中外皮革信息版)(中)2006，，3： | 0 |
| 17 | 奢侈品制造走出意大利显示文摘在米兰举行的2006年春夏时装发布会期间,各大奢侈品公司以及其他行业的一些参与者围绕着“把部分奢侈品的生科转移到中国,印度或者东欧国家的可能性”展开了激烈讨论。我们预计,越来越多的奢侈品牌开始把部分的生产外包到意大利以外的国家,而一些高级品牌也像其附牌一样。 | Jacques-Franck Dossin Luca Cipiccia 周莹(译) | 2006 | 新财富2006，，2： | 0 |
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