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| 1 | Cyclophilina Specific Cytosolic Binding Protein for Cyclosporin A 显示文摘 | HANDSCHUMACHER R E HARDING M W DRUGGE R J | 1984 | Science1984，226，： | 1 |
| 2 | Effectiveness, safety, and drug sustainability of biologics in elderly patients with inflammatory bowel disease: A retrospective study显示文摘BACKGROUND Biologic therapy resulted in a significant positive impact on the management of inflammatory bowel disease(IBD) however data on the efficacy and side effects of these therapies in the elderly is scant.AIM To evaluate retrospectively the drug sustainability, effectiveness, and safety of the biologic therapies in the elderly IBD population.METHODS Consecutive elderly(≥ 60 years old) IBD patients, treated with biologics [infliximab(IFX), adalimumab(ADAL), vedolizumab(VDZ), ustekinumab(UST)] followed at the McGill University Inflammatory Bowel Diseases Center were included between January 2000 and 2020.Efficacy was measured by clinical scores at 3, 6-9 and 12-18 mo after initiation of the biologic therapy. Patients completing induction therapy were included. Adverse events(AEs) or serious AE were collected during and within three months of stopping of the biologic therapy.RESULTS We identified a total of 147 elderly patients with IBD treated with biologicals during the study period, including 109 with Crohn’s disease and 38 with ulcerative colitis. Patients received the following biologicals: IFX(28.5%), ADAL(38.7%), VDZ(15.6%), UST(17%). The mean duration of biologic treatment was 157.5(SD = 148) wk. Parallel steroid therapy was given in 34% at baseline,19% at 3 mo, 16.3% at 6-9 mo and 6.5% at 12-18 mo. The remission rates at 3, 6-9 and 12-18 mo were not significantly different among biological therapies. Kaplan-Meyer analysis did not show statistical difference for drug sustainability(P = 0.195), time to adverse event(P = 0.158) or infection rates(P = 0.973) between the four biologics studied. The most common AEs that led to drug discontinuation were loss of response, infusion/injection reaction and infection.CONCLUSION Current biologics were not different regarding drug sustainability, effectiveness, and safety in the elderly IBD population. Therefore, we are not able to suggest a preferred sequencing order among biologicals. | Gustavo Drugg Hahn Jean-Frederic LeBlanc Petra Anna Golovics Panu Wetwittayakhlang Abdulrahman Qatomah Anna Wang Levon Boodaghians Jeremy Liu Chen Kiow Maryam Al Ali Gary Wild Waqqas Afif Alain Bitton Peter Laszlo Lakatos Talat Bessissow | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 3 | Study of Critical Sections in Catenary Systems during Multiple Pantograph Operation显示文摘 | HARELL P DRUGGE L REIJM M | 2005 | Proceedings of the Institution of Mechanical Engineers Part F:Journal of Rail and Rapid Transit2005，219，4： | 1 |
| 4 | A Method to Find Correla- tions Between Steering Feel and Vehicle Handling Properties Using a Moving Base Driving Simulator 显示文摘 | Rothhamelm L M Ijkema J Drugge L | 2011 | Vehicle System Dynamics2011，49，12： | 1 |
| 5 | Multiple Pantograph Operation effects of Section Overlaps 显示文摘 | Harell Pia Drugge Lars Reijm Marten | 2004 | Vehicle System Dynamics2004，41，： | 1 |
| 6 | Wearable systems in nursing home care : prototyping experience 显示文摘 | Drugge M Hallberg J Parnes P | 2006 | Pervasive Computing IEEE2006，5，1： | 1 |
| 7 | Study of Critical Sections in Catenary Systems during Multiple Pantograph Operation 显示文摘 | HARELL P DRUGGE L REUM M | 2005 | Proceedings of the Institution of Mechanical Engineers2005，219，4： | 1 |
| 8 | Familial amyloidotic polyneuropathy in Sweden:geographical distribution,age of onset,and prevalence显示文摘 | Sousa A Andersson R Drugge U | 1993 | Hum Hered1993，43，5： | 1 |
| 9 | Familial amyloidotic polyneuropathy in Sweden a pedigree analysis显示文摘 | Drugge U Andersson R Chizari F | 1993 | J Med Genet1993，30，： | 1 |
| 10 | Clinical pathway for melanoma detection using comprehensive cutaneous analysis with Melanoscan? 显示文摘 | Drugge RJ Nguyen C Gliga L | 2010 | Dermatology Online Journal2010，16，8： | 1 |
| 11 | Familial amyloidotic polyneuropathy in Sweden:geographical distribution,age of onset,and prevalence显示文摘 | Sousa A Andersson R Drugge U | 1993 | Hum Hered1993，43，5： | 1 |
| 12 | Some eocene and oligocene phytoplankton from the Gulf Coast,USA显示文摘 | Drugg WS Loeblich Ar.Jr | | 0，，： | 1 |
| 13 | Effects of synthetic parathyroid hormone on hemodynamics and regional blood flows显示文摘 | Wang HH Drugge ED Yen YC Blumenthal MR Pang PK | | 0，，： | 1 |
| 14 | Familial amyloidotic polyneuropathy in Sweden : geographical distribution, age of onset, and prevalence显示文摘 | Sousa A Andersson R Drugge U | 1993 | Hum Sered1993，43，5： | 1 |
| 15 | Ride comfort simulation of a wheel loader with suspended axles显示文摘 | DRUGGE L | 2008 | International Journal of Vehicle Systems Modeling and Testing2008，3，3： | 1 |
| 16 | 将危险降到最低——新电容器能满足无功功率补偿的新需求显示文摘没有电容器,要进行无功功率补偿和滤波几乎是不可能的。常规的高压交流(HVAC)电容器都需要用油,因,此会造成漏油并存在发生火灾的危险,以及造成环境污染。ABB着手研制的新一代电容器可解决上述问题,是一种不用油的电容器。 | Birger Drugge Henning Fuhrmann Sari Laihonen Johan Mood | 2009 | 流程工业2009，，23： | 0 |
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