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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Slope stability analysis by strength reduction显示文摘 | DAWSON E M ROTHW H DRESCHER A | 1999 | Geotechnique1999，49，6： | 1 |
| 3 | Slope stability analysis by strength reduction显示文摘 | DAWSON E M ROTH W H DRESCHER A | 1999 | Geotechnique1999，49，6： | 1 |
| 4 | Interaction of two actinbinding proteins, synaptopodin and alpha -actinin -4, with the tight junction protein MAGI -l显示文摘 | PATR/E K M DRESCHER A J WELIHINDA A | 2002 | J Biol Chem2002，277，30： | 1 |
| 5 | Stiffness es- timates using portable deflectometers 显示文摘 | Hoffmann O J M Guzina B B Drescher A | 2004 | Transporta- tion Research Record2004，，1869： | 1 |
| 6 | Is helical blade nail-ing superior to locked minimally invasive plating in unstablepertrochanteric fractures显示文摘 | Knobe M Drescher W Heussen N | 2012 | Clin Orthop Relat Res2012，47，28： | 1 |
| 7 | The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells显示文摘 | Drescher S van der Kuip H | 2001 | Pharmacogenetics2001，11，： | 1 |
| 8 | Differential expression of vascular endothelial growth factor in glucocorticoid - related osteonecrosis of the femoral head显示文摘 | Varoga D Drescher W Pule M | 2009 | C/in Orthop Re/at Res2009，467，12： | 1 |
| 9 | Slope stability anal- ysis by strength reduction 显示文摘 | Dawson E M Roth W H Drescher A | 1999 | Geoteclmique1999，49，3： | 1 |
| 10 | Is helical blade nailing superior to locked minimally invasive plating in un- stable pertrochanteric fractures 显示文摘 | Knobe M Drescher W Heussen N | 2012 | Clin Orthop Relat Res2012，470，8： | 1 |
| 11 | Slope stability analysis by strength reduction 显示文摘 | Dawson E M Roth W H Drescher A | 1999 | Geotechnique1999，49，6： | 1 |
| 12 | X-ray Pulses Approaching the Attosecond Frontier显示文摘 | Drescher M Hentschel M Kienberger R | 2001 | Science2001，291，： | 1 |
| 13 | Slope stability analysis by strength reduction显示文摘 | Dawson E M Roth W H Drescher A | 1999 | Geotechnique1999，49，6： | 1 |
| 14 | Cryptosporidium inactivation by low-pressure UV in a water显示文摘 | Drescher A C Greene D M Gadgil A J 2001 | 2001 | J Environ Health2001，64，3： | 1 |
| 15 | Slope stability analysis by strength reduction显示文摘 | DAWSON E M ROTH W H DRESCHER A | 1999 | Geotechnique1999，49，6： | 1 |
| 16 | Slope Stability Analysis by Strength Reduction显示文摘 | Dawson E M Roth W H Drescher A | 1999 | Geotechnique1999，49，6： | 1 |
| 17 | Evaluation of ovarian cancer remission markers HE4, MMP7 and Me- sothelin by comparison to the established marker CA125 显示文摘 | Schummer M Drescher C Forrest R | 2012 | Gynecol Oncol2012，125，1： | 1 |
| 18 | Slope stability analysis by strength reduction 显示文摘 | Dawson E M Roth W H Drescher A | 1999 | Geotechnique1999，49，6： | 1 |
| 19 | Slope stability analysis by strength reduction显示文摘 | Dawson E M Roth W H Drescher A | 1999 | Geotechnique1999，49，6： | 1 |
| 20 | Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer:Evidence supporting a mesothelial-toepithelial transition显示文摘 | Bendoraite A Knouf E C Garg K S Parkin R K Kroh E M O'Briant K C Ventura A P Godwin A K Karlan B Y Drescher C W and others | | 0，，01： | 1 |
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