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| 1 | Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic(+3 oxidation state)methyltransferase-knockout mice显示文摘Arsenic methyltransferase(As3mt) catalyzes the conversion of inorganic arsenic(i As) to its methylated metabolites, including toxic methylarsonite(MAs~Ⅲ) and dimethylarsinite(DMAs~Ⅲ). Knockout(KO) of As3 mt was shown to reduce the capacity to methylate i As in mice. However, no data are available on the oxidation states of As species in tissues of these mice. Here, we compare the oxidation states of As species in tissues of male C57BL/6 As3mt-KO and wild-type(WT) mice exposed to arsenite(iA s~Ⅲ) in drinking water. WT mice were exposed to50 mg/L As and As3mt-KO mice that cannot tolerate 50 mg/L As were exposed to 0, 15, 20, 25 or30 mg/L As. iA s~Ⅲaccounted for 53% to 74% of total As in liver, pancreas, adipose, lung, heart, and kidney of As3mt-KO mice; tri- and pentavalent methylated arsenicals did not exceed 10% of total As. Tissues of WT mice retained iA s and methylated arsenicals: iA s~Ⅲ, MAs~Ⅲand DMAs~Ⅲ represented 55%‐68% of the total As in the liver, pancreas, and brain. High levels of methylated species, particularly MAs~Ⅲ, were found in the intestine of WT, but not As3mt-KO mice,suggesting that intestinal bacteria are not a major source of methylated As. Blood of WT mice contained significantly higher levels of As than blood of As3mt-KO mice. This study is the first to determine oxidation states of As species in tissues of As3mt-KO mice. Results will help to design studies using WT and As3mt-KO mice to examine the role of iA s methylation in adverse effects of iA s exposure. | Jenna M.Currier Christelle Douillet Zuzana Drobná Miroslav Styblo | 2016 | Journal of Environmental Sciences2016，28，11： | 8 |
| 2 | Optical algorithms at satellite wavelengths for Total Suspended Matter in tropical coastal waters显示文摘 | Ouillon S Douillet P Petrenko A | 2008 | Sensors2008，8，7： | 1 |
| 3 | Nanoencap- sulation of Curcumin in Polyurethane and Polyurea Shells by An Emulsion Diffusion Method 显示文摘 | SOUGUIR H SALAUN F DOUILLET P | 2013 | Chemical Engineering Journal2013，221，： | 1 |
| 4 | Bacterial additives that consistently enhance rorifer growth rnder growth under synxenic culture conditions显示文摘 | Douillet P A | 2000 | Aqua- culture2000，182，： | 1 |
| 5 | Effect of ventilatory rate on airway cytokine levels and lung injury显示文摘 | Rich PB Douillet CD Hurd H | 2003 | J Surg Res2003，113，1： | 1 |
| 6 | Effect of ventilatory rate on airway cytokine levels and lung injury显示文摘 | RICH P B DOUILLET C D HURD H | 2003 | J Surg Res2003，113，1： | 1 |
| 7 | A selenium supplement associated or not with vitamin E delays early renal lesions in experimental diabetes in rats显示文摘 | Douillet C Tabib A Bost M | 1996 | J Proc Soc Exp Biol Med1996，211，： | 1 |
| 8 | Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy显示文摘 | Beidler SK Douillet CD Berndt DF | 2009 | J Vasc Surg2009，49，4： | 1 |
| 9 | 查看详情显示文摘 | Reitze D H Kazamias S Weihe F Mullot G Douillet D Augé F Albert O Ramanathan V Chambaret J P Hulin D Balcou P | | 0，，： | 1 |
| 10 | Physicochemical properties of a novel series of amphiphilic sugar-based molecules: 1-O-n-alkyl-D, L- xylitols 显示文摘 | Van Roekeghem P Savelli-Boukhaled M P Douillet O | 1997 | S T P Pharma Sciences1997，7，5： | 1 |
| 11 | Use of a probiotic for the culture of larvae of the Pacific oyster(Crassostrea gigas Thunberg)显示文摘 | Douillet P A Langdon C J | 1994 | Aquaculture1994，119，： | 1 |
| 12 | Bacterial additives that consistently enhance rotifer growth under synxenic culture conditions - use of single and multiple bacterial probiotics 显示文摘 | Douillet P A | 2000 | Aqua2000，182，： | 1 |
| 13 | Distinguishing between physiologic hypertrophy in athletes and primary hypertrophic cardiomyopathies:importance of tissue color Doppler显示文摘 | Douillet R Troniou A | 1999 | Arch Mal Coeur Vaiss1999，92，2： | 1 |
| 14 | Effect of ventilatory rate on airway cytokine levels and lung injury显示文摘 | Rich PB Douillet CD Hurd H | 2003 | J Surg Res2003，113，1： | 1 |
| 15 | Multiplexed analysis of matrix metalloproteinases in leg ulcer tissue of patients with chronic venous insufficiency before and after compression therapy 显示文摘 | Bcidler S K Douillet C D Berndt D F | 2008 | Wound Repair Regcn2008，16，5： | 1 |
| 16 | Use of a probiotic for the culture of larvae of the Pacific oyster (Crassostrea gigas Thunberg )显示文摘 | DOUILLET P A LANGDON C J | 1994 | Aquaculture1994，119，： | 1 |
| 17 | Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells:role of TGF-beta and MAPK 显示文摘 | Douillet CD Velarde V Christopher JT | 2000 | Am J Physiol Heart Circ Physiol2000，279，： | 1 |
| 18 | 查看详情显示文摘 | DOUILLET P A Langdon C J | | 0，，： | 1 |
| 19 | Nucleotides induce IL-6 release from human airway epithelia via P2Y2 and p38 MAPKdependent pathways显示文摘 | Douillet CD Robinson WP Milano PM | 2006 | Am J Physiol Lung Cell Mol Physiol2006，291，： | 1 |
| 20 | Coupling satellite data with in situ measurements and numerical modeling to study fine suspended-sediment transport: a study for the lagoon of New Caledonia显示文摘 | Ouillon S Douillet P Andrefouet S | 2004 | Coral Reefs2004，23，： | 1 |
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